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Improvement of microcirculation and healing of venous hypertension and ulcers with Crystacide: evaluation with a microcirculatory model, including free radicals, laser doppler flux, and PO2/PCO2 measurements.
Angiology. 2007 Jun-Jul; 58(3):323-8.A

Abstract

In 32 patients with chronic venous insufficiency and venous hypertension associated with ulcerations, the effects of the local application of a hydrogen peroxide cream (Crystacide) applied onto the skin was evaluated using a complex, proportional, microcirculatory model to assess and quantify venous microangiopathy after local treatment. A comparative group treated without Crystacide was included. Laser Doppler flowmetry was used to assess skin perfusion (flux and venoarteriolar response) in association with transcutaneous PO2 and PCO2 measurements. Local plasma free radicals were evaluated in the area surrounding the venous ulcer using the D-Roms test. Crystacide was applied around and on the ulcer for 10 days. Crystacide was more effective than the control treatments. PO2 was increased (improved, P < .05), and plasma free radicals, PCO2, and laser Doppler flowmetry were decreased (improving toward normal values, P < .05). Also, the ulcerated area was significantly smaller at 10 days in the Crystacide group in comparison with controls (P < .05). In the proportional microcirculatory model, all parameters indicated an important level of improvement significantly larger than in controls. In conclusion, in chronic venous insufficiency and venous ulcerations, local treatment with Crystacide (10 days) improves the microcirculation and decreases skin free radicals, thus improving healing.

Authors+Show Affiliations

Irvine Vascular Laboratory and Physiology, Department of Biomedical Sciences, Chieti University, San Valentino Vascular Screening Project, PE, Italy. cardres@abol.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

17626987

Citation

Belcaro, Gianni, et al. "Improvement of Microcirculation and Healing of Venous Hypertension and Ulcers With Crystacide: Evaluation With a Microcirculatory Model, Including Free Radicals, Laser Doppler Flux, and PO2/PCO2 Measurements." Angiology, vol. 58, no. 3, 2007, pp. 323-8.
Belcaro G, Cesarone MR, Errichi BM, et al. Improvement of microcirculation and healing of venous hypertension and ulcers with Crystacide: evaluation with a microcirculatory model, including free radicals, laser doppler flux, and PO2/PCO2 measurements. Angiology. 2007;58(3):323-8.
Belcaro, G., Cesarone, M. R., Errichi, B. M., Di Renzo, A., Errichi, S., Ricci, A., Gizzi, G., Dugall, M., Cacchio, M., Ruffini, I., Fano, F., Vinciguerra, G., & Grossi, M. G. (2007). Improvement of microcirculation and healing of venous hypertension and ulcers with Crystacide: evaluation with a microcirculatory model, including free radicals, laser doppler flux, and PO2/PCO2 measurements. Angiology, 58(3), 323-8.
Belcaro G, et al. Improvement of Microcirculation and Healing of Venous Hypertension and Ulcers With Crystacide: Evaluation With a Microcirculatory Model, Including Free Radicals, Laser Doppler Flux, and PO2/PCO2 Measurements. Angiology. 2007 Jun-Jul;58(3):323-8. PubMed PMID: 17626987.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improvement of microcirculation and healing of venous hypertension and ulcers with Crystacide: evaluation with a microcirculatory model, including free radicals, laser doppler flux, and PO2/PCO2 measurements. AU - Belcaro,Gianni, AU - Cesarone,Maria Rosaria, AU - Errichi,Bruno M, AU - Di Renzo,Andrea, AU - Errichi,Silvia, AU - Ricci,Andrea, AU - Gizzi,Giuseppe, AU - Dugall,Mark, AU - Cacchio,Marisa, AU - Ruffini,Irma, AU - Fano,Filiberto, AU - Vinciguerra,Giulia, AU - Grossi,Maria Giovanna, PY - 2007/7/14/pubmed PY - 2007/8/3/medline PY - 2007/7/14/entrez SP - 323 EP - 8 JF - Angiology JO - Angiology VL - 58 IS - 3 N2 - In 32 patients with chronic venous insufficiency and venous hypertension associated with ulcerations, the effects of the local application of a hydrogen peroxide cream (Crystacide) applied onto the skin was evaluated using a complex, proportional, microcirculatory model to assess and quantify venous microangiopathy after local treatment. A comparative group treated without Crystacide was included. Laser Doppler flowmetry was used to assess skin perfusion (flux and venoarteriolar response) in association with transcutaneous PO2 and PCO2 measurements. Local plasma free radicals were evaluated in the area surrounding the venous ulcer using the D-Roms test. Crystacide was applied around and on the ulcer for 10 days. Crystacide was more effective than the control treatments. PO2 was increased (improved, P < .05), and plasma free radicals, PCO2, and laser Doppler flowmetry were decreased (improving toward normal values, P < .05). Also, the ulcerated area was significantly smaller at 10 days in the Crystacide group in comparison with controls (P < .05). In the proportional microcirculatory model, all parameters indicated an important level of improvement significantly larger than in controls. In conclusion, in chronic venous insufficiency and venous ulcerations, local treatment with Crystacide (10 days) improves the microcirculation and decreases skin free radicals, thus improving healing. SN - 0003-3197 UR - https://www.unboundmedicine.com/medline/citation/17626987/Improvement_of_microcirculation_and_healing_of_venous_hypertension_and_ulcers_with_Crystacide:_evaluation_with_a_microcirculatory_model_including_free_radicals_laser_doppler_flux_and_PO2/PCO2_measurements_ L2 - https://journals.sagepub.com/doi/10.1177/0003319707301450?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -