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Development and validation of the Cozart DDS oral fluid collection device.
Forensic Sci Int. 2007 Aug 06; 170(2-3):117-20.FS

Abstract

The testing of oral fluid for drugs of abuse has increased significantly over recent years and is now commonplace in drug rehabilitation clinics, the workplace, prisons and custody suites. The global problem of identifying drugged drivers has also led to an increase in oral fluid testing at the roadside. The main requirements for the implementation of roadside drug testing are a rapid sample collection time, collection of a known sample volume and recovery of drugs from the collection device. We report here the development of the Cozart DDS oral fluid collector, an oral fluid collector that combines rapid and adequate sample collection with satisfactory drug recovery. Oral fluid was collected from drug users (n=134) and drug-free individuals (n=137), using the Cozart DDS oral fluid collector. The mean time for the completion of collection (full coloration of the sample presence indicator) was 34 s for drug-free individuals and 44 s for drug users. The average volume collected was 0.34 mL (n=271). No chemical stimulant (to induce salivation) was used to achieve the collection times observed in either the drug-free or the drug-taking sample populations. Drugs were extracted from the collector using the Cozart DDS buffer and drug recovery was determined by Cozart enzyme immunoassays. The recovery studies showed that for amphetamine, Delta(9)THC, cocaine, methadone, methamphetamine, morphine and temazepam over 90% of the drug in the sample was eluted from the collector. The Cozart DDS oral fluid collector provides a reliable mechanism for the collection of oral fluid at the roadside that achieves the rapid collection times required.

Authors+Show Affiliations

Cozart Bioscience Ltd., Abingdon, Oxfordshire, United Kingdom. tspeedy@cozart.co.uk <tspeedy@cozart.co.uk>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Validation Study

Language

eng

PubMed ID

17624706

Citation

Speedy, T, et al. "Development and Validation of the Cozart DDS Oral Fluid Collection Device." Forensic Science International, vol. 170, no. 2-3, 2007, pp. 117-20.
Speedy T, Baldwin D, Jowett G, et al. Development and validation of the Cozart DDS oral fluid collection device. Forensic Sci Int. 2007;170(2-3):117-20.
Speedy, T., Baldwin, D., Jowett, G., Gallina, M., & Jehanli, A. (2007). Development and validation of the Cozart DDS oral fluid collection device. Forensic Science International, 170(2-3), 117-20.
Speedy T, et al. Development and Validation of the Cozart DDS Oral Fluid Collection Device. Forensic Sci Int. 2007 Aug 6;170(2-3):117-20. PubMed PMID: 17624706.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development and validation of the Cozart DDS oral fluid collection device. AU - Speedy,T, AU - Baldwin,D, AU - Jowett,G, AU - Gallina,M, AU - Jehanli,A, Y1 - 2007/07/12/ PY - 2006/09/30/received PY - 2007/03/10/revised PY - 2007/03/14/accepted PY - 2007/7/13/pubmed PY - 2007/10/19/medline PY - 2007/7/13/entrez SP - 117 EP - 20 JF - Forensic science international JO - Forensic Sci. Int. VL - 170 IS - 2-3 N2 - The testing of oral fluid for drugs of abuse has increased significantly over recent years and is now commonplace in drug rehabilitation clinics, the workplace, prisons and custody suites. The global problem of identifying drugged drivers has also led to an increase in oral fluid testing at the roadside. The main requirements for the implementation of roadside drug testing are a rapid sample collection time, collection of a known sample volume and recovery of drugs from the collection device. We report here the development of the Cozart DDS oral fluid collector, an oral fluid collector that combines rapid and adequate sample collection with satisfactory drug recovery. Oral fluid was collected from drug users (n=134) and drug-free individuals (n=137), using the Cozart DDS oral fluid collector. The mean time for the completion of collection (full coloration of the sample presence indicator) was 34 s for drug-free individuals and 44 s for drug users. The average volume collected was 0.34 mL (n=271). No chemical stimulant (to induce salivation) was used to achieve the collection times observed in either the drug-free or the drug-taking sample populations. Drugs were extracted from the collector using the Cozart DDS buffer and drug recovery was determined by Cozart enzyme immunoassays. The recovery studies showed that for amphetamine, Delta(9)THC, cocaine, methadone, methamphetamine, morphine and temazepam over 90% of the drug in the sample was eluted from the collector. The Cozart DDS oral fluid collector provides a reliable mechanism for the collection of oral fluid at the roadside that achieves the rapid collection times required. SN - 1872-6283 UR - https://www.unboundmedicine.com/medline/citation/17624706/Development_and_validation_of_the_Cozart_DDS_oral_fluid_collection_device_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0379-0738(07)00564-6 DB - PRIME DP - Unbound Medicine ER -