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Blockade of the nociceptin/orphanin FQ/NOP receptor system in the rat ventrolateral periaqueductal gray potentiates DAMGO analgesia.
Peptides. 2007 Jul; 28(7):1441-6.P

Abstract

Nociceptin/orphanin FQ (N/OFQ) and its receptor (NOP) are involved in various biological functions including pain. High density of NOP receptor has been found in the ventrolateral periaqueductal gray (vlPAG), the main output pathway involved in descending pain-control system. The aim of our work was to evaluate the involvement of the N/OFQ/NOP system in the modulation of MOP analgesia in the rat vlPAG using UFP-101, a selective NOP antagonist. N/OFQ significantly blocked DAMGO (a selective MOP agonist) analgesia, while UFP-101 enhanced the effect of the opioid given at a subanalgesic dose. These results confirm our hypothesis of an antiopioid role for N/OFQ in the vlPAG.

Authors+Show Affiliations

Department of Pharmaceutical Sciences-Pharmacology Section, University of Catania, v.le A. Doria 6, 95125 Catania, Italy. scotog@unict.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17628212

Citation

Scoto, Giovanna M., et al. "Blockade of the Nociceptin/orphanin FQ/NOP Receptor System in the Rat Ventrolateral Periaqueductal Gray Potentiates DAMGO Analgesia." Peptides, vol. 28, no. 7, 2007, pp. 1441-6.
Scoto GM, Aricò G, Ronsisvalle S, et al. Blockade of the nociceptin/orphanin FQ/NOP receptor system in the rat ventrolateral periaqueductal gray potentiates DAMGO analgesia. Peptides. 2007;28(7):1441-6.
Scoto, G. M., Aricò, G., Ronsisvalle, S., & Parenti, C. (2007). Blockade of the nociceptin/orphanin FQ/NOP receptor system in the rat ventrolateral periaqueductal gray potentiates DAMGO analgesia. Peptides, 28(7), 1441-6.
Scoto GM, et al. Blockade of the Nociceptin/orphanin FQ/NOP Receptor System in the Rat Ventrolateral Periaqueductal Gray Potentiates DAMGO Analgesia. Peptides. 2007;28(7):1441-6. PubMed PMID: 17628212.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blockade of the nociceptin/orphanin FQ/NOP receptor system in the rat ventrolateral periaqueductal gray potentiates DAMGO analgesia. AU - Scoto,Giovanna M, AU - Aricò,Giuseppina, AU - Ronsisvalle,Simone, AU - Parenti,Carmela, Y1 - 2007/06/14/ PY - 2007/04/03/received PY - 2007/05/30/revised PY - 2007/05/30/accepted PY - 2007/7/14/pubmed PY - 2007/12/6/medline PY - 2007/7/14/entrez SP - 1441 EP - 6 JF - Peptides JO - Peptides VL - 28 IS - 7 N2 - Nociceptin/orphanin FQ (N/OFQ) and its receptor (NOP) are involved in various biological functions including pain. High density of NOP receptor has been found in the ventrolateral periaqueductal gray (vlPAG), the main output pathway involved in descending pain-control system. The aim of our work was to evaluate the involvement of the N/OFQ/NOP system in the modulation of MOP analgesia in the rat vlPAG using UFP-101, a selective NOP antagonist. N/OFQ significantly blocked DAMGO (a selective MOP agonist) analgesia, while UFP-101 enhanced the effect of the opioid given at a subanalgesic dose. These results confirm our hypothesis of an antiopioid role for N/OFQ in the vlPAG. SN - 0196-9781 UR - https://www.unboundmedicine.com/medline/citation/17628212/Blockade_of_the_nociceptin/orphanin_FQ/NOP_receptor_system_in_the_rat_ventrolateral_periaqueductal_gray_potentiates_DAMGO_analgesia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0196-9781(07)00195-7 DB - PRIME DP - Unbound Medicine ER -