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Efficacy of azithromycin versus systemic meglumine antimoniate (Glucantime) in the treatment of cutaneous leishmaniasis.
Am J Trop Med Hyg. 2007 Jul; 77(1):99-101.AJ

Abstract

Cutaneous leishmaniasis (CL) treatment is painful, and cosmetic results are often unsatisfying. Azithromycin has been reported to be effective in treatment of CL caused by Leishmania viannia braziliensis. The efficacy of azithromycin was compared with Glucantime in treatment of Old World leishmaniasis. Of 49 patients, 22 received 500 mg/day azithromycin for 5 days/month. Treatment cycles were repeated monthly to a maximum of 4 months; 27 patients received 60 mg/kg intramuscular meglumine antimoniate for 20 days. Both groups were followed up for 16 weeks. In the azithromycin group, 2 patients withdrew because of GI symptoms. The response rates of 20 patients (29 lesions) were as follows: full improvement, 10.3%; partial improvement, 27.6%; and 62.1%, no response. In the glucantime group with 27 patients (58 lesions), these rates were 34.4%, 13.8%, and 51.7%, respectively (P = 0.036). Azithromycin was determined to be not as effective as Glucantime in treatment of Old World CL.

Authors+Show Affiliations

Qaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. Pouran_layegh@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17620637

Citation

Layegh, Pouran, et al. "Efficacy of Azithromycin Versus Systemic Meglumine Antimoniate (Glucantime) in the Treatment of Cutaneous Leishmaniasis." The American Journal of Tropical Medicine and Hygiene, vol. 77, no. 1, 2007, pp. 99-101.
Layegh P, Yazdanpanah MJ, Vosugh EM, et al. Efficacy of azithromycin versus systemic meglumine antimoniate (Glucantime) in the treatment of cutaneous leishmaniasis. Am J Trop Med Hyg. 2007;77(1):99-101.
Layegh, P., Yazdanpanah, M. J., Vosugh, E. M., Pezeshkpoor, F., Shakeri, M. T., & Moghiman, T. (2007). Efficacy of azithromycin versus systemic meglumine antimoniate (Glucantime) in the treatment of cutaneous leishmaniasis. The American Journal of Tropical Medicine and Hygiene, 77(1), 99-101.
Layegh P, et al. Efficacy of Azithromycin Versus Systemic Meglumine Antimoniate (Glucantime) in the Treatment of Cutaneous Leishmaniasis. Am J Trop Med Hyg. 2007;77(1):99-101. PubMed PMID: 17620637.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of azithromycin versus systemic meglumine antimoniate (Glucantime) in the treatment of cutaneous leishmaniasis. AU - Layegh,Pouran, AU - Yazdanpanah,Mohammad Javad, AU - Vosugh,Elham Mohammadi, AU - Pezeshkpoor,Fakhrozaman, AU - Shakeri,Mohamad Taghi, AU - Moghiman,Toktam, PY - 2007/7/11/pubmed PY - 2007/9/21/medline PY - 2007/7/11/entrez SP - 99 EP - 101 JF - The American journal of tropical medicine and hygiene JO - Am J Trop Med Hyg VL - 77 IS - 1 N2 - Cutaneous leishmaniasis (CL) treatment is painful, and cosmetic results are often unsatisfying. Azithromycin has been reported to be effective in treatment of CL caused by Leishmania viannia braziliensis. The efficacy of azithromycin was compared with Glucantime in treatment of Old World leishmaniasis. Of 49 patients, 22 received 500 mg/day azithromycin for 5 days/month. Treatment cycles were repeated monthly to a maximum of 4 months; 27 patients received 60 mg/kg intramuscular meglumine antimoniate for 20 days. Both groups were followed up for 16 weeks. In the azithromycin group, 2 patients withdrew because of GI symptoms. The response rates of 20 patients (29 lesions) were as follows: full improvement, 10.3%; partial improvement, 27.6%; and 62.1%, no response. In the glucantime group with 27 patients (58 lesions), these rates were 34.4%, 13.8%, and 51.7%, respectively (P = 0.036). Azithromycin was determined to be not as effective as Glucantime in treatment of Old World CL. SN - 0002-9637 UR - https://www.unboundmedicine.com/medline/citation/17620637/Efficacy_of_azithromycin_versus_systemic_meglumine_antimoniate__Glucantime__in_the_treatment_of_cutaneous_leishmaniasis_ L2 - http://www.diseaseinfosearch.org/result/4166 DB - PRIME DP - Unbound Medicine ER -