Tags

Type your tag names separated by a space and hit enter

Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study.

Abstract

BACKGROUND

Low dietary intake of the essential nutrient choline and its metabolite betaine may increase atherogenesis both through effects on homocysteine methylation pathways as well as through choline's antioxidants properties. Nutrient values for many common foods for choline and betaine have recently become available in the U.S. nutrient composition database. Our objective was to assess the association of dietary intake of choline and betaine with incident coronary heart disease (CHD), adjusting for dietary intake measurement error.

METHODS

We conducted a prospective investigation of the relation between usual intake of choline and betaine with the risk of CHD in 14,430 middle-aged men and women of the biethnic Atherosclerosis Risk in Communities study. A semi-quantitative food frequency questionnaire was used to assess nutrient intake. Proportional hazard regression models were used to calculate the risk of incident CHD. A regression calibration method was used to adjust for measurement error.

RESULTS

During an average 14 years of follow-up (1987-2002), 1,072 incident CHD events were documented. Compared with the lowest quartile of intake, incident CHD risk was slightly and non-significantly higher in the highest quartile of choline and choline plus betaine, HR = 1.22 (0.91, 1.64) and HR = 1.14 (0.85, 1.53), controlling for age, sex, education, total energy intake, dietary intakes of folate, methionine and vitamin B6. No association was found between dietary choline intake and incident CHD when correcting for measurement error.

CONCLUSION

Higher intakes of choline and betaine were not protective for incident CHD. Similar investigations in other populations are of interest.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA. aurelian@email.unc.edu

    , , ,

    Source

    BMC cardiovascular disorders 7: 2007 Jul 13 pg 20

    MeSH

    Atherosclerosis
    Betaine
    Choline
    Coronary Disease
    Diet
    Female
    Follow-Up Studies
    Humans
    Incidence
    Male
    Middle Aged
    Nutrition Assessment
    Nutrition Surveys
    Proportional Hazards Models
    Prospective Studies
    Risk Assessment
    Risk Factors
    Surveys and Questionnaires
    Time Factors
    United States

    Pub Type(s)

    Comparative Study
    Journal Article
    Multicenter Study
    Research Support, N.I.H., Extramural
    Research Support, U.S. Gov't, Non-P.H.S.

    Language

    eng

    PubMed ID

    17629908

    Citation

    Bidulescu, Aurelian, et al. "Usual Choline and Betaine Dietary Intake and Incident Coronary Heart Disease: the Atherosclerosis Risk in Communities (ARIC) Study." BMC Cardiovascular Disorders, vol. 7, 2007, p. 20.
    Bidulescu A, Chambless LE, Siega-Riz AM, et al. Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study. BMC Cardiovasc Disord. 2007;7:20.
    Bidulescu, A., Chambless, L. E., Siega-Riz, A. M., Zeisel, S. H., & Heiss, G. (2007). Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study. BMC Cardiovascular Disorders, 7, p. 20.
    Bidulescu A, et al. Usual Choline and Betaine Dietary Intake and Incident Coronary Heart Disease: the Atherosclerosis Risk in Communities (ARIC) Study. BMC Cardiovasc Disord. 2007 Jul 13;7:20. PubMed PMID: 17629908.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study. AU - Bidulescu,Aurelian, AU - Chambless,Lloyd E, AU - Siega-Riz,Anna Maria, AU - Zeisel,Steven H, AU - Heiss,Gerardo, Y1 - 2007/07/13/ PY - 2006/11/22/received PY - 2007/07/13/accepted PY - 2007/7/17/pubmed PY - 2007/8/19/medline PY - 2007/7/17/entrez SP - 20 EP - 20 JF - BMC cardiovascular disorders JO - BMC Cardiovasc Disord VL - 7 N2 - BACKGROUND: Low dietary intake of the essential nutrient choline and its metabolite betaine may increase atherogenesis both through effects on homocysteine methylation pathways as well as through choline's antioxidants properties. Nutrient values for many common foods for choline and betaine have recently become available in the U.S. nutrient composition database. Our objective was to assess the association of dietary intake of choline and betaine with incident coronary heart disease (CHD), adjusting for dietary intake measurement error. METHODS: We conducted a prospective investigation of the relation between usual intake of choline and betaine with the risk of CHD in 14,430 middle-aged men and women of the biethnic Atherosclerosis Risk in Communities study. A semi-quantitative food frequency questionnaire was used to assess nutrient intake. Proportional hazard regression models were used to calculate the risk of incident CHD. A regression calibration method was used to adjust for measurement error. RESULTS: During an average 14 years of follow-up (1987-2002), 1,072 incident CHD events were documented. Compared with the lowest quartile of intake, incident CHD risk was slightly and non-significantly higher in the highest quartile of choline and choline plus betaine, HR = 1.22 (0.91, 1.64) and HR = 1.14 (0.85, 1.53), controlling for age, sex, education, total energy intake, dietary intakes of folate, methionine and vitamin B6. No association was found between dietary choline intake and incident CHD when correcting for measurement error. CONCLUSION: Higher intakes of choline and betaine were not protective for incident CHD. Similar investigations in other populations are of interest. SN - 1471-2261 UR - https://www.unboundmedicine.com/medline/citation/17629908/Usual_choline_and_betaine_dietary_intake_and_incident_coronary_heart_disease:_the_Atherosclerosis_Risk_in_Communities__ARIC__study_ L2 - https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/1471-2261-7-20 DB - PRIME DP - Unbound Medicine ER -