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Histone acetylation and methylation in the signaling of steroid hormone receptors.
Cell Mol Biol (Noisy-le-grand). 2007; 53 Suppl:OL930-42.CM

Abstract

Molecular changes associated with malignancy are extremely complex. Early epigenetic events occurring in the common tumor types such as breast or prostate cancer might determine the subsequent genetic changes leading to tumor development and progression. Covalent modifications of histones play a major role as determiners of epigenetic information and are important in the regulation of gene expression. Acetylation generally correlates with transcriptional activation, while methylation can signal either activation or repression. However, little is known about the interplay of different epigenetic events. Steroid hormones regulate many cellular processes through signal transduction pathways that result in a variety of post-translational modifications. Such modifications can be triggered by steroid hormones in cooperation with coactivators(p160 family proteins, CBP, p300, p/CAF) and/or corepressors (N-Cor, SMRT, TZF). There is still much to learn about their regulation and the molecular and physiological consequences of these modifications.

Authors+Show Affiliations

Laboratory of Molecular Pathology and Institute of Pathology, Faculty of Medicine, Palacky University, Hnevotinska 3, Olomouc, Czech Republic. trtkova@post.czNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17628895

Citation

Trtková, K, et al. "Histone Acetylation and Methylation in the Signaling of Steroid Hormone Receptors." Cellular and Molecular Biology (Noisy-le-Grand, France), vol. 53 Suppl, 2007, pp. OL930-42.
Trtková K, Bouchal J, Kolàr Z. Histone acetylation and methylation in the signaling of steroid hormone receptors. Cell Mol Biol (Noisy-le-grand). 2007;53 Suppl:OL930-42.
Trtková, K., Bouchal, J., & Kolàr, Z. (2007). Histone acetylation and methylation in the signaling of steroid hormone receptors. Cellular and Molecular Biology (Noisy-le-Grand, France), 53 Suppl, OL930-42.
Trtková K, Bouchal J, Kolàr Z. Histone Acetylation and Methylation in the Signaling of Steroid Hormone Receptors. Cell Mol Biol (Noisy-le-grand). 2007;53 Suppl:OL930-42. PubMed PMID: 17628895.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histone acetylation and methylation in the signaling of steroid hormone receptors. AU - Trtková,K, AU - Bouchal,J, AU - Kolàr,Z, PY - 2007/7/17/pubmed PY - 2009/6/2/medline PY - 2007/7/17/entrez SP - OL930 EP - 42 JF - Cellular and molecular biology (Noisy-le-Grand, France) JO - Cell Mol Biol (Noisy-le-grand) VL - 53 Suppl N2 - Molecular changes associated with malignancy are extremely complex. Early epigenetic events occurring in the common tumor types such as breast or prostate cancer might determine the subsequent genetic changes leading to tumor development and progression. Covalent modifications of histones play a major role as determiners of epigenetic information and are important in the regulation of gene expression. Acetylation generally correlates with transcriptional activation, while methylation can signal either activation or repression. However, little is known about the interplay of different epigenetic events. Steroid hormones regulate many cellular processes through signal transduction pathways that result in a variety of post-translational modifications. Such modifications can be triggered by steroid hormones in cooperation with coactivators(p160 family proteins, CBP, p300, p/CAF) and/or corepressors (N-Cor, SMRT, TZF). There is still much to learn about their regulation and the molecular and physiological consequences of these modifications. SN - 1165-158X UR - https://www.unboundmedicine.com/medline/citation/17628895/Histone_acetylation_and_methylation_in_the_signaling_of_steroid_hormone_receptors_ L2 - https://antibodies.cancer.gov/detail/CPTC-NCOR1-1 DB - PRIME DP - Unbound Medicine ER -