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Body mass index and mortality among older breast cancer survivors in the Study of Osteoporotic Fractures.
Cancer Epidemiol Biomarkers Prev. 2007 Jul; 16(7):1468-73.CE

Abstract

BACKGROUND

Breast cancer survival is inversely related to body mass index (BMI), but previous studies have not included large numbers of older women. This study investigated the association between BMI and mortality after breast cancer diagnosis in a cohort of older Caucasian women enrolled in the Study of Osteoporotic Fractures.

METHODS

All women were age >or=65 at study entry (N = 533). Cox proportional hazards regression analysis was used to determine the effect of BMI as a continuous variable on risk of all-cause, cardiovascular, any cancer, and breast cancer mortality. Interaction terms were included to evaluate effect modification by age at diagnosis.

RESULTS

Mean age at diagnosis was 78.0 years (SD 5.7) with an average of 8.1 years (SD 4.4) of follow-up after diagnosis. There were 206 deaths during follow-up. The effect of BMI on mortality depended on age (P(interaction) = 0.02). At age 65, the risk of mortality was 1.4 times higher for a BMI of 27.3 kg/m(2) [95% confidence interval (95% CI), 1.03-2.01] and 2.4 times higher for a BMI of 34.0 kg/m2 (95% CI, 1.07-5.45) compared with women with a BMI of 22.6 kg/m2. At age 85, risk of death was lower for a BMI of 27.3 kg/m2 (hazard ratio, 0.81; 95% CI, 0.65-1.01) or a BMI of 34.0 kg/m2 (hazard ratio, 0.61; 95% CI, 0.36-1.02) compared with a BMI of 22.6 kg/m2. Similar results were observed for any cancer and breast cancer mortality. BMI was not associated with cardiovascular mortality.

CONCLUSIONS

In this population of older women, the effect of increased BMI on risk of mortality after breast cancer varied by age. These results differ from those observed among populations of younger postmenopausal breast cancer survivors.

Authors+Show Affiliations

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 516A Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, USA. kwr2@pitt.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17627012

Citation

Reeves, Katherine W., et al. "Body Mass Index and Mortality Among Older Breast Cancer Survivors in the Study of Osteoporotic Fractures." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 16, no. 7, 2007, pp. 1468-73.
Reeves KW, Faulkner K, Modugno F, et al. Body mass index and mortality among older breast cancer survivors in the Study of Osteoporotic Fractures. Cancer Epidemiol Biomarkers Prev. 2007;16(7):1468-73.
Reeves, K. W., Faulkner, K., Modugno, F., Hillier, T. A., Bauer, D. C., Ensrud, K. E., & Cauley, J. A. (2007). Body mass index and mortality among older breast cancer survivors in the Study of Osteoporotic Fractures. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 16(7), 1468-73.
Reeves KW, et al. Body Mass Index and Mortality Among Older Breast Cancer Survivors in the Study of Osteoporotic Fractures. Cancer Epidemiol Biomarkers Prev. 2007;16(7):1468-73. PubMed PMID: 17627012.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body mass index and mortality among older breast cancer survivors in the Study of Osteoporotic Fractures. AU - Reeves,Katherine W, AU - Faulkner,Kimberly, AU - Modugno,Francesmary, AU - Hillier,Teresa A, AU - Bauer,Douglas C, AU - Ensrud,Kristine E, AU - Cauley,Jane A, AU - ,, PY - 2007/7/14/pubmed PY - 2007/8/29/medline PY - 2007/7/14/entrez SP - 1468 EP - 73 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 16 IS - 7 N2 - BACKGROUND: Breast cancer survival is inversely related to body mass index (BMI), but previous studies have not included large numbers of older women. This study investigated the association between BMI and mortality after breast cancer diagnosis in a cohort of older Caucasian women enrolled in the Study of Osteoporotic Fractures. METHODS: All women were age >or=65 at study entry (N = 533). Cox proportional hazards regression analysis was used to determine the effect of BMI as a continuous variable on risk of all-cause, cardiovascular, any cancer, and breast cancer mortality. Interaction terms were included to evaluate effect modification by age at diagnosis. RESULTS: Mean age at diagnosis was 78.0 years (SD 5.7) with an average of 8.1 years (SD 4.4) of follow-up after diagnosis. There were 206 deaths during follow-up. The effect of BMI on mortality depended on age (P(interaction) = 0.02). At age 65, the risk of mortality was 1.4 times higher for a BMI of 27.3 kg/m(2) [95% confidence interval (95% CI), 1.03-2.01] and 2.4 times higher for a BMI of 34.0 kg/m2 (95% CI, 1.07-5.45) compared with women with a BMI of 22.6 kg/m2. At age 85, risk of death was lower for a BMI of 27.3 kg/m2 (hazard ratio, 0.81; 95% CI, 0.65-1.01) or a BMI of 34.0 kg/m2 (hazard ratio, 0.61; 95% CI, 0.36-1.02) compared with a BMI of 22.6 kg/m2. Similar results were observed for any cancer and breast cancer mortality. BMI was not associated with cardiovascular mortality. CONCLUSIONS: In this population of older women, the effect of increased BMI on risk of mortality after breast cancer varied by age. These results differ from those observed among populations of younger postmenopausal breast cancer survivors. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/17627012/Body_mass_index_and_mortality_among_older_breast_cancer_survivors_in_the_Study_of_Osteoporotic_Fractures_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=17627012 DB - PRIME DP - Unbound Medicine ER -