Jiménez-Romero, Carlos, et al. "Hydroxyalkenylresorcinols From Stylogyne Turbacensis." Journal of Natural Products, vol. 70, no. 8, 2007, pp. 1249-52.
Jiménez-Romero C, Torres-Mendoza D, Ureña González LD, et al. Hydroxyalkenylresorcinols from Stylogyne turbacensis. J Nat Prod. 2007;70(8):1249-52.
Jiménez-Romero, C., Torres-Mendoza, D., Ureña González, L. D., Ortega-Barría, E., McPhail, K. L., Gerwick, W. H., & Cubilla-Rios, L. (2007). Hydroxyalkenylresorcinols from Stylogyne turbacensis. Journal of Natural Products, 70(8), 1249-52.
Jiménez-Romero C, et al. Hydroxyalkenylresorcinols From Stylogyne Turbacensis. J Nat Prod. 2007;70(8):1249-52. PubMed PMID: 17629327.
TY - JOUR
T1 - Hydroxyalkenylresorcinols from Stylogyne turbacensis.
AU - Jiménez-Romero,Carlos,
AU - Torres-Mendoza,Daniel,
AU - Ureña González,Luis David,
AU - Ortega-Barría,Eduardo,
AU - McPhail,Kerry L,
AU - Gerwick,William H,
AU - Cubilla-Rios,Luis,
Y1 - 2007/07/13/
PY - 2007/7/17/pubmed
PY - 2007/10/5/medline
PY - 2007/7/17/entrez
SP - 1249
EP - 52
JF - Journal of natural products
JO - J Nat Prod
VL - 70
IS - 8
N2 - Two new compounds, 5-(11'(S)-hydroxy-8'-heptadecenyl)resorcinol (3) and 5-(12'(S)-hydroxy-8',14'-heptadecadienyl)resorcinol (4), were isolated from the leaves of Stylogyne turbacensis together with the known analogue metabolites 1 and 2. Compounds 3 and 4 showed the strongest activity in the leishmania assay, 7 and 3 microM, respectively, while compounds 1, 2, and 4 showed moderate activity against a drug-resistant strain of Trypanosoma cruzi with IC(50) values of 30, 25, and 22 microM, respectively. Additional testing in MCF-7 and NCI-H460 was performed for compounds 3 and 4. The structures of compounds 1-4 were elucidated using NMR, MS, and other spectroscopic data. The absolute stereochemistry of compounds 3 and 4 was also investigated using the Mosher ester approach. Peracetylated derivatives of these four metabolites were produced and their activities determined in the Trypanosoma cruzi assay.
SN - 0163-3864
UR - https://www.unboundmedicine.com/medline/citation/17629327/Hydroxyalkenylresorcinols_from_Stylogyne_turbacensis_
L2 - https://doi.org/10.1021/np070081d
DB - PRIME
DP - Unbound Medicine