Tags

Type your tag names separated by a space and hit enter

A sulfated fucan from the brown alga Laminaria cichorioides has mainly heparin cofactor II-dependent anticoagulant activity.
Carbohydr Res. 2007 Nov 05; 342(15):2326-30.CR

Abstract

The major acidic polysaccharide from the brown alga Laminaria cichorioides is a complex and heterogeneous sulfated fucan. Its preponderant structure is a 2,3-disulfated, 4-linked alpha-fucose unit. The purified polysaccharide has a potent anticoagulant activity, as estimated by APTT assay (approximately 40 IU/mg), which is mainly mediated by thrombin inhibition by heparin cofactor II. It also accelerates thrombin and factor Xa inhibition by antithrombin but at a lower potency. Sulfated fucan from L. cichorioides is a promising anticoagulant polysaccharide and a possible alternative for an antithrombotic compound due to its preferential heparin cofactor II-dependent activity.

Links

Publisher Full Text

Authors+Show Affiliations

Yoon SJ
Laboratório de Tecido Conjuntivo, Hospital Universitário Clementino Fraga Filho and Programa de Glicobiologia, Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Caixa Postal 68041, Rio de Janeiro, RJ 21941-590, Brazil.
Pyun YR
No affiliation info available
Hwang JK
No affiliation info available
Mourão PA
No affiliation info available

MeSH

AnimalsAnticoagulantsBlood Coagulation TestsChromatography, Ion ExchangeDose-Response Relationship, DrugFactor XaHeparinHeparin Cofactor IIHumansLaminariaMagnetic Resonance SpectroscopyPhaeophytaPolysaccharidesSubcellular FractionsThrombin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17631282

Citation

Yoon, Seon-Joo, et al. "A Sulfated Fucan From the Brown Alga Laminaria Cichorioides Has Mainly Heparin Cofactor II-dependent Anticoagulant Activity." Carbohydrate Research, vol. 342, no. 15, 2007, pp. 2326-30.
Yoon SJ, Pyun YR, Hwang JK, et al. A sulfated fucan from the brown alga Laminaria cichorioides has mainly heparin cofactor II-dependent anticoagulant activity. Carbohydr Res. 2007;342(15):2326-30.
Yoon, S. J., Pyun, Y. R., Hwang, J. K., & Mourão, P. A. (2007). A sulfated fucan from the brown alga Laminaria cichorioides has mainly heparin cofactor II-dependent anticoagulant activity. Carbohydrate Research, 342(15), 2326-30.
Yoon SJ, et al. A Sulfated Fucan From the Brown Alga Laminaria Cichorioides Has Mainly Heparin Cofactor II-dependent Anticoagulant Activity. Carbohydr Res. 2007 Nov 5;342(15):2326-30. PubMed PMID: 17631282.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A sulfated fucan from the brown alga Laminaria cichorioides has mainly heparin cofactor II-dependent anticoagulant activity. AU - Yoon,Seon-Joo, AU - Pyun,Yu-Ryang, AU - Hwang,Jae-Kwan, AU - Mourão,Paulo A S, Y1 - 2007/06/28/ PY - 2007/01/23/received PY - 2007/06/05/revised PY - 2007/06/18/accepted PY - 2007/7/17/pubmed PY - 2007/12/14/medline PY - 2007/7/17/entrez SP - 2326 EP - 30 JF - Carbohydrate research JO - Carbohydr Res VL - 342 IS - 15 N2 - The major acidic polysaccharide from the brown alga Laminaria cichorioides is a complex and heterogeneous sulfated fucan. Its preponderant structure is a 2,3-disulfated, 4-linked alpha-fucose unit. The purified polysaccharide has a potent anticoagulant activity, as estimated by APTT assay (approximately 40 IU/mg), which is mainly mediated by thrombin inhibition by heparin cofactor II. It also accelerates thrombin and factor Xa inhibition by antithrombin but at a lower potency. Sulfated fucan from L. cichorioides is a promising anticoagulant polysaccharide and a possible alternative for an antithrombotic compound due to its preferential heparin cofactor II-dependent activity. SN - 0008-6215 UR - https://www.unboundmedicine.com/medline/citation/17631282/A_sulfated_fucan_from_the_brown_alga_Laminaria_cichorioides_has_mainly_heparin_cofactor_II_dependent_anticoagulant_activity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0008-6215(07)00291-1 DB - PRIME DP - Unbound Medicine ER -