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Early premorbid adjustment as a moderator of the impact of duration of untreated psychosis.
Schizophr Res. 2007 Sep; 95(1-3):111-4.SR

Abstract

OBJECTIVES

Shorter duration of untreated psychosis (DUP) is often correlated with a poorer response to treatment. In this paper we test the hypothesis that the importance of DUP is moderated by early premorbid adjustment.

METHOD

Three year prospective data were collected for 154 first episode patients. DUP, premorbid adjustment and symptoms were assessed at time of presentation for treatment and symptoms were reassessed after three years of treatment.

RESULTS

DUP was correlated with level of symptoms at three years only for patients with better premorbid adjustment in childhood and early adolescence.

CONCLUSIONS

These results suggest that DUP may have more of an impact on treatment response for those with a less pernicious, more reversible form of illness.

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Authors+Show Affiliations

Norman RM
University of Western Ontario and Prevention and Early Intervention Program for Psychoses, WMCH Building, 392 South Street, London, Ontario, Canada N6A 4G5. rnorman@uwo.ca
Malla AK
No affiliation info available
Manchanda R
No affiliation info available

MeSH

AchievementAdaptation, PsychologicalAdultAntipsychotic AgentsDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleProspective StudiesPsychiatric Status Rating ScalesPsychotic DisordersRisk FactorsSchizophreniaSchizophrenic PsychologySocial AdjustmentTime FactorsTreatment Outcome

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17628442

Citation

Norman, Ross M G., et al. "Early Premorbid Adjustment as a Moderator of the Impact of Duration of Untreated Psychosis." Schizophrenia Research, vol. 95, no. 1-3, 2007, pp. 111-4.
Norman RM, Malla AK, Manchanda R. Early premorbid adjustment as a moderator of the impact of duration of untreated psychosis. Schizophr Res. 2007;95(1-3):111-4.
Norman, R. M., Malla, A. K., & Manchanda, R. (2007). Early premorbid adjustment as a moderator of the impact of duration of untreated psychosis. Schizophrenia Research, 95(1-3), 111-4.
Norman RM, Malla AK, Manchanda R. Early Premorbid Adjustment as a Moderator of the Impact of Duration of Untreated Psychosis. Schizophr Res. 2007;95(1-3):111-4. PubMed PMID: 17628442.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early premorbid adjustment as a moderator of the impact of duration of untreated psychosis. AU - Norman,Ross M G, AU - Malla,Ashok K, AU - Manchanda,Rahul, Y1 - 2007/07/12/ PY - 2007/03/05/received PY - 2007/06/07/revised PY - 2007/06/12/accepted PY - 2007/7/14/pubmed PY - 2007/10/25/medline PY - 2007/7/14/entrez SP - 111 EP - 4 JF - Schizophrenia research JO - Schizophr Res VL - 95 IS - 1-3 N2 - OBJECTIVES: Shorter duration of untreated psychosis (DUP) is often correlated with a poorer response to treatment. In this paper we test the hypothesis that the importance of DUP is moderated by early premorbid adjustment. METHOD: Three year prospective data were collected for 154 first episode patients. DUP, premorbid adjustment and symptoms were assessed at time of presentation for treatment and symptoms were reassessed after three years of treatment. RESULTS: DUP was correlated with level of symptoms at three years only for patients with better premorbid adjustment in childhood and early adolescence. CONCLUSIONS: These results suggest that DUP may have more of an impact on treatment response for those with a less pernicious, more reversible form of illness. SN - 0920-9964 UR - https://www.unboundmedicine.com/medline/citation/17628442/Early_premorbid_adjustment_as_a_moderator_of_the_impact_of_duration_of_untreated_psychosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920-9964(07)00262-9 DB - PRIME DP - Unbound Medicine ER -