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[Helicobacter pylori infection and its metabolic consequences in children and adolescents with type 1 diabetes mellitus].
Med Wieku Rozwoj 2007 Apr-Jun; 11(2 Pt 1):103-8MW

Abstract

Helicobacter pylori infection (Hp) is the cause of chronic gastritis and duodenitis, ulcer disease, and functional gastrointestinal motor disorders. Its prevalence among Polish children with type 1 diabetes mellitus has been estimated at 25%. There is limited data regarding the influence of Helicobacter pylori infection on clinical course of diabetes, with controversial results.

THE AIM

of the study was the estimation of Helicobacter pylori infection on the quality of metabolic control in children and adolescents with type 1 diabetes mellitus.

MATERIAL AND METHODS

198 diabetic patients were investigated (mean age 14.38+/-3.75; range 4.5-25 years), with diabetes duration of 4.91+/-4.21 years (range 0.5-16 years). Screening for Helicobacter pylori infection was performed utilizing the urea breath test (UBTC13); DOB (delta over the baseline) above 3%o was considered positive. Metabolic control included HbA1c (HPLC; Bio-Rad, Munich, Germany) and glucose concentration measurement; glycemia was expressed as area under the curve in fasting and prandial state (AUC).

RESULTS

UBT was positive in 48 (24.3%) diabetic patients. HbA1c concentration was significantly higher in patients with Helicobacter pylori infection (7.87+/-1.51 vs. 7.17+/-1.46%; p<0.05). The AUC values were higher in Hp positive diabetic subjects: AUCO 83.75+/-40.99 vs. 66.82+/-31.71 and AUC1 189.86+/-61.57 vs. 149.02+/-51.66 [mg% x 0.5h x 0.5]; p<0.05.

CONCLUSIONS

1. Helicobacter pylori infection significantly worsens metabolic control in children and adolescents with type 1 diabetes mellitus. 2. High prevalence of Helicobacter pylori infection among young diabetic subjects and its influence on glucose control legitimate the screening for Hp inpatients with poor metabolic control of diabetes.

Authors+Show Affiliations

Klinika Alergologii, Gastroenterologii i Zywienia Dzieci III Katedry Pediatrii UM, ul. Sporna 36/50, 91-738 Lodz, Poland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

pol

PubMed ID

17625277

Citation

Toporowska-Kowalska, Ewa, et al. "[Helicobacter Pylori Infection and Its Metabolic Consequences in Children and Adolescents With Type 1 Diabetes Mellitus]." Medycyna Wieku Rozwojowego, vol. 11, no. 2 Pt 1, 2007, pp. 103-8.
Toporowska-Kowalska E, Wasowska-Królikowska K, Szadkowska A, et al. [Helicobacter pylori infection and its metabolic consequences in children and adolescents with type 1 diabetes mellitus]. Med Wieku Rozwoj. 2007;11(2 Pt 1):103-8.
Toporowska-Kowalska, E., Wasowska-Królikowska, K., Szadkowska, A., & Bodalski, J. (2007). [Helicobacter pylori infection and its metabolic consequences in children and adolescents with type 1 diabetes mellitus]. Medycyna Wieku Rozwojowego, 11(2 Pt 1), pp. 103-8.
Toporowska-Kowalska E, et al. [Helicobacter Pylori Infection and Its Metabolic Consequences in Children and Adolescents With Type 1 Diabetes Mellitus]. Med Wieku Rozwoj. 2007;11(2 Pt 1):103-8. PubMed PMID: 17625277.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Helicobacter pylori infection and its metabolic consequences in children and adolescents with type 1 diabetes mellitus]. AU - Toporowska-Kowalska,Ewa, AU - Wasowska-Królikowska,Krystyna, AU - Szadkowska,Agnieszka, AU - Bodalski,Jerzy, PY - 2007/7/13/pubmed PY - 2007/9/28/medline PY - 2007/7/13/entrez SP - 103 EP - 8 JF - Medycyna wieku rozwojowego JO - Med Wieku Rozwoj VL - 11 IS - 2 Pt 1 N2 - UNLABELLED: Helicobacter pylori infection (Hp) is the cause of chronic gastritis and duodenitis, ulcer disease, and functional gastrointestinal motor disorders. Its prevalence among Polish children with type 1 diabetes mellitus has been estimated at 25%. There is limited data regarding the influence of Helicobacter pylori infection on clinical course of diabetes, with controversial results. THE AIM: of the study was the estimation of Helicobacter pylori infection on the quality of metabolic control in children and adolescents with type 1 diabetes mellitus. MATERIAL AND METHODS: 198 diabetic patients were investigated (mean age 14.38+/-3.75; range 4.5-25 years), with diabetes duration of 4.91+/-4.21 years (range 0.5-16 years). Screening for Helicobacter pylori infection was performed utilizing the urea breath test (UBTC13); DOB (delta over the baseline) above 3%o was considered positive. Metabolic control included HbA1c (HPLC; Bio-Rad, Munich, Germany) and glucose concentration measurement; glycemia was expressed as area under the curve in fasting and prandial state (AUC). RESULTS: UBT was positive in 48 (24.3%) diabetic patients. HbA1c concentration was significantly higher in patients with Helicobacter pylori infection (7.87+/-1.51 vs. 7.17+/-1.46%; p<0.05). The AUC values were higher in Hp positive diabetic subjects: AUCO 83.75+/-40.99 vs. 66.82+/-31.71 and AUC1 189.86+/-61.57 vs. 149.02+/-51.66 [mg% x 0.5h x 0.5]; p<0.05. CONCLUSIONS: 1. Helicobacter pylori infection significantly worsens metabolic control in children and adolescents with type 1 diabetes mellitus. 2. High prevalence of Helicobacter pylori infection among young diabetic subjects and its influence on glucose control legitimate the screening for Hp inpatients with poor metabolic control of diabetes. UR - https://www.unboundmedicine.com/medline/citation/17625277/[Helicobacter_pylori_infection_and_its_metabolic_consequences_in_children_and_adolescents_with_type_1_diabetes_mellitus]_ L2 - http://www.diseaseinfosearch.org/result/8214 DB - PRIME DP - Unbound Medicine ER -