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Jingzhaotoxin-XII, a gating modifier specific for Kv4.1 channels.
Toxicon. 2007 Oct; 50(5):646-52.T

Abstract

Jingzhaotoxin-XII (JZTX-XII), a 29-residue polypeptide, was purified from the venom of the Chinese tarantula Chilobrachys jingzhao. Electrophysiological recordings carried out in Xenopus laevis oocytes showed that JZTX-XII is specific for Kv4.1 channels, with the IC50 value of 0.363 microM. It interacts with the channels by modifying the gating behavior. JZTX-XII shares 80% sequence identity with phrixotoxin1, a potent inhibitor for Kv4.2 and Kv4.3 channels. Structure analysis indicates that the difference of the charge distribution in the interactive surface perhaps influences the specific pharmacology of the toxins. JZTX-XII should be a valuable tool for the investigation of the Kv4.1 channels.

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Authors+Show Affiliations

Yuan C
Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education, Life Science College, Hunan Normal University, Changsha 410081, PR China.
Liao Z
No affiliation info available
Zeng X
No affiliation info available
Dai L
No affiliation info available
Kuang F
No affiliation info available
Liang S
No affiliation info available

MeSH

AnimalsDose-Response Relationship, DrugIon Channel GatingMolecular StructureOocytesPatch-Clamp TechniquesPeptidesPotassium Channel BlockersShab Potassium ChannelsShal Potassium ChannelsSpider VenomsStructure-Activity RelationshipXenopus laevis

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17631373

Citation

Yuan, Chunhua, et al. "Jingzhaotoxin-XII, a Gating Modifier Specific for Kv4.1 Channels." Toxicon : Official Journal of the International Society On Toxinology, vol. 50, no. 5, 2007, pp. 646-52.
Yuan C, Liao Z, Zeng X, et al. Jingzhaotoxin-XII, a gating modifier specific for Kv4.1 channels. Toxicon. 2007;50(5):646-52.
Yuan, C., Liao, Z., Zeng, X., Dai, L., Kuang, F., & Liang, S. (2007). Jingzhaotoxin-XII, a gating modifier specific for Kv4.1 channels. Toxicon : Official Journal of the International Society On Toxinology, 50(5), 646-52.
Yuan C, et al. Jingzhaotoxin-XII, a Gating Modifier Specific for Kv4.1 Channels. Toxicon. 2007;50(5):646-52. PubMed PMID: 17631373.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Jingzhaotoxin-XII, a gating modifier specific for Kv4.1 channels. AU - Yuan,Chunhua, AU - Liao,Zhi, AU - Zeng,Xiongzhi, AU - Dai,Longjun, AU - Kuang,Fang, AU - Liang,Songping, Y1 - 2007/06/03/ PY - 2007/02/15/received PY - 2007/05/15/revised PY - 2007/05/29/accepted PY - 2007/7/17/pubmed PY - 2007/12/12/medline PY - 2007/7/17/entrez SP - 646 EP - 52 JF - Toxicon : official journal of the International Society on Toxinology JO - Toxicon VL - 50 IS - 5 N2 - Jingzhaotoxin-XII (JZTX-XII), a 29-residue polypeptide, was purified from the venom of the Chinese tarantula Chilobrachys jingzhao. Electrophysiological recordings carried out in Xenopus laevis oocytes showed that JZTX-XII is specific for Kv4.1 channels, with the IC50 value of 0.363 microM. It interacts with the channels by modifying the gating behavior. JZTX-XII shares 80% sequence identity with phrixotoxin1, a potent inhibitor for Kv4.2 and Kv4.3 channels. Structure analysis indicates that the difference of the charge distribution in the interactive surface perhaps influences the specific pharmacology of the toxins. JZTX-XII should be a valuable tool for the investigation of the Kv4.1 channels. SN - 0041-0101 UR - https://www.unboundmedicine.com/medline/citation/17631373/Jingzhaotoxin_XII_a_gating_modifier_specific_for_Kv4_1_channels_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-0101(07)00205-X DB - PRIME DP - Unbound Medicine ER -