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Lifestyle, occupational, and reproductive factors in relation to pancreatic cancer risk.
Pancreas 2007; 35(2):120-9P

Abstract

OBJECTIVES

This study examined the epidemiology of pancreatic cancer in Egypt.

METHODS

We obtained detailed information on smoking, occupational, medical, and reproductive histories from 194 pancreatic cancer cases and 194 controls.

RESULTS

Compared with not smoking, smoking cigarettes alone or in conjunction with other smoking methods (eg, water pipe, cigar) was associated with an increased risk (odds ratio [OR], 4.5 and 7.8; 95% confidence interval [95% CI], 1.9-10.7 and 3.0-20.6, respectively). Passive smoking was also a significant risk factor (OR, 6.0; 95% CI, 2.4-14.8). The risk of pancreatic cancer was elevated among subjects exposed to pesticides (OR, 2.6; 95% CI, 0.97-7.2). A prior diagnosis of diabetes mellitus for a period of 10 years was associated with higher risk (OR, 5.4; 95% CI, 1.5-19.9). For women, having 7 or more live births and lactating for 144 months or longer were associated with a reduced risk (OR, 0.5 and 0.2; 95% CI, 0.2-1.3 and 0.1-0.9, respectively). No association was found between family history, allergy, or obesity and pancreatic cancer in Egypt.

CONCLUSIONS

Multiple tobacco consumption methods, passive smoking, pesticide exposures, and diabetes are associated with an increased risk for pancreatic cancer. Prolonged lactation and increased parity are associated with a reduced risk for pancreatic cancer.

Authors+Show Affiliations

Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17632317

Citation

Lo, An-Chi, et al. "Lifestyle, Occupational, and Reproductive Factors in Relation to Pancreatic Cancer Risk." Pancreas, vol. 35, no. 2, 2007, pp. 120-9.
Lo AC, Soliman AS, El-Ghawalby N, et al. Lifestyle, occupational, and reproductive factors in relation to pancreatic cancer risk. Pancreas. 2007;35(2):120-9.
Lo, A. C., Soliman, A. S., El-Ghawalby, N., Abdel-Wahab, M., Fathy, O., Khaled, H. M., ... Abbruzzese, J. L. (2007). Lifestyle, occupational, and reproductive factors in relation to pancreatic cancer risk. Pancreas, 35(2), pp. 120-9.
Lo AC, et al. Lifestyle, Occupational, and Reproductive Factors in Relation to Pancreatic Cancer Risk. Pancreas. 2007;35(2):120-9. PubMed PMID: 17632317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lifestyle, occupational, and reproductive factors in relation to pancreatic cancer risk. AU - Lo,An-Chi, AU - Soliman,Amr S, AU - El-Ghawalby,Nabih, AU - Abdel-Wahab,Mohamed, AU - Fathy,Omar, AU - Khaled,Hussein M, AU - Omar,Sherif, AU - Hamilton,Stanley R, AU - Greenson,Joel K, AU - Abbruzzese,James L, PY - 2007/7/17/pubmed PY - 2007/9/26/medline PY - 2007/7/17/entrez SP - 120 EP - 9 JF - Pancreas JO - Pancreas VL - 35 IS - 2 N2 - OBJECTIVES: This study examined the epidemiology of pancreatic cancer in Egypt. METHODS: We obtained detailed information on smoking, occupational, medical, and reproductive histories from 194 pancreatic cancer cases and 194 controls. RESULTS: Compared with not smoking, smoking cigarettes alone or in conjunction with other smoking methods (eg, water pipe, cigar) was associated with an increased risk (odds ratio [OR], 4.5 and 7.8; 95% confidence interval [95% CI], 1.9-10.7 and 3.0-20.6, respectively). Passive smoking was also a significant risk factor (OR, 6.0; 95% CI, 2.4-14.8). The risk of pancreatic cancer was elevated among subjects exposed to pesticides (OR, 2.6; 95% CI, 0.97-7.2). A prior diagnosis of diabetes mellitus for a period of 10 years was associated with higher risk (OR, 5.4; 95% CI, 1.5-19.9). For women, having 7 or more live births and lactating for 144 months or longer were associated with a reduced risk (OR, 0.5 and 0.2; 95% CI, 0.2-1.3 and 0.1-0.9, respectively). No association was found between family history, allergy, or obesity and pancreatic cancer in Egypt. CONCLUSIONS: Multiple tobacco consumption methods, passive smoking, pesticide exposures, and diabetes are associated with an increased risk for pancreatic cancer. Prolonged lactation and increased parity are associated with a reduced risk for pancreatic cancer. SN - 1536-4828 UR - https://www.unboundmedicine.com/medline/citation/17632317/Lifestyle_occupational_and_reproductive_factors_in_relation_to_pancreatic_cancer_risk_ L2 - http://Insights.ovid.com/pubmed?pmid=17632317 DB - PRIME DP - Unbound Medicine ER -