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Chitotriosidase activity in patients with interstitial lung diseases.
Respir Med. 2007 Oct; 101(10):2176-81.RM

Abstract

BACKGROUND

In previous papers, we found significantly higher activity of chitotriosidase, a macrophage derived enzyme, in serum and BAL of patients with sarcoidosis, especially in those with progressing disease and lung involvement, than in controls. Locally and systemically produced chitotriosidase activity was correlated with radiological stage and also with degree of lung infiltration, suggesting that this enzyme may play a role in the pathogenesis of sarcoidosis and may be used as a marker of disease severity.

AIM

To analyse chitotriosidase activity in serum and bronchoalveolar lavage of patients with idiopathic pulmonary fibrosis and pulmonary fibrosis associated with systemic sclerosis and to compare it with chitotriosidase activity in controls and sarcoidosis patients.

METHODS

Chitotriosidase activity was determined by a fluorometric assay.

RESULTS

The results showed that serum chitotriosidase activity was only elevated in sarcoidosis patients; in patients with idiopathic pulmonary fibrosis and pulmonary fibrosis associated with systemic sclerosis it was in the normal range. On the contrary, in BAL of sarcoidosis and idiopathic pulmonary fibrosis patients the activity was significantly higher than in controls.

CONCLUSION

Serum chitotriosidase is a potential marker of sarcoidosis severity; it increases in sarcoidosis in relation to radiological stage and degree of lung infiltration. The increase in chitotriosidase activity in BAL of sarcoidosis and idiopathic pulmonary fibrosis patients suggests that the enzyme could be involved in fibrogenesis in diffuse lung diseases. Further research is needed to understand the role of chitotriosidase in the pathogenesis of sarcoidosis and its involvement in fibrotic remodelling in certain diffuse lung diseases.

Authors+Show Affiliations

Respiratory Diseases Section, Department of Clinical Medicine and Immunology, Siena University, Italy. bargagli2@unisi.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17631992

Citation

Bargagli, Elena, et al. "Chitotriosidase Activity in Patients With Interstitial Lung Diseases." Respiratory Medicine, vol. 101, no. 10, 2007, pp. 2176-81.
Bargagli E, Margollicci M, Luddi A, et al. Chitotriosidase activity in patients with interstitial lung diseases. Respir Med. 2007;101(10):2176-81.
Bargagli, E., Margollicci, M., Luddi, A., Nikiforakis, N., Perari, M. G., Grosso, S., Perrone, A., & Rottoli, P. (2007). Chitotriosidase activity in patients with interstitial lung diseases. Respiratory Medicine, 101(10), 2176-81.
Bargagli E, et al. Chitotriosidase Activity in Patients With Interstitial Lung Diseases. Respir Med. 2007;101(10):2176-81. PubMed PMID: 17631992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chitotriosidase activity in patients with interstitial lung diseases. AU - Bargagli,Elena, AU - Margollicci,Maria, AU - Luddi,Alice, AU - Nikiforakis,Nicolaos, AU - Perari,Maria Grazia, AU - Grosso,Salvatore, AU - Perrone,Anna, AU - Rottoli,Paola, Y1 - 2007/07/13/ PY - 2006/10/27/received PY - 2007/05/03/revised PY - 2007/05/06/accepted PY - 2007/7/17/pubmed PY - 2008/2/22/medline PY - 2007/7/17/entrez SP - 2176 EP - 81 JF - Respiratory medicine JO - Respir Med VL - 101 IS - 10 N2 - BACKGROUND: In previous papers, we found significantly higher activity of chitotriosidase, a macrophage derived enzyme, in serum and BAL of patients with sarcoidosis, especially in those with progressing disease and lung involvement, than in controls. Locally and systemically produced chitotriosidase activity was correlated with radiological stage and also with degree of lung infiltration, suggesting that this enzyme may play a role in the pathogenesis of sarcoidosis and may be used as a marker of disease severity. AIM: To analyse chitotriosidase activity in serum and bronchoalveolar lavage of patients with idiopathic pulmonary fibrosis and pulmonary fibrosis associated with systemic sclerosis and to compare it with chitotriosidase activity in controls and sarcoidosis patients. METHODS: Chitotriosidase activity was determined by a fluorometric assay. RESULTS: The results showed that serum chitotriosidase activity was only elevated in sarcoidosis patients; in patients with idiopathic pulmonary fibrosis and pulmonary fibrosis associated with systemic sclerosis it was in the normal range. On the contrary, in BAL of sarcoidosis and idiopathic pulmonary fibrosis patients the activity was significantly higher than in controls. CONCLUSION: Serum chitotriosidase is a potential marker of sarcoidosis severity; it increases in sarcoidosis in relation to radiological stage and degree of lung infiltration. The increase in chitotriosidase activity in BAL of sarcoidosis and idiopathic pulmonary fibrosis patients suggests that the enzyme could be involved in fibrogenesis in diffuse lung diseases. Further research is needed to understand the role of chitotriosidase in the pathogenesis of sarcoidosis and its involvement in fibrotic remodelling in certain diffuse lung diseases. SN - 0954-6111 UR - https://www.unboundmedicine.com/medline/citation/17631992/Chitotriosidase_activity_in_patients_with_interstitial_lung_diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0954-6111(07)00195-3 DB - PRIME DP - Unbound Medicine ER -