TY - JOUR T1 - Effect of zinc supplementation on vitamin status of middle-aged and older European adults: the ZENITH study. AU - Intorre,F, AU - Polito,A, AU - Andriollo-Sanchez,M, AU - Azzini,E, AU - Raguzzini,A, AU - Toti,E, AU - Zaccaria,M, AU - Catasta,G, AU - Meunier,N, AU - Ducros,V, AU - O'Connor,J M, AU - Coudray,C, AU - Roussel,A M, AU - Maiani,G, Y1 - 2007/07/11/ PY - 2007/7/12/pubmed PY - 2009/1/13/medline PY - 2007/7/12/entrez SP - 1215 EP - 23 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 62 IS - 10 N2 - OBJECTIVE: To assess the effects of zinc supplementation on vitamin status in middle-aged and older volunteers. SUBJECTS/METHODS: Three hundred and eighty-seven healthy middle-aged (55-70 years) and older (70-85 years) men and women, randomly allocated to three groups to receive 15 or 30 mg Zn/day or placebo for 6 months. Dietary intake was assessed by means of a validated 4-day recall record. Fasting blood samples were simultaneously analysed for levels of plasma retinol and alpha-tocopherol by high-performance liquid chromatography. Erythrocyte folates were measured by a competitive immunoassay with direct chemiluminescence detection on an automatized immunoanalyser. Biochemical measurements were performed at baseline and after 3 and 6 months of zinc supplementation. RESULTS: Plasma vitamin A levels were significantly increased proportionally with zinc dose and period of treatment, particularly at 6 months (for 15 mg Zn/day, P<0.05; for 30 mg Zn/day, P<0.0001); no significant changes were observed in the placebo group. There was no effect of zinc supplementation on vitamin E/cholesterol ratio and erythrocyte folates. CONCLUSIONS: Our results show that a long-term zinc supplementation increases plasma vitamin A levels in middle-aged and older people of similar characteristics to those involved in this study. Moreover, supplementation influences serum zinc levels but does not affect erythrocyte zinc concentration and both plasma vitamin E and erythrocyte folate status. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/17622255/Effect_of_zinc_supplementation_on_vitamin_status_of_middle_aged_and_older_European_adults:_the_ZENITH_study_ L2 - https://doi.org/10.1038/sj.ejcn.1602844 DB - PRIME DP - Unbound Medicine ER -