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Brain tumor enhancement in MR imaging at 3 Tesla: comparison of SNR and CNR gain using TSE and GRE techniques.
Invest Radiol. 2007 Aug; 42(8):558-63.IR

Abstract

PURPOSE

The purpose of this study was to compare brain and tumor signal characteristics of T1-weighted turbo spin-echo (TSE) and gradient recalled echo (GRE) sequence techniques at 3 T compared to TSE at 1.5 T, focusing on the detection of contrast enhancement, in a standardized animal model of a brain glioma.

MATERIALS AND METHODS

Twelve rats with implanted brain gliomas were evaluated at 1.5 and 3 T using matched hardware configurations. At 1.5 T, scanning was performed using a TSE sequence optimized for field strength (480/15 milliseconds; 125 Hz/Px) with postcontrast scans acquired at multiple time points after gadoteridol injection (0.1 mmol/kg). At 3 T, scanning was performed using the 1.5 T equivalent TSE as well as with TSE and GRE techniques optimized for 3 T. Signal-to-noise ratio (SNR) of brain and tumor and tumor contrast-to-noise ratio (CNR) were evaluated for all techniques at both field strengths.

RESULTS

Postcontrast tumor SNR (63.7 +/- 10.8 vs. 29.5 +/- 4.3; P < 0.0001) and brain SNR (35.8 +/- 1.5 vs. 19.1 +/- 0.7; P < 0.0001) showed significant increase at 3 T using matched TSE. Comparing TSE optimized to each field strength (for optimized gray-white contrast), tumor and brain SNR still showed a significant increase at 3 T of 73% and 56%, respectively (both P < 0.0001). Comparing TSE at 1.5 T and GRE at 3 T, tumor SNR increased by 105%, whereas brain SNR increased by 141% (both P < 0.0001). Tumor CNR with matched TSE increased by 168% (P < 0.0001), with optimized TSE by 111% (P < 0.0001), and with GRE at 3 T versus TSE at 1.5 T by 36% (P < 0.001). With additional adjustments for echo time the gain in tumor CNR for 2D GRE may again reach 60%.

CONCLUSIONS

With TSE at 3 T, the SNR gain comes close to the theoretically expected doubling with an even higher tumor CNR increase. In a clinical like setting at 3 T, where a T1w GRE sequence is used, tumor CNR gain is limited. Contrast dose should therefore not be decreased at 3 T.

Authors+Show Affiliations

Department of Clinical Radiology, University Hospitals Grosshadern, Ludwig-Maximilians-University, Munich, Germany. bernd.wintersperger@med.uni-muenchen.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17620938

Citation

Wintersperger, Bernd J., et al. "Brain Tumor Enhancement in MR Imaging at 3 Tesla: Comparison of SNR and CNR Gain Using TSE and GRE Techniques." Investigative Radiology, vol. 42, no. 8, 2007, pp. 558-63.
Wintersperger BJ, Runge VM, Biswas J, et al. Brain tumor enhancement in MR imaging at 3 Tesla: comparison of SNR and CNR gain using TSE and GRE techniques. Invest Radiol. 2007;42(8):558-63.
Wintersperger, B. J., Runge, V. M., Biswas, J., Reiser, M. F., & Schoenberg, S. O. (2007). Brain tumor enhancement in MR imaging at 3 Tesla: comparison of SNR and CNR gain using TSE and GRE techniques. Investigative Radiology, 42(8), 558-63.
Wintersperger BJ, et al. Brain Tumor Enhancement in MR Imaging at 3 Tesla: Comparison of SNR and CNR Gain Using TSE and GRE Techniques. Invest Radiol. 2007;42(8):558-63. PubMed PMID: 17620938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brain tumor enhancement in MR imaging at 3 Tesla: comparison of SNR and CNR gain using TSE and GRE techniques. AU - Wintersperger,Bernd J, AU - Runge,Val M, AU - Biswas,Jonmenjoy, AU - Reiser,Maximilian F, AU - Schoenberg,Stefan O, PY - 2007/7/11/pubmed PY - 2007/11/8/medline PY - 2007/7/11/entrez SP - 558 EP - 63 JF - Investigative radiology JO - Invest Radiol VL - 42 IS - 8 N2 - PURPOSE: The purpose of this study was to compare brain and tumor signal characteristics of T1-weighted turbo spin-echo (TSE) and gradient recalled echo (GRE) sequence techniques at 3 T compared to TSE at 1.5 T, focusing on the detection of contrast enhancement, in a standardized animal model of a brain glioma. MATERIALS AND METHODS: Twelve rats with implanted brain gliomas were evaluated at 1.5 and 3 T using matched hardware configurations. At 1.5 T, scanning was performed using a TSE sequence optimized for field strength (480/15 milliseconds; 125 Hz/Px) with postcontrast scans acquired at multiple time points after gadoteridol injection (0.1 mmol/kg). At 3 T, scanning was performed using the 1.5 T equivalent TSE as well as with TSE and GRE techniques optimized for 3 T. Signal-to-noise ratio (SNR) of brain and tumor and tumor contrast-to-noise ratio (CNR) were evaluated for all techniques at both field strengths. RESULTS: Postcontrast tumor SNR (63.7 +/- 10.8 vs. 29.5 +/- 4.3; P < 0.0001) and brain SNR (35.8 +/- 1.5 vs. 19.1 +/- 0.7; P < 0.0001) showed significant increase at 3 T using matched TSE. Comparing TSE optimized to each field strength (for optimized gray-white contrast), tumor and brain SNR still showed a significant increase at 3 T of 73% and 56%, respectively (both P < 0.0001). Comparing TSE at 1.5 T and GRE at 3 T, tumor SNR increased by 105%, whereas brain SNR increased by 141% (both P < 0.0001). Tumor CNR with matched TSE increased by 168% (P < 0.0001), with optimized TSE by 111% (P < 0.0001), and with GRE at 3 T versus TSE at 1.5 T by 36% (P < 0.001). With additional adjustments for echo time the gain in tumor CNR for 2D GRE may again reach 60%. CONCLUSIONS: With TSE at 3 T, the SNR gain comes close to the theoretically expected doubling with an even higher tumor CNR increase. In a clinical like setting at 3 T, where a T1w GRE sequence is used, tumor CNR gain is limited. Contrast dose should therefore not be decreased at 3 T. SN - 0020-9996 UR - https://www.unboundmedicine.com/medline/citation/17620938/Brain_tumor_enhancement_in_MR_imaging_at_3_Tesla:_comparison_of_SNR_and_CNR_gain_using_TSE_and_GRE_techniques_ L2 - https://doi.org/10.1097/RLI.0b013e31803e8b3f DB - PRIME DP - Unbound Medicine ER -