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Effect of addition of yohimbine (alpha-2-receptor antagonist) to the antidepressant activity of fluoxetine or venlafaxine in the mouse forced swim test.
Pharmacology. 2007; 80(4):239-43.P

Abstract

BACKGROUND/AIMS

Studies have suggested that alpha(2)-adrenoceptors strongly affect monoaminergic neurotransmission by enhancing not only noradrenergic but also serotonergic firing rates. With this background in mind, the present study was undertaken to monitor the effect of addition of yohimbine (alpha(2)-adrenoceptor antagonist) to the effect of fluoxetine (selective serotonin reuptake inhibitor) or venlafaxine (dual reuptake inhibitors of both serotonin and norepinephrine) in Porsolt's forced swim test (FST) using male Laca strain mice.

METHOD

The immobility period was recorded in mouse FST during a 6-min period. Different doses of fluoxetine or venlafaxine were administered 30 min before exposing the animals to the test procedure. In the combination study, yohimbine (2 mg/kg i.p.) was administered 15 min before the administration of different doses of fluoxetine or venlafaxine.

RESULTS

Fluoxetine (5, 10, 20 and 40 mg/kg) [F = 28.352] or venlafaxine (2, 4, 8 and 16 mg/kg) [F = 17.842] dose-dependently inhibited the immobility period in mice. Addition of yohimbine (2 mg/kg i.p.) potentiated the antidepressant action of fluoxetine or venlafaxine in mouse FST as the animals showed a decrease in the immobility period compared to the fluoxetine or venlafaxine per se group, respectively.

CONCLUSION

The present study not only demonstrated the association of alpha(2)-receptors in the antidepressant effect of fluoxetine or venlafaxine, but also supports its adjuvant therapy with other antidepressant drugs.

Authors+Show Affiliations

Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17622775

Citation

Dhir, Ashish, and S K. Kulkarni. "Effect of Addition of Yohimbine (alpha-2-receptor Antagonist) to the Antidepressant Activity of Fluoxetine or Venlafaxine in the Mouse Forced Swim Test." Pharmacology, vol. 80, no. 4, 2007, pp. 239-43.
Dhir A, Kulkarni SK. Effect of addition of yohimbine (alpha-2-receptor antagonist) to the antidepressant activity of fluoxetine or venlafaxine in the mouse forced swim test. Pharmacology. 2007;80(4):239-43.
Dhir, A., & Kulkarni, S. K. (2007). Effect of addition of yohimbine (alpha-2-receptor antagonist) to the antidepressant activity of fluoxetine or venlafaxine in the mouse forced swim test. Pharmacology, 80(4), 239-43.
Dhir A, Kulkarni SK. Effect of Addition of Yohimbine (alpha-2-receptor Antagonist) to the Antidepressant Activity of Fluoxetine or Venlafaxine in the Mouse Forced Swim Test. Pharmacology. 2007;80(4):239-43. PubMed PMID: 17622775.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of addition of yohimbine (alpha-2-receptor antagonist) to the antidepressant activity of fluoxetine or venlafaxine in the mouse forced swim test. AU - Dhir,Ashish, AU - Kulkarni,S K, Y1 - 2007/07/06/ PY - 2007/02/09/received PY - 2007/02/15/accepted PY - 2007/7/12/pubmed PY - 2007/10/31/medline PY - 2007/7/12/entrez SP - 239 EP - 43 JF - Pharmacology JO - Pharmacology VL - 80 IS - 4 N2 - BACKGROUND/AIMS: Studies have suggested that alpha(2)-adrenoceptors strongly affect monoaminergic neurotransmission by enhancing not only noradrenergic but also serotonergic firing rates. With this background in mind, the present study was undertaken to monitor the effect of addition of yohimbine (alpha(2)-adrenoceptor antagonist) to the effect of fluoxetine (selective serotonin reuptake inhibitor) or venlafaxine (dual reuptake inhibitors of both serotonin and norepinephrine) in Porsolt's forced swim test (FST) using male Laca strain mice. METHOD: The immobility period was recorded in mouse FST during a 6-min period. Different doses of fluoxetine or venlafaxine were administered 30 min before exposing the animals to the test procedure. In the combination study, yohimbine (2 mg/kg i.p.) was administered 15 min before the administration of different doses of fluoxetine or venlafaxine. RESULTS: Fluoxetine (5, 10, 20 and 40 mg/kg) [F = 28.352] or venlafaxine (2, 4, 8 and 16 mg/kg) [F = 17.842] dose-dependently inhibited the immobility period in mice. Addition of yohimbine (2 mg/kg i.p.) potentiated the antidepressant action of fluoxetine or venlafaxine in mouse FST as the animals showed a decrease in the immobility period compared to the fluoxetine or venlafaxine per se group, respectively. CONCLUSION: The present study not only demonstrated the association of alpha(2)-receptors in the antidepressant effect of fluoxetine or venlafaxine, but also supports its adjuvant therapy with other antidepressant drugs. SN - 1423-0313 UR - https://www.unboundmedicine.com/medline/citation/17622775/Effect_of_addition_of_yohimbine__alpha_2_receptor_antagonist__to_the_antidepressant_activity_of_fluoxetine_or_venlafaxine_in_the_mouse_forced_swim_test_ L2 - https://www.karger.com?DOI=10.1159/000104877 DB - PRIME DP - Unbound Medicine ER -