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Prostate cancer survival is dependent on season of diagnosis.
Prostate. 2007 Sep 01; 67(12):1362-70.P

Abstract

BACKGROUND

We have earlier found that the prognosis for several cancers is dependent on season of diagnosis. More recently, both prostate cancer incidence and mortality have been shown to increase with increasing latitude, which probably relates to photosynthesis of vitamin D.

METHODS

The 3 year survival of prostate cancer patients has been analyzed with the Cox regression method for two age groups at different latitudes in Norway.

RESULTS

Patients diagnosed during the summer and autumn had the best prognosis (Ralative risk (RR) death 0.8; 95% CI 0.75-0.85). Similar results were observed in three regions of the country that differ with respect to annual fluences of solar UV radiation, incidence rates of squamous cell carcinoma (SCC) and intake of fish. Furthermore, similar relationship between the season and survival was seen among patients </=65 years and >65 years old, although the younger group had a slightly larger advantage of summer and autumn diagnosis.

CONCLUSIONS

The seasonal effect on prognosis may be related to the seasonal variations of calcidiol (the marker of vitamin D status). The lack of latitude effect and the similarity of prognosis for different age groups may be related to higher consumption of vitamin D in food in the north region and to increase of such consumption with age.

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Authors+Show Affiliations

Lagunova Z
Department of Radiation Biology, Institute for Cancer Research, Montebello, Oslo, Norway. zoya.lagunova@medisin.uio.no
Porojnicu AC
No affiliation info available
Dahlback A
No affiliation info available
Berg JP
No affiliation info available
Beer TM
No affiliation info available
Moan J
No affiliation info available

MeSH

AgedAnimalsCalcifediolCarcinoma, Squamous CellDietFishesHumansIncidenceMaleMiddle AgedNorwayProstatic NeoplasmsSeasonsSunlightSurvival Analysis

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17624920

Citation

Lagunova, Zoya, et al. "Prostate Cancer Survival Is Dependent On Season of Diagnosis." The Prostate, vol. 67, no. 12, 2007, pp. 1362-70.
Lagunova Z, Porojnicu AC, Dahlback A, et al. Prostate cancer survival is dependent on season of diagnosis. Prostate. 2007;67(12):1362-70.
Lagunova, Z., Porojnicu, A. C., Dahlback, A., Berg, J. P., Beer, T. M., & Moan, J. (2007). Prostate cancer survival is dependent on season of diagnosis. The Prostate, 67(12), 1362-70.
Lagunova Z, et al. Prostate Cancer Survival Is Dependent On Season of Diagnosis. Prostate. 2007 Sep 1;67(12):1362-70. PubMed PMID: 17624920.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prostate cancer survival is dependent on season of diagnosis. AU - Lagunova,Zoya, AU - Porojnicu,Alina Carmen, AU - Dahlback,Arne, AU - Berg,Jens Petter, AU - Beer,Tomasz M, AU - Moan,Johan, PY - 2007/7/13/pubmed PY - 2007/10/27/medline PY - 2007/7/13/entrez SP - 1362 EP - 70 JF - The Prostate JO - Prostate VL - 67 IS - 12 N2 - BACKGROUND: We have earlier found that the prognosis for several cancers is dependent on season of diagnosis. More recently, both prostate cancer incidence and mortality have been shown to increase with increasing latitude, which probably relates to photosynthesis of vitamin D. METHODS: The 3 year survival of prostate cancer patients has been analyzed with the Cox regression method for two age groups at different latitudes in Norway. RESULTS: Patients diagnosed during the summer and autumn had the best prognosis (Ralative risk (RR) death 0.8; 95% CI 0.75-0.85). Similar results were observed in three regions of the country that differ with respect to annual fluences of solar UV radiation, incidence rates of squamous cell carcinoma (SCC) and intake of fish. Furthermore, similar relationship between the season and survival was seen among patients </=65 years and >65 years old, although the younger group had a slightly larger advantage of summer and autumn diagnosis. CONCLUSIONS: The seasonal effect on prognosis may be related to the seasonal variations of calcidiol (the marker of vitamin D status). The lack of latitude effect and the similarity of prognosis for different age groups may be related to higher consumption of vitamin D in food in the north region and to increase of such consumption with age. SN - 0270-4137 UR - https://www.unboundmedicine.com/medline/citation/17624920/Prostate_cancer_survival_is_dependent_on_season_of_diagnosis_ L2 - https://doi.org/10.1002/pros.20577 DB - PRIME DP - Unbound Medicine ER -