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Morbidity and mortality risk associated with an overweight BMI in older men and women.

Abstract

BACKGROUND

There is controversy as to whether older adults with a BMI in the overweight range (25 to 29.9 kg/m2) are at increased health risk and whether they should be encouraged to lose weight. The purpose of this study was to determine whether older adults with a BMI in the overweight range are at increased morbidity and mortality risk.

METHODS

Participants consisted of 4968 older (>or=65 years) men and women from the Cardiovascular Health Study limited access dataset. Based on BMI (kg/m2), participants were grouped into normal-weight (20 to 24.9 kg/m2), overweight (25 to 29.9 kg/m2), and obese (>or=30 kg/m2) categories. Participants were followed for up to 9 years to determine if they developed 10 weight-related health outcomes that are pertinent to older adults. Cox proportional hazards models were used to estimate the hazards ratios of morbidity and mortality after adjusting for age, sex, income, smoking, and physical activity.

RESULTS

Compared with the normal-weight group, the risks of myocardial infarction, stroke, sleep apnea, urinary incontinence, cancer, and osteoporosis were not different in the overweight group (p>0.05). The risks for arthritis and physical disability were modestly increased in the overweight group (p<0.05), whereas the risk for type 2 diabetes was increased by 78% in the overweight group (p<0.01). After adjusting for all relevant covariates, all-cause mortality risk was 11% lower in the overweight group (p<0.05).

CONCLUSIONS

A BMI in the overweight range was associated with some modest disease risks but a slightly lower overall mortality rate. These findings suggest that a BMI cut-off point of 25 kg/m2 may be overly restrictive for the elderly.

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  • Authors+Show Affiliations

    School of Kinesiology and Health Studies, Department of Community Health and Epidemiology, Queen's University, Kingston, Ontario, Canada, K7L 3N6. ian.janssen@queensu.ca

    Source

    Obesity (Silver Spring, Md.) 15:7 2007 Jul pg 1827-40

    MeSH

    Aged
    Aged, 80 and over
    Body Mass Index
    Cardiovascular Diseases
    Female
    Follow-Up Studies
    Humans
    Longitudinal Studies
    Male
    Morbidity
    Obesity
    Overweight
    Risk Assessment
    Risk Factors
    Survival Analysis
    Time Factors
    Weight Loss

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17636102

    Citation

    Janssen, Ian. "Morbidity and Mortality Risk Associated With an Overweight BMI in Older Men and Women." Obesity (Silver Spring, Md.), vol. 15, no. 7, 2007, pp. 1827-40.
    Janssen I. Morbidity and mortality risk associated with an overweight BMI in older men and women. Obesity (Silver Spring). 2007;15(7):1827-40.
    Janssen, I. (2007). Morbidity and mortality risk associated with an overweight BMI in older men and women. Obesity (Silver Spring, Md.), 15(7), pp. 1827-40.
    Janssen I. Morbidity and Mortality Risk Associated With an Overweight BMI in Older Men and Women. Obesity (Silver Spring). 2007;15(7):1827-40. PubMed PMID: 17636102.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Morbidity and mortality risk associated with an overweight BMI in older men and women. A1 - Janssen,Ian, PY - 2007/7/20/pubmed PY - 2007/10/30/medline PY - 2007/7/20/entrez SP - 1827 EP - 40 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 15 IS - 7 N2 - BACKGROUND: There is controversy as to whether older adults with a BMI in the overweight range (25 to 29.9 kg/m2) are at increased health risk and whether they should be encouraged to lose weight. The purpose of this study was to determine whether older adults with a BMI in the overweight range are at increased morbidity and mortality risk. METHODS: Participants consisted of 4968 older (>or=65 years) men and women from the Cardiovascular Health Study limited access dataset. Based on BMI (kg/m2), participants were grouped into normal-weight (20 to 24.9 kg/m2), overweight (25 to 29.9 kg/m2), and obese (>or=30 kg/m2) categories. Participants were followed for up to 9 years to determine if they developed 10 weight-related health outcomes that are pertinent to older adults. Cox proportional hazards models were used to estimate the hazards ratios of morbidity and mortality after adjusting for age, sex, income, smoking, and physical activity. RESULTS: Compared with the normal-weight group, the risks of myocardial infarction, stroke, sleep apnea, urinary incontinence, cancer, and osteoporosis were not different in the overweight group (p>0.05). The risks for arthritis and physical disability were modestly increased in the overweight group (p<0.05), whereas the risk for type 2 diabetes was increased by 78% in the overweight group (p<0.01). After adjusting for all relevant covariates, all-cause mortality risk was 11% lower in the overweight group (p<0.05). CONCLUSIONS: A BMI in the overweight range was associated with some modest disease risks but a slightly lower overall mortality rate. These findings suggest that a BMI cut-off point of 25 kg/m2 may be overly restrictive for the elderly. SN - 1930-7381 UR - https://www.unboundmedicine.com/medline/citation/17636102/Morbidity_and_mortality_risk_associated_with_an_overweight_BMI_in_older_men_and_women_ L2 - https://doi.org/10.1038/oby.2007.217 DB - PRIME DP - Unbound Medicine ER -