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Body mass index, waist circumference, and waist-hip ratio on the risk of total and type-specific stroke.
Arch Intern Med. 2007 Jul 09; 167(13):1420-7.AI

Abstract

BACKGROUND

Adiposity is an established risk factor for cardiovascular disease, but the relationship of adiposity with the risk of cerebrovascular disease is still to some extent unclear.

METHODS

We prospectively investigated the association of different indicators of adiposity (body mass index [BMI] [calculated as weight in kilograms divided by height in meters squared], waist circumference, and waist-hip ratio) with total and type-specific stroke incidence among 49 996 Finnish participants who were aged 25 to 74 years and free of coronary heart disease and stroke at baseline.

RESULTS

During a 19.5-year follow-up, 3228 people developed an incident stroke event (674 hemorrhagic and 2554 ischemic). Compared with normal-weight men (BMI, 18.5-24.9), the multivariate-adjusted (age, study year, smoking, physical activity, educational level, family history of stroke, and alcohol drinking) hazard ratios among lean (BMI, < 18.5), overweight (BMI, 25.0-29.9), and obese (BMI, > or = 30.0) men were 0.74 (95% confidence interval [CI], 0.18-2.96), 1.23 (95% CI, 1.10-1.37), and 1.59 (95% CI, 1.37-1.83) for total stroke, and 0.49 (95% CI, 0.07-3.50), 1.27 (95% CI, 1.12-1.44), and 1.70 (95% CI, 1.45-2.00) for ischemic stroke, respectively. Among women, the corresponding hazard ratios were 1.87 (95% CI, 1.12-3.14), 1.08 (95% CI, 0.95-1.22), and 1.30 (95% CI, 1.14-1.50) for total stroke, and 1.81 (95% CI, 0.97-3.41), 1.11 (95% CI, 0.96-1.28), and 1.41 (95% CI, 1.21-1.64) for ischemic stroke. Abdominal adiposity, defined as the highest quartile of waist circumference or waist-hip ratio, was associated with a greater risk of total and ischemic stroke in men but not in women.

CONCLUSIONS

Body mass index was a risk factor for total and ischemic stroke in men and women. Abdominal adiposity was a risk factor for total and ischemic stroke only in men.

Authors+Show Affiliations

Department of Health Promotion and Chronic Diseases Prevention, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland. hu.gang@ktl.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17620537

Citation

Hu, Gang, et al. "Body Mass Index, Waist Circumference, and Waist-hip Ratio On the Risk of Total and Type-specific Stroke." Archives of Internal Medicine, vol. 167, no. 13, 2007, pp. 1420-7.
Hu G, Tuomilehto J, Silventoinen K, et al. Body mass index, waist circumference, and waist-hip ratio on the risk of total and type-specific stroke. Arch Intern Med. 2007;167(13):1420-7.
Hu, G., Tuomilehto, J., Silventoinen, K., Sarti, C., Männistö, S., & Jousilahti, P. (2007). Body mass index, waist circumference, and waist-hip ratio on the risk of total and type-specific stroke. Archives of Internal Medicine, 167(13), 1420-7.
Hu G, et al. Body Mass Index, Waist Circumference, and Waist-hip Ratio On the Risk of Total and Type-specific Stroke. Arch Intern Med. 2007 Jul 9;167(13):1420-7. PubMed PMID: 17620537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body mass index, waist circumference, and waist-hip ratio on the risk of total and type-specific stroke. AU - Hu,Gang, AU - Tuomilehto,Jaakko, AU - Silventoinen,Karri, AU - Sarti,Cinzia, AU - Männistö,Satu, AU - Jousilahti,Pekka, PY - 2007/7/11/pubmed PY - 2007/8/19/medline PY - 2007/7/11/entrez SP - 1420 EP - 7 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 167 IS - 13 N2 - BACKGROUND: Adiposity is an established risk factor for cardiovascular disease, but the relationship of adiposity with the risk of cerebrovascular disease is still to some extent unclear. METHODS: We prospectively investigated the association of different indicators of adiposity (body mass index [BMI] [calculated as weight in kilograms divided by height in meters squared], waist circumference, and waist-hip ratio) with total and type-specific stroke incidence among 49 996 Finnish participants who were aged 25 to 74 years and free of coronary heart disease and stroke at baseline. RESULTS: During a 19.5-year follow-up, 3228 people developed an incident stroke event (674 hemorrhagic and 2554 ischemic). Compared with normal-weight men (BMI, 18.5-24.9), the multivariate-adjusted (age, study year, smoking, physical activity, educational level, family history of stroke, and alcohol drinking) hazard ratios among lean (BMI, < 18.5), overweight (BMI, 25.0-29.9), and obese (BMI, > or = 30.0) men were 0.74 (95% confidence interval [CI], 0.18-2.96), 1.23 (95% CI, 1.10-1.37), and 1.59 (95% CI, 1.37-1.83) for total stroke, and 0.49 (95% CI, 0.07-3.50), 1.27 (95% CI, 1.12-1.44), and 1.70 (95% CI, 1.45-2.00) for ischemic stroke, respectively. Among women, the corresponding hazard ratios were 1.87 (95% CI, 1.12-3.14), 1.08 (95% CI, 0.95-1.22), and 1.30 (95% CI, 1.14-1.50) for total stroke, and 1.81 (95% CI, 0.97-3.41), 1.11 (95% CI, 0.96-1.28), and 1.41 (95% CI, 1.21-1.64) for ischemic stroke. Abdominal adiposity, defined as the highest quartile of waist circumference or waist-hip ratio, was associated with a greater risk of total and ischemic stroke in men but not in women. CONCLUSIONS: Body mass index was a risk factor for total and ischemic stroke in men and women. Abdominal adiposity was a risk factor for total and ischemic stroke only in men. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/17620537/Body_mass_index_waist_circumference_and_waist_hip_ratio_on_the_risk_of_total_and_type_specific_stroke_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinte.167.13.1420 DB - PRIME DP - Unbound Medicine ER -