Tags

Type your tag names separated by a space and hit enter

Partial response to intranasal desmopressin in children with monosymptomatic nocturnal enuresis is related to persistent nocturnal polyuria on wet nights.
J Urol. 2007 Sep; 178(3 Pt 1):1048-51; discussion 1051-2.JU

Abstract

PURPOSE

The anti-incontinence effect of desmopressin resides in its concentrating capacity and antidiuretic properties. We compared nighttime urine production on wet and dry nights in a highly selected study population of children with monosymptomatic nocturnal enuresis associated with proved nocturnal polyuria who responded only partially to intranasal desmopressin.

MATERIALS AND METHODS

We retrospectively analyzed 39 home recordings of nocturnal urine production and maximum voided volume in children 7 to 19 years old (median 8.9) with monosymptomatic nocturnal enuresis with nocturnal polyuria who had a partial response to desmopressin. Nocturnal diuresis volume and maximum voided volume were documented at baseline (14 days) and during 3 months of followup.

RESULTS

Baseline nocturnal urine output (439 +/- 39 ml) was significantly higher than the maximum voided volume (346 +/- 93 ml, p <0.01). During desmopressin treatment nocturnal urine output on wet nights (405 +/- 113 ml) differed significantly from that on dry nights (241 +/- 45 ml). During treatment nocturnal urine output on wet nights did not differ from baseline values.

CONCLUSIONS

Persistence of nocturnal polyuria on wet nights in partial desmopressin responders may be related to an insufficient antidiuretic effect. In addition to poor compliance and suboptimal dosing, the poor bioavailability of intranasal desmopressin may be a pathogenic factor. Further prospective studies are needed.

Authors+Show Affiliations

Department of Pediatric Nephrology, University Hospital Ghent, Ghent, Belgium. Ann.Raes@ugent.beNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17632162

Citation

Raes, A, et al. "Partial Response to Intranasal Desmopressin in Children With Monosymptomatic Nocturnal Enuresis Is Related to Persistent Nocturnal Polyuria On Wet Nights." The Journal of Urology, vol. 178, no. 3 Pt 1, 2007, pp. 1048-51; discussion 1051-2.
Raes A, Dehoorne J, Van Laecke E, et al. Partial response to intranasal desmopressin in children with monosymptomatic nocturnal enuresis is related to persistent nocturnal polyuria on wet nights. J Urol. 2007;178(3 Pt 1):1048-51; discussion 1051-2.
Raes, A., Dehoorne, J., Van Laecke, E., Hoebeke, P., Vande Walle, C., Vansintjan, P., Donckerwolcke, R., & Vande Walle, J. (2007). Partial response to intranasal desmopressin in children with monosymptomatic nocturnal enuresis is related to persistent nocturnal polyuria on wet nights. The Journal of Urology, 178(3 Pt 1), 1048-51; discussion 1051-2.
Raes A, et al. Partial Response to Intranasal Desmopressin in Children With Monosymptomatic Nocturnal Enuresis Is Related to Persistent Nocturnal Polyuria On Wet Nights. J Urol. 2007;178(3 Pt 1):1048-51; discussion 1051-2. PubMed PMID: 17632162.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Partial response to intranasal desmopressin in children with monosymptomatic nocturnal enuresis is related to persistent nocturnal polyuria on wet nights. AU - Raes,A, AU - Dehoorne,J, AU - Van Laecke,E, AU - Hoebeke,P, AU - Vande Walle,C, AU - Vansintjan,P, AU - Donckerwolcke,R, AU - Vande Walle,J, Y1 - 2007/07/16/ PY - 2007/01/16/received PY - 2007/7/17/pubmed PY - 2007/10/3/medline PY - 2007/7/17/entrez SP - 1048-51; discussion 1051-2 JF - The Journal of urology JO - J Urol VL - 178 IS - 3 Pt 1 N2 - PURPOSE: The anti-incontinence effect of desmopressin resides in its concentrating capacity and antidiuretic properties. We compared nighttime urine production on wet and dry nights in a highly selected study population of children with monosymptomatic nocturnal enuresis associated with proved nocturnal polyuria who responded only partially to intranasal desmopressin. MATERIALS AND METHODS: We retrospectively analyzed 39 home recordings of nocturnal urine production and maximum voided volume in children 7 to 19 years old (median 8.9) with monosymptomatic nocturnal enuresis with nocturnal polyuria who had a partial response to desmopressin. Nocturnal diuresis volume and maximum voided volume were documented at baseline (14 days) and during 3 months of followup. RESULTS: Baseline nocturnal urine output (439 +/- 39 ml) was significantly higher than the maximum voided volume (346 +/- 93 ml, p <0.01). During desmopressin treatment nocturnal urine output on wet nights (405 +/- 113 ml) differed significantly from that on dry nights (241 +/- 45 ml). During treatment nocturnal urine output on wet nights did not differ from baseline values. CONCLUSIONS: Persistence of nocturnal polyuria on wet nights in partial desmopressin responders may be related to an insufficient antidiuretic effect. In addition to poor compliance and suboptimal dosing, the poor bioavailability of intranasal desmopressin may be a pathogenic factor. Further prospective studies are needed. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/17632162/Partial_response_to_intranasal_desmopressin_in_children_with_monosymptomatic_nocturnal_enuresis_is_related_to_persistent_nocturnal_polyuria_on_wet_nights_ L2 - https://www.jurology.com/doi/10.1016/j.juro.2007.05.060?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -