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Application of GnRH antagonist in combination with clomiphene citrate and hMG for patients with exaggerated ovarian response in previous IVF/ICSI cycles.
J Assist Reprod Genet. 2007 Aug; 24(8):331-6.JA

Abstract

PURPOSE

To investigate if the combination of clomiphene citrate, hMG, and cetrorelix (CC/hMG/cetrorelix protocol) can be applied to patients who had excessive response to GnRHa long protocol.

METHODS

Fifty patients who coasted and failed to conceive in their first cycles stimulated with GnRHa long protocol were stimulated with CC/hMG/cetrorelix protocol. The peak serum estradiol levels, the need of coasting and prolonged coasting (>/=4 days), and the incidences of OHSS were compared.

RESULTS

The peak estradiol level was significantly lower with CC/hMG/cetrorelix protocol compared to GnRHa long protocol. With CC/hMG/cetrorelix protocol, only four patients (8%) needed coasting and no one coasted >/=4 days. In contrast, in the first cycles, 11 patients (22%) needed coasting >/=4 days. The incidence of moderate OHSS was significantly lower with CC/hMG/cetrorelix protocol.

CONCLUSIONS

The CC/hMG/cetrorelix protocol is an acceptable alternative protocol for patients who had excessive response to GnRHa long protocol.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, No. 95 Wen Chang Road, Shih Lin District, Taipei, 111, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17636445

Citation

Lin, Yu-Hung, et al. "Application of GnRH Antagonist in Combination With Clomiphene Citrate and hMG for Patients With Exaggerated Ovarian Response in Previous IVF/ICSI Cycles." Journal of Assisted Reproduction and Genetics, vol. 24, no. 8, 2007, pp. 331-6.
Lin YH, Seow KM, Hsieh BC, et al. Application of GnRH antagonist in combination with clomiphene citrate and hMG for patients with exaggerated ovarian response in previous IVF/ICSI cycles. J Assist Reprod Genet. 2007;24(8):331-6.
Lin, Y. H., Seow, K. M., Hsieh, B. C., Huang, L. W., Chen, H. J., Huang, S. C., Chen, C. Y., Chen, P. H., Hwang, J. L., & Tzeng, C. R. (2007). Application of GnRH antagonist in combination with clomiphene citrate and hMG for patients with exaggerated ovarian response in previous IVF/ICSI cycles. Journal of Assisted Reproduction and Genetics, 24(8), 331-6.
Lin YH, et al. Application of GnRH Antagonist in Combination With Clomiphene Citrate and hMG for Patients With Exaggerated Ovarian Response in Previous IVF/ICSI Cycles. J Assist Reprod Genet. 2007;24(8):331-6. PubMed PMID: 17636445.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Application of GnRH antagonist in combination with clomiphene citrate and hMG for patients with exaggerated ovarian response in previous IVF/ICSI cycles. AU - Lin,Yu-Hung, AU - Seow,Kok-Min, AU - Hsieh,Bih-Chwen, AU - Huang,Lee-Wen, AU - Chen,Heng-Ju, AU - Huang,Shih-Chia, AU - Chen,Chih-Yu, AU - Chen,Pei-Hsin, AU - Hwang,Jiann-Loung, AU - Tzeng,Chi-Ruey, Y1 - 2007/07/17/ PY - 2006/12/04/received PY - 2007/03/12/accepted PY - 2007/7/20/pubmed PY - 2007/11/6/medline PY - 2007/7/20/entrez SP - 331 EP - 6 JF - Journal of assisted reproduction and genetics JO - J Assist Reprod Genet VL - 24 IS - 8 N2 - PURPOSE: To investigate if the combination of clomiphene citrate, hMG, and cetrorelix (CC/hMG/cetrorelix protocol) can be applied to patients who had excessive response to GnRHa long protocol. METHODS: Fifty patients who coasted and failed to conceive in their first cycles stimulated with GnRHa long protocol were stimulated with CC/hMG/cetrorelix protocol. The peak serum estradiol levels, the need of coasting and prolonged coasting (>/=4 days), and the incidences of OHSS were compared. RESULTS: The peak estradiol level was significantly lower with CC/hMG/cetrorelix protocol compared to GnRHa long protocol. With CC/hMG/cetrorelix protocol, only four patients (8%) needed coasting and no one coasted >/=4 days. In contrast, in the first cycles, 11 patients (22%) needed coasting >/=4 days. The incidence of moderate OHSS was significantly lower with CC/hMG/cetrorelix protocol. CONCLUSIONS: The CC/hMG/cetrorelix protocol is an acceptable alternative protocol for patients who had excessive response to GnRHa long protocol. SN - 1058-0468 UR - https://www.unboundmedicine.com/medline/citation/17636445/Application_of_GnRH_antagonist_in_combination_with_clomiphene_citrate_and_hMG_for_patients_with_exaggerated_ovarian_response_in_previous_IVF/ICSI_cycles_ L2 - https://doi.org/10.1007/s10815-007-9127-8 DB - PRIME DP - Unbound Medicine ER -