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Protective effect of Lycium barbarum on doxorubicin-induced cardiotoxicity.
Phytother Res. 2007 Nov; 21(11):1020-4.PR

Abstract

The objective of this work was to explore the hypothesis that Lycium barbarum (LB) may be protective against doxorubicin (DOX)-induced cardiotoxicity through antioxidant-mediated mechanisms. Male SD rats were treated with distilled water or a water extract of LB (25 mg/kg, p.o.) daily and saline or DOX (5 mg/kg, i.v.) weekly for 3 weeks. Mortality, general condition and body weight were observed during the experiment. DOX-induced cardiotoxicity was assessed by electrocardiograph, heart antioxidant activity, serum levels of creatine kinase (CK) and aspartate aminotransferase (AST) and histopathological change. The DOX group showed higher mortality (38%) and worse physical characterization. Moreover, DOX caused myocardial injury manifested by arrhythmias and conduction abnormalities in ECG (increased QT and ST intervals and ST elevation), a decrease of heart antioxidant activity, an increase of serum CK and AST, as well as myocardial lesions. Pretreatment with LB significantly prevented the loss of myofibrils and improved the heart function of the DOX-treated rats as evidenced from lower mortality (13%), normalization of antioxidative activity and serum AST and CK, as well as improving arrhythmias and conduction abnormalities. These results suggested that LB elicited a typical cardioprotective effect on DOX-related oxidative stress. Furthermore, in vitro cytotoxic study showed the antitumor activity of DOX was not compromised by LB. It is possible that LB could be used as a useful adjunct in combination with DOX chemotherapy.

Authors+Show Affiliations

State Key Laboratory of Safety Evaluation for New Drug, Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17622973

Citation

Xin, Yan-Fei, et al. "Protective Effect of Lycium Barbarum On Doxorubicin-induced Cardiotoxicity." Phytotherapy Research : PTR, vol. 21, no. 11, 2007, pp. 1020-4.
Xin YF, Zhou GL, Deng ZY, et al. Protective effect of Lycium barbarum on doxorubicin-induced cardiotoxicity. Phytother Res. 2007;21(11):1020-4.
Xin, Y. F., Zhou, G. L., Deng, Z. Y., Chen, Y. X., Wu, Y. G., Xu, P. S., & Xuan, Y. X. (2007). Protective effect of Lycium barbarum on doxorubicin-induced cardiotoxicity. Phytotherapy Research : PTR, 21(11), 1020-4.
Xin YF, et al. Protective Effect of Lycium Barbarum On Doxorubicin-induced Cardiotoxicity. Phytother Res. 2007;21(11):1020-4. PubMed PMID: 17622973.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of Lycium barbarum on doxorubicin-induced cardiotoxicity. AU - Xin,Yan-Fei, AU - Zhou,Guo-Liang, AU - Deng,Zu-Yue, AU - Chen,Yun-Xiang, AU - Wu,Yue-Guo, AU - Xu,Pan-Sheng, AU - Xuan,Yao-Xian, PY - 2007/7/12/pubmed PY - 2008/2/21/medline PY - 2007/7/12/entrez SP - 1020 EP - 4 JF - Phytotherapy research : PTR JO - Phytother Res VL - 21 IS - 11 N2 - The objective of this work was to explore the hypothesis that Lycium barbarum (LB) may be protective against doxorubicin (DOX)-induced cardiotoxicity through antioxidant-mediated mechanisms. Male SD rats were treated with distilled water or a water extract of LB (25 mg/kg, p.o.) daily and saline or DOX (5 mg/kg, i.v.) weekly for 3 weeks. Mortality, general condition and body weight were observed during the experiment. DOX-induced cardiotoxicity was assessed by electrocardiograph, heart antioxidant activity, serum levels of creatine kinase (CK) and aspartate aminotransferase (AST) and histopathological change. The DOX group showed higher mortality (38%) and worse physical characterization. Moreover, DOX caused myocardial injury manifested by arrhythmias and conduction abnormalities in ECG (increased QT and ST intervals and ST elevation), a decrease of heart antioxidant activity, an increase of serum CK and AST, as well as myocardial lesions. Pretreatment with LB significantly prevented the loss of myofibrils and improved the heart function of the DOX-treated rats as evidenced from lower mortality (13%), normalization of antioxidative activity and serum AST and CK, as well as improving arrhythmias and conduction abnormalities. These results suggested that LB elicited a typical cardioprotective effect on DOX-related oxidative stress. Furthermore, in vitro cytotoxic study showed the antitumor activity of DOX was not compromised by LB. It is possible that LB could be used as a useful adjunct in combination with DOX chemotherapy. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/17622973/Protective_effect_of_Lycium_barbarum_on_doxorubicin_induced_cardiotoxicity_ L2 - https://doi.org/10.1002/ptr.2186 DB - PRIME DP - Unbound Medicine ER -