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[Case of malignant hyperthermia in which treatment was carried out smoothly].
Masui. 2007 Jul; 56(7):826-30.M

Abstract

We experienced a case of the abortive malignant hyperthermia (MH) that had developed during operation. The patient was a 14-year-old girl, and plastic surgery was scheduled under general anesthesia. Serum creatine kinase (CK) levels were high with 505 IU x l(-1) at the preoperative examination. General anesthesia was induced with propofol and vecuronium bromide, and maintained with sevoflurane. Suddenly, sinus tachycardia of an uncertain cause and a rapid rise of end-tidal carbon dioxide (Et(CO2)) concentration were noticed. Since we suspected MH, we did cooling and hyperventilation and administered dantrolene sodium 2 mg x kg(-1) for the patient. As a result, the highest temperature remained at 37.6 degrees C. Serum CK levels increased most postoperative 18 hours later and it is improved gradually. As sevoflurane, promotes the CICR (calcium-induced calcium release) mechanism, the trigger of this case is probably sevoflurane. As for the symptom that makes us doubt MH first, there is a maked rapid rises of Et(CO2). Therefore, it is important monitor and recognize the first symptom of MH.

Authors+Show Affiliations

Department of Dental Anesthesiology, Aizu Chuo Hospital, Aizuwakamatsu.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

jpn

PubMed ID

17633846

Citation

Morota, Tomoko, et al. "[Case of Malignant Hyperthermia in Which Treatment Was Carried Out Smoothly]." Masui. the Japanese Journal of Anesthesiology, vol. 56, no. 7, 2007, pp. 826-30.
Morota T, Endo K, Furuta S, et al. [Case of malignant hyperthermia in which treatment was carried out smoothly]. Masui. 2007;56(7):826-30.
Morota, T., Endo, K., Furuta, S., Obara, S., Ohmuzo, H., Kaneko, T., Onuma, T., & Watanabe, K. (2007). [Case of malignant hyperthermia in which treatment was carried out smoothly]. Masui. the Japanese Journal of Anesthesiology, 56(7), 826-30.
Morota T, et al. [Case of Malignant Hyperthermia in Which Treatment Was Carried Out Smoothly]. Masui. 2007;56(7):826-30. PubMed PMID: 17633846.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Case of malignant hyperthermia in which treatment was carried out smoothly]. AU - Morota,Tomoko, AU - Endo,Katsuya, AU - Furuta,Setsuo, AU - Obara,Shinju, AU - Ohmuzo,Hiroshi, AU - Kaneko,Toshikazu, AU - Onuma,Toshiyasu, AU - Watanabe,Kazuhiro, PY - 2007/7/20/pubmed PY - 2007/8/19/medline PY - 2007/7/20/entrez SP - 826 EP - 30 JF - Masui. The Japanese journal of anesthesiology JO - Masui VL - 56 IS - 7 N2 - We experienced a case of the abortive malignant hyperthermia (MH) that had developed during operation. The patient was a 14-year-old girl, and plastic surgery was scheduled under general anesthesia. Serum creatine kinase (CK) levels were high with 505 IU x l(-1) at the preoperative examination. General anesthesia was induced with propofol and vecuronium bromide, and maintained with sevoflurane. Suddenly, sinus tachycardia of an uncertain cause and a rapid rise of end-tidal carbon dioxide (Et(CO2)) concentration were noticed. Since we suspected MH, we did cooling and hyperventilation and administered dantrolene sodium 2 mg x kg(-1) for the patient. As a result, the highest temperature remained at 37.6 degrees C. Serum CK levels increased most postoperative 18 hours later and it is improved gradually. As sevoflurane, promotes the CICR (calcium-induced calcium release) mechanism, the trigger of this case is probably sevoflurane. As for the symptom that makes us doubt MH first, there is a maked rapid rises of Et(CO2). Therefore, it is important monitor and recognize the first symptom of MH. SN - 0021-4892 UR - https://www.unboundmedicine.com/medline/citation/17633846/[Case_of_malignant_hyperthermia_in_which_treatment_was_carried_out_smoothly]_ L2 - http://www.diseaseinfosearch.org/result/4424 DB - PRIME DP - Unbound Medicine ER -