Tags

Type your tag names separated by a space and hit enter

Midlife risk factors for subtypes of dementia: a nested case-control study in Taiwan.

Abstract

OBJECTIVE

To identify the midlife risk factors for subtypes of dementia newly developed later in life.

METHODS

A nested case-control study was conducted on 157 demented cases and 628 comparison cases selected from 40,636 men and women who were enrolled from 1982 to 1992. Four comparison cases were frequency-matched on age, time at enrollment (within 6 months), gender, and residential township. Midlife risk factors included vascular risk factors (body mass index [BMI], total cholesterol, total triglycerides, blood glucose, cerebrovascular accident [CVA] history, diabetes mellitus history, and hypertension history), cigarette smoking, and alcohol consumption. Dementia assessments were ascertained through the computerized data linkage from National Health Insurance Database from 2000 to 2002 and clinically confirmed by neurologists or psychiatrists. Conditional logistic regression analysis was used to estimate the matched odds ratio (OR) and its 95% confidence intervals (CI) for each risk factor.

RESULTS

A J-shaped relationship was observed between BMI (kg/m(2)) and dementia. The multivariate-adjusted ORs (95% CI) of developing dementia were 1.84 (1.02-3.33), 1.87 (1.08-3.23) and 2.44 (1.39-4.28), respectively, for BMIs of <20.5, 23.0-25.4, >or=25.5 compared with a BMI of 20.5-22.9 as the referent group (OR = 1.0). Similar findings were observed for Alzheimer disease (AD) and vascular dementia (VaD). The association between obesity (BMI >or=25.5) and both AD and VaD was statistically significant among cigarette smokers but not among nonsmokers. Additionally, history of CVA was a significant risk factor for VaD, but not for AD.

CONCLUSION

Being underweight, being overweight, and a cerebrovascular accident in midlife may increase the risk of dementia in late life.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan.

    , , , , , , , , , , , , , , , ,

    Source

    MeSH

    Aged
    Alcohol Drinking
    Alzheimer Disease
    Blood Glucose
    Body Mass Index
    Case-Control Studies
    Cholesterol
    Cohort Studies
    Data Collection
    Dementia
    Dementia, Vascular
    Diabetes Mellitus
    Female
    Geriatric Assessment
    Humans
    Hypercholesterolemia
    Hypertension
    Male
    Mass Screening
    Middle Aged
    Risk Factors
    Smoking
    Statistics as Topic
    Stroke
    Taiwan
    Triglycerides

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    17623813

    Citation

    Chiang, Chun-Ju, et al. "Midlife Risk Factors for Subtypes of Dementia: a Nested Case-control Study in Taiwan." The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, vol. 15, no. 9, 2007, pp. 762-71.
    Chiang CJ, Yip PK, Wu SC, et al. Midlife risk factors for subtypes of dementia: a nested case-control study in Taiwan. Am J Geriatr Psychiatry. 2007;15(9):762-71.
    Chiang, C. J., Yip, P. K., Wu, S. C., Lu, C. S., Liou, C. W., Liu, H. C., ... Chen, C. J. (2007). Midlife risk factors for subtypes of dementia: a nested case-control study in Taiwan. The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, 15(9), pp. 762-71.
    Chiang CJ, et al. Midlife Risk Factors for Subtypes of Dementia: a Nested Case-control Study in Taiwan. Am J Geriatr Psychiatry. 2007;15(9):762-71. PubMed PMID: 17623813.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Midlife risk factors for subtypes of dementia: a nested case-control study in Taiwan. AU - Chiang,Chun-Ju, AU - Yip,Ping-Keung, AU - Wu,Shiao-Chi, AU - Lu,Chin-Song, AU - Liou,Chia-Wei, AU - Liu,Hsiu-Chih, AU - Liu,Ching-Kuan, AU - Chu,Ching-Hua, AU - Hwang,Chi-Shin, AU - Sung,Sheng-Feng, AU - Hsu,Yaw-Don, AU - Chen,Cheng-Chung, AU - Liu,Shen-Ing, AU - Yan,Sui-Hing, AU - Fong,Chin-Shih, AU - Chang,Shu-Feng, AU - You,San-Lin, AU - Chen,Chien-Jen, Y1 - 2007/07/10/ PY - 2007/7/12/pubmed PY - 2007/12/6/medline PY - 2007/7/12/entrez SP - 762 EP - 71 JF - The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry JO - Am J Geriatr Psychiatry VL - 15 IS - 9 N2 - OBJECTIVE: To identify the midlife risk factors for subtypes of dementia newly developed later in life. METHODS: A nested case-control study was conducted on 157 demented cases and 628 comparison cases selected from 40,636 men and women who were enrolled from 1982 to 1992. Four comparison cases were frequency-matched on age, time at enrollment (within 6 months), gender, and residential township. Midlife risk factors included vascular risk factors (body mass index [BMI], total cholesterol, total triglycerides, blood glucose, cerebrovascular accident [CVA] history, diabetes mellitus history, and hypertension history), cigarette smoking, and alcohol consumption. Dementia assessments were ascertained through the computerized data linkage from National Health Insurance Database from 2000 to 2002 and clinically confirmed by neurologists or psychiatrists. Conditional logistic regression analysis was used to estimate the matched odds ratio (OR) and its 95% confidence intervals (CI) for each risk factor. RESULTS: A J-shaped relationship was observed between BMI (kg/m(2)) and dementia. The multivariate-adjusted ORs (95% CI) of developing dementia were 1.84 (1.02-3.33), 1.87 (1.08-3.23) and 2.44 (1.39-4.28), respectively, for BMIs of <20.5, 23.0-25.4, >or=25.5 compared with a BMI of 20.5-22.9 as the referent group (OR = 1.0). Similar findings were observed for Alzheimer disease (AD) and vascular dementia (VaD). The association between obesity (BMI >or=25.5) and both AD and VaD was statistically significant among cigarette smokers but not among nonsmokers. Additionally, history of CVA was a significant risk factor for VaD, but not for AD. CONCLUSION: Being underweight, being overweight, and a cerebrovascular accident in midlife may increase the risk of dementia in late life. SN - 1064-7481 UR - https://www.unboundmedicine.com/medline/citation/17623813/Midlife_risk_factors_for_subtypes_of_dementia:_a_nested_case_control_study_in_Taiwan_ L2 - https://linkinghub.elsevier.com/retrieve/pii/JGP.0b013e318050c98f DB - PRIME DP - Unbound Medicine ER -