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Molecular study of microsporidiosis due to Enterocytozoon bieneusi and Encephalitozoon intestinalis among human immunodeficiency virus-infected patients from two geographical areas: Niamey, Niger, and Hanoi, Vietnam.
J Clin Microbiol. 2007 Sep; 45(9):2999-3002.JC

Abstract

Microsporidiosis cases due to Enterocytozoon bieneusi and Encephalitozoon intestinalis are emerging opportunistic infections associated with a wide range of clinical syndromes in humans. The aim of this study was to specify microsporidial epidemiology in two different geographical areas. From November 2004 to August 2005, 228 and 42 stool samples were collected in Niamey, Niger, and Hanoi, Vietnam, respectively. Screening for microsporidia was performed using UV-light microscopy. Detection was confirmed by molecular biology using two methods specific for E. bieneusi and E. intestinalis. All samples positive for E. bieneusi were subjected to genotyping. In this study, we found high prevalences of microsporidiosis among human immunodeficiency virus-infected patients, 10.5% and 9.5%, respectively, in Niamey and Hanoi. These levels of prevalence are similar to those recorded in European countries before highly active antiretroviral therapy was introduced. In the samples positive for E. bieneusi, we found seven distinct genotypes, including two genotypes not previously described. The E. bieneusi genotype distributions in the two geographical areas suggest different routes of infection transmission, person-to-person in Niger and zoonotic in Vietnam.

Authors+Show Affiliations

Laboratory of Parasitology and Mycology, Nantes University Hospital, Nantes, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17634305

Citation

Espern, Anne, et al. "Molecular Study of Microsporidiosis Due to Enterocytozoon Bieneusi and Encephalitozoon Intestinalis Among Human Immunodeficiency Virus-infected Patients From Two Geographical Areas: Niamey, Niger, and Hanoi, Vietnam." Journal of Clinical Microbiology, vol. 45, no. 9, 2007, pp. 2999-3002.
Espern A, Morio F, Miegeville M, et al. Molecular study of microsporidiosis due to Enterocytozoon bieneusi and Encephalitozoon intestinalis among human immunodeficiency virus-infected patients from two geographical areas: Niamey, Niger, and Hanoi, Vietnam. J Clin Microbiol. 2007;45(9):2999-3002.
Espern, A., Morio, F., Miegeville, M., Illa, H., Abdoulaye, M., Meyssonnier, V., Adehossi, E., Lejeune, A., Cam, P. D., Besse, B., & Gay-Andrieu, F. (2007). Molecular study of microsporidiosis due to Enterocytozoon bieneusi and Encephalitozoon intestinalis among human immunodeficiency virus-infected patients from two geographical areas: Niamey, Niger, and Hanoi, Vietnam. Journal of Clinical Microbiology, 45(9), 2999-3002.
Espern A, et al. Molecular Study of Microsporidiosis Due to Enterocytozoon Bieneusi and Encephalitozoon Intestinalis Among Human Immunodeficiency Virus-infected Patients From Two Geographical Areas: Niamey, Niger, and Hanoi, Vietnam. J Clin Microbiol. 2007;45(9):2999-3002. PubMed PMID: 17634305.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular study of microsporidiosis due to Enterocytozoon bieneusi and Encephalitozoon intestinalis among human immunodeficiency virus-infected patients from two geographical areas: Niamey, Niger, and Hanoi, Vietnam. AU - Espern,Anne, AU - Morio,Florent, AU - Miegeville,Michel, AU - Illa,Hachimou, AU - Abdoulaye,Moustapha, AU - Meyssonnier,Vanina, AU - Adehossi,Eric, AU - Lejeune,Anne, AU - Cam,Phung Dac, AU - Besse,Bernard, AU - Gay-Andrieu,Françoise, Y1 - 2007/07/18/ PY - 2007/7/20/pubmed PY - 2007/11/7/medline PY - 2007/7/20/entrez SP - 2999 EP - 3002 JF - Journal of clinical microbiology JO - J Clin Microbiol VL - 45 IS - 9 N2 - Microsporidiosis cases due to Enterocytozoon bieneusi and Encephalitozoon intestinalis are emerging opportunistic infections associated with a wide range of clinical syndromes in humans. The aim of this study was to specify microsporidial epidemiology in two different geographical areas. From November 2004 to August 2005, 228 and 42 stool samples were collected in Niamey, Niger, and Hanoi, Vietnam, respectively. Screening for microsporidia was performed using UV-light microscopy. Detection was confirmed by molecular biology using two methods specific for E. bieneusi and E. intestinalis. All samples positive for E. bieneusi were subjected to genotyping. In this study, we found high prevalences of microsporidiosis among human immunodeficiency virus-infected patients, 10.5% and 9.5%, respectively, in Niamey and Hanoi. These levels of prevalence are similar to those recorded in European countries before highly active antiretroviral therapy was introduced. In the samples positive for E. bieneusi, we found seven distinct genotypes, including two genotypes not previously described. The E. bieneusi genotype distributions in the two geographical areas suggest different routes of infection transmission, person-to-person in Niger and zoonotic in Vietnam. SN - 0095-1137 UR - https://www.unboundmedicine.com/medline/citation/17634305/Molecular_study_of_microsporidiosis_due_to_Enterocytozoon_bieneusi_and_Encephalitozoon_intestinalis_among_human_immunodeficiency_virus_infected_patients_from_two_geographical_areas:_Niamey_Niger_and_Hanoi_Vietnam_ L2 - http://jcm.asm.org/cgi/pmidlookup?view=long&pmid=17634305 DB - PRIME DP - Unbound Medicine ER -