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Plasma n-6 and n-3 polyunsaturated fatty acids as biomarkers of their dietary intakes: a cross-sectional study within a cohort of middle-aged French men and women.
Eur J Clin Nutr. 2008 Oct; 62(10):1155-61.EJ

Abstract

OBJECTIVE

To measure the correlations between habitual intakes of individual n-6 and n-3 polyunsaturated fatty acids (PUFA) and their percentages in total plasma fatty acids in a population of adult men and women.

SUBJECTS/METHODS

Two hundred and seventy-six men and 257 women aged 45-60 (men) or 35-60 (women) at baseline, volunteers of the French SU.VI.MAX cohort. Fifteen 24-h record questionnaires were used to estimate the habitual intake of energy, total fat and linoleic, alpha-linolenic acid, arachidonic, eicosapentaenoic (EPA), n-3 docosapentaenoic (DPA) and docosahexaenoic (DHA) acids. Fatty acid composition of fasting plasma total lipids has been determined at baseline.

RESULTS

Dietary intakes of linoleic acid, arachidonic acid, EPA and DHA were weakly but significantly correlated (0.16<r<0.28, P<0.01) with their respective percentages in plasma total fatty acids in both men and women. No correlation was observed between the plasma levels of alpha-linolenic acid and its dietary intake, and between the plasma levels of arachidonic acid and long-chain n-3 PUFA and the intakes of their 18-carbon precursors, linoleic and alpha-linolenic acid, respectively.

CONCLUSIONS

The percentages of linoleic acid, arachidonic acid, EPA and DHA in plasma total fatty acids, but not that of alpha-linolenic acid, are acceptable markers of their habitual levels of intake. The plasma levels of long-chain n-6 and n-3 PUFA are not influenced by the intake levels of their precursors, linoleic and alpha-linolenic acids.

Authors+Show Affiliations

Unité Nutrition et Régulation Lipidique des Fonctions Cérébrales (NuRéLiCe), INRA, Centre de Recherche de Jouy, Jouy-en-Josas, France. pierre.astorg@jouy.inra.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17622261

Citation

Astorg, P, et al. "Plasma N-6 and N-3 Polyunsaturated Fatty Acids as Biomarkers of Their Dietary Intakes: a Cross-sectional Study Within a Cohort of Middle-aged French Men and Women." European Journal of Clinical Nutrition, vol. 62, no. 10, 2008, pp. 1155-61.
Astorg P, Bertrais S, Laporte F, et al. Plasma n-6 and n-3 polyunsaturated fatty acids as biomarkers of their dietary intakes: a cross-sectional study within a cohort of middle-aged French men and women. Eur J Clin Nutr. 2008;62(10):1155-61.
Astorg, P., Bertrais, S., Laporte, F., Arnault, N., Estaquio, C., Galan, P., Favier, A., & Hercberg, S. (2008). Plasma n-6 and n-3 polyunsaturated fatty acids as biomarkers of their dietary intakes: a cross-sectional study within a cohort of middle-aged French men and women. European Journal of Clinical Nutrition, 62(10), 1155-61.
Astorg P, et al. Plasma N-6 and N-3 Polyunsaturated Fatty Acids as Biomarkers of Their Dietary Intakes: a Cross-sectional Study Within a Cohort of Middle-aged French Men and Women. Eur J Clin Nutr. 2008;62(10):1155-61. PubMed PMID: 17622261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma n-6 and n-3 polyunsaturated fatty acids as biomarkers of their dietary intakes: a cross-sectional study within a cohort of middle-aged French men and women. AU - Astorg,P, AU - Bertrais,S, AU - Laporte,F, AU - Arnault,N, AU - Estaquio,C, AU - Galan,P, AU - Favier,A, AU - Hercberg,S, Y1 - 2007/07/11/ PY - 2007/7/12/pubmed PY - 2009/1/13/medline PY - 2007/7/12/entrez SP - 1155 EP - 61 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 62 IS - 10 N2 - OBJECTIVE: To measure the correlations between habitual intakes of individual n-6 and n-3 polyunsaturated fatty acids (PUFA) and their percentages in total plasma fatty acids in a population of adult men and women. SUBJECTS/METHODS: Two hundred and seventy-six men and 257 women aged 45-60 (men) or 35-60 (women) at baseline, volunteers of the French SU.VI.MAX cohort. Fifteen 24-h record questionnaires were used to estimate the habitual intake of energy, total fat and linoleic, alpha-linolenic acid, arachidonic, eicosapentaenoic (EPA), n-3 docosapentaenoic (DPA) and docosahexaenoic (DHA) acids. Fatty acid composition of fasting plasma total lipids has been determined at baseline. RESULTS: Dietary intakes of linoleic acid, arachidonic acid, EPA and DHA were weakly but significantly correlated (0.16<r<0.28, P<0.01) with their respective percentages in plasma total fatty acids in both men and women. No correlation was observed between the plasma levels of alpha-linolenic acid and its dietary intake, and between the plasma levels of arachidonic acid and long-chain n-3 PUFA and the intakes of their 18-carbon precursors, linoleic and alpha-linolenic acid, respectively. CONCLUSIONS: The percentages of linoleic acid, arachidonic acid, EPA and DHA in plasma total fatty acids, but not that of alpha-linolenic acid, are acceptable markers of their habitual levels of intake. The plasma levels of long-chain n-6 and n-3 PUFA are not influenced by the intake levels of their precursors, linoleic and alpha-linolenic acids. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/17622261/Plasma_n_6_and_n_3_polyunsaturated_fatty_acids_as_biomarkers_of_their_dietary_intakes:_a_cross_sectional_study_within_a_cohort_of_middle_aged_French_men_and_women_ L2 - https://doi.org/10.1038/sj.ejcn.1602836 DB - PRIME DP - Unbound Medicine ER -