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Locally applied simvastatin promotes fracture healing in ovariectomized rat.
Osteoporos Int. 2007 Dec; 18(12):1641-50.OI

Abstract

Simvastatin solution was injected subcutaneously to the site of fractured tibiae of ovariectomized rats. Afterwards healing quality was evaluated by morphologic, radiographic, biomechanical, histological and histomorphometric methods at 1, 2 and 4 weeks after fracture. Results showed that locally applied simvastatin improved fracture healing.

INTRODUCTION

Many studies have documented an anabolic effect of hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, statins, on undisturbed bone. Reports of their effects, however, on fractured skeletal systems have been limited. A study was, therefore, conducted to check the effects of statins on fracture healing.

METHODS

Simvastatin (10 mg/kg/day) was injected subcutaneously to tissue overlying the site of fractured tibiae of ovariectomized rats for a treatment period of 5 days. Vehicle reagent was used as a control. Healing quality was evaluated at 1, 2 and 4 weeks after fracture.

RESULTS

Compared with that in the vehicle group, the callus cross-section area in simvastatin-treated rats was significantly enlarged by 21.3% (p < 0.05) at 1 week and by 21.5% (p < 0.05) at 2 weeks; new woven bone was relatively substantive and arranged more tightly and regularly at 2 and 4 weeks; and maximal load was increased by 57.5% (p < 0.05) at 2 weeks and by 31.4% (p < 0.05) at 4 weeks. Histomorphometrically, simvastatin was associated with a significant (p < 0.05) increase of mineralization width (MLW), mineralization volume (MLV) and mineral apposition rate (MAR).

CONCLUSION

The current study suggests that local application of simvastatin could promote fracture healing in ovariectomized rats.

Authors+Show Affiliations

Department of Orthopaedics, the Second Affiliated Hospital, Medical School of Zhejiang University, No.88, Jiefang Road, Hangzhou, China 310009.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17622479

Citation

Wang, J W., et al. "Locally Applied Simvastatin Promotes Fracture Healing in Ovariectomized Rat." Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, vol. 18, no. 12, 2007, pp. 1641-50.
Wang JW, Xu SW, Yang DS, et al. Locally applied simvastatin promotes fracture healing in ovariectomized rat. Osteoporos Int. 2007;18(12):1641-50.
Wang, J. W., Xu, S. W., Yang, D. S., & Lv, R. K. (2007). Locally applied simvastatin promotes fracture healing in ovariectomized rat. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 18(12), 1641-50.
Wang JW, et al. Locally Applied Simvastatin Promotes Fracture Healing in Ovariectomized Rat. Osteoporos Int. 2007;18(12):1641-50. PubMed PMID: 17622479.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Locally applied simvastatin promotes fracture healing in ovariectomized rat. AU - Wang,J W, AU - Xu,S W, AU - Yang,D S, AU - Lv,R K, Y1 - 2007/07/11/ PY - 2007/01/20/received PY - 2007/05/31/accepted PY - 2007/7/12/pubmed PY - 2008/2/28/medline PY - 2007/7/12/entrez SP - 1641 EP - 50 JF - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA JO - Osteoporos Int VL - 18 IS - 12 N2 - UNLABELLED: Simvastatin solution was injected subcutaneously to the site of fractured tibiae of ovariectomized rats. Afterwards healing quality was evaluated by morphologic, radiographic, biomechanical, histological and histomorphometric methods at 1, 2 and 4 weeks after fracture. Results showed that locally applied simvastatin improved fracture healing. INTRODUCTION: Many studies have documented an anabolic effect of hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, statins, on undisturbed bone. Reports of their effects, however, on fractured skeletal systems have been limited. A study was, therefore, conducted to check the effects of statins on fracture healing. METHODS: Simvastatin (10 mg/kg/day) was injected subcutaneously to tissue overlying the site of fractured tibiae of ovariectomized rats for a treatment period of 5 days. Vehicle reagent was used as a control. Healing quality was evaluated at 1, 2 and 4 weeks after fracture. RESULTS: Compared with that in the vehicle group, the callus cross-section area in simvastatin-treated rats was significantly enlarged by 21.3% (p < 0.05) at 1 week and by 21.5% (p < 0.05) at 2 weeks; new woven bone was relatively substantive and arranged more tightly and regularly at 2 and 4 weeks; and maximal load was increased by 57.5% (p < 0.05) at 2 weeks and by 31.4% (p < 0.05) at 4 weeks. Histomorphometrically, simvastatin was associated with a significant (p < 0.05) increase of mineralization width (MLW), mineralization volume (MLV) and mineral apposition rate (MAR). CONCLUSION: The current study suggests that local application of simvastatin could promote fracture healing in ovariectomized rats. SN - 0937-941X UR - https://www.unboundmedicine.com/medline/citation/17622479/Locally_applied_simvastatin_promotes_fracture_healing_in_ovariectomized_rat_ L2 - https://doi.org/10.1007/s00198-007-0412-2 DB - PRIME DP - Unbound Medicine ER -