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New insights into the role of lipoprotein(a)-associated lipoprotein-associated phospholipase A2 in atherosclerosis and cardiovascular disease.
Arterioscler Thromb Vasc Biol. 2007 Oct; 27(10):2094-9.AT

Abstract

Lipoprotein(a) [Lp(a)] plays an important role in atherosclerosis. The biological effects of Lp(a) have been attributed either to apolipoprotein(a) or to its low-density lipoprotein-like particle. Lp(a) contains platelet-activating factor acetylhydrolase, an enzyme that exhibits a Ca2+-independent phospholipase A2 activity and is complexed to lipoproteins in plasma; thus, it is also referred to as lipoprotein-associated phospholipase A2. Substrates for lipoprotein-associated phospholipase A2 include phospholipids containing oxidatively fragmented residues at the sn-2 position (oxidized phospholipids; OxPLs). OxPLs may play important roles in vascular inflammation and atherosclerosis. Plasma levels of OxPLs present on apolipoprotein B-100 particles (OxPL/apolipoprotein B) are correlated with coronary artery, carotid, and peripheral arterial disease. Furthermore, OxPL/apolipoprotein B levels in plasma are strongly correlated with Lp(a) levels, are preferentially sequestered on Lp(a), and thus are potentially subjected to degradation by the Lp(a)-associated lipoprotein-associated phospholipase A2. The present review article focuses specifically on the characteristics of the lipoprotein-associated phospholipase A2 associated with Lp(a) and discusses the possible role of this enzyme in view of emerging data showing that OxPLs in plasma are preferentially sequestered on Lp(a) and may significantly contribute to the increased atherogenicity of this lipoprotein.

Authors+Show Affiliations

Department of Medicine, University of California San Diego, La Jolla, Calif, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17626905

Citation

Tsimikas, Sotirios, et al. "New Insights Into the Role of Lipoprotein(a)-associated Lipoprotein-associated Phospholipase A2 in Atherosclerosis and Cardiovascular Disease." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 27, no. 10, 2007, pp. 2094-9.
Tsimikas S, Tsironis LD, Tselepis AD. New insights into the role of lipoprotein(a)-associated lipoprotein-associated phospholipase A2 in atherosclerosis and cardiovascular disease. Arterioscler Thromb Vasc Biol. 2007;27(10):2094-9.
Tsimikas, S., Tsironis, L. D., & Tselepis, A. D. (2007). New insights into the role of lipoprotein(a)-associated lipoprotein-associated phospholipase A2 in atherosclerosis and cardiovascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 27(10), 2094-9.
Tsimikas S, Tsironis LD, Tselepis AD. New Insights Into the Role of Lipoprotein(a)-associated Lipoprotein-associated Phospholipase A2 in Atherosclerosis and Cardiovascular Disease. Arterioscler Thromb Vasc Biol. 2007;27(10):2094-9. PubMed PMID: 17626905.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New insights into the role of lipoprotein(a)-associated lipoprotein-associated phospholipase A2 in atherosclerosis and cardiovascular disease. AU - Tsimikas,Sotirios, AU - Tsironis,Loukas D, AU - Tselepis,Alexandros D, Y1 - 2007/07/12/ PY - 2007/7/14/pubmed PY - 2007/10/12/medline PY - 2007/7/14/entrez SP - 2094 EP - 9 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler. Thromb. Vasc. Biol. VL - 27 IS - 10 N2 - Lipoprotein(a) [Lp(a)] plays an important role in atherosclerosis. The biological effects of Lp(a) have been attributed either to apolipoprotein(a) or to its low-density lipoprotein-like particle. Lp(a) contains platelet-activating factor acetylhydrolase, an enzyme that exhibits a Ca2+-independent phospholipase A2 activity and is complexed to lipoproteins in plasma; thus, it is also referred to as lipoprotein-associated phospholipase A2. Substrates for lipoprotein-associated phospholipase A2 include phospholipids containing oxidatively fragmented residues at the sn-2 position (oxidized phospholipids; OxPLs). OxPLs may play important roles in vascular inflammation and atherosclerosis. Plasma levels of OxPLs present on apolipoprotein B-100 particles (OxPL/apolipoprotein B) are correlated with coronary artery, carotid, and peripheral arterial disease. Furthermore, OxPL/apolipoprotein B levels in plasma are strongly correlated with Lp(a) levels, are preferentially sequestered on Lp(a), and thus are potentially subjected to degradation by the Lp(a)-associated lipoprotein-associated phospholipase A2. The present review article focuses specifically on the characteristics of the lipoprotein-associated phospholipase A2 associated with Lp(a) and discusses the possible role of this enzyme in view of emerging data showing that OxPLs in plasma are preferentially sequestered on Lp(a) and may significantly contribute to the increased atherogenicity of this lipoprotein. SN - 1524-4636 UR - https://www.unboundmedicine.com/medline/citation/17626905/New_insights_into_the_role_of_lipoprotein_a__associated_lipoprotein_associated_phospholipase_A2_in_atherosclerosis_and_cardiovascular_disease_ L2 - http://www.ahajournals.org/doi/full/10.1161/01.ATV.0000280571.28102.d4?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -