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Jingzhaotoxin-XII, a gating modifier specific for Kv4.1 channels.
Toxicon. 2007 Oct; 50(5):646-52.T

Abstract

Jingzhaotoxin-XII (JZTX-XII), a 29-residue polypeptide, was purified from the venom of the Chinese tarantula Chilobrachys jingzhao. Electrophysiological recordings carried out in Xenopus laevis oocytes showed that JZTX-XII is specific for Kv4.1 channels, with the IC50 value of 0.363 microM. It interacts with the channels by modifying the gating behavior. JZTX-XII shares 80% sequence identity with phrixotoxin1, a potent inhibitor for Kv4.2 and Kv4.3 channels. Structure analysis indicates that the difference of the charge distribution in the interactive surface perhaps influences the specific pharmacology of the toxins. JZTX-XII should be a valuable tool for the investigation of the Kv4.1 channels.

Authors+Show Affiliations

Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education, Life Science College, Hunan Normal University, Changsha 410081, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17631373

Citation

Yuan, Chunhua, et al. "Jingzhaotoxin-XII, a Gating Modifier Specific for Kv4.1 Channels." Toxicon : Official Journal of the International Society On Toxinology, vol. 50, no. 5, 2007, pp. 646-52.
Yuan C, Liao Z, Zeng X, et al. Jingzhaotoxin-XII, a gating modifier specific for Kv4.1 channels. Toxicon. 2007;50(5):646-52.
Yuan, C., Liao, Z., Zeng, X., Dai, L., Kuang, F., & Liang, S. (2007). Jingzhaotoxin-XII, a gating modifier specific for Kv4.1 channels. Toxicon : Official Journal of the International Society On Toxinology, 50(5), 646-52.
Yuan C, et al. Jingzhaotoxin-XII, a Gating Modifier Specific for Kv4.1 Channels. Toxicon. 2007;50(5):646-52. PubMed PMID: 17631373.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Jingzhaotoxin-XII, a gating modifier specific for Kv4.1 channels. AU - Yuan,Chunhua, AU - Liao,Zhi, AU - Zeng,Xiongzhi, AU - Dai,Longjun, AU - Kuang,Fang, AU - Liang,Songping, Y1 - 2007/06/03/ PY - 2007/02/15/received PY - 2007/05/15/revised PY - 2007/05/29/accepted PY - 2007/7/17/pubmed PY - 2007/12/12/medline PY - 2007/7/17/entrez SP - 646 EP - 52 JF - Toxicon : official journal of the International Society on Toxinology JO - Toxicon VL - 50 IS - 5 N2 - Jingzhaotoxin-XII (JZTX-XII), a 29-residue polypeptide, was purified from the venom of the Chinese tarantula Chilobrachys jingzhao. Electrophysiological recordings carried out in Xenopus laevis oocytes showed that JZTX-XII is specific for Kv4.1 channels, with the IC50 value of 0.363 microM. It interacts with the channels by modifying the gating behavior. JZTX-XII shares 80% sequence identity with phrixotoxin1, a potent inhibitor for Kv4.2 and Kv4.3 channels. Structure analysis indicates that the difference of the charge distribution in the interactive surface perhaps influences the specific pharmacology of the toxins. JZTX-XII should be a valuable tool for the investigation of the Kv4.1 channels. SN - 0041-0101 UR - https://www.unboundmedicine.com/medline/citation/17631373/Jingzhaotoxin_XII_a_gating_modifier_specific_for_Kv4_1_channels_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-0101(07)00205-X DB - PRIME DP - Unbound Medicine ER -