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WITHDRAWN: Maternal antigen avoidance during lactation for preventing atopic disease in infants of women at high risk.
Cochrane Database Syst Rev 2007; (4):CD000132CD

Abstract

BACKGROUND

Background pending.

OBJECTIVES

To assess the effects of prescribing an antigen avoidance diet during lactation on the nutritional status of the mother and newborn and on the development of atopic disease in the child. The main focus is on women whose infants are at high risk for developing an atopic condition, based on a history of atopic disease in the mother, father, or a previous child.

SEARCH STRATEGY

The register of clinical trials maintained and updated by the Cochrane Pregnancy and Childbirth Group. Date of last search: October 2001.

SELECTION CRITERIA

All acceptably controlled comparisons of maternal antigen avoidance prescribed to lactating women at high risk, regardless of the degree of antigen avoidance (number of foods eliminated from the diet) or its duration. Trials of multimodal interventions that include manipulation of the infant's diet other than breast milk or of other nondietary aspects of the infant's environment (eg, exposure to inhaled allergens) have been excluded from the review.

DATA COLLECTION AND ANALYSIS

Data were extracted by the author from published reports, and supplemented by additional information from trialists contacted by the author.

MAIN RESULTS

Three trials involving 209 women were included. The combined data from the three available trials suggest a strong protective effect of maternal antigen avoidance on the incidence of atopic eczema during the child's first 12-18 months of life. Methodologic shortcomings in all three trials, however, argue for caution in applying these encouraging results. In particular, the high incidence of atopic eczema in the control groups of all three trials might be explained by nonblinding or de-blinding of the examining physicians.

AUTHORS' CONCLUSIONS

Prescription of an antigen avoidance diet to a high-risk woman during lactation may substantially reduce her child's risk of developing atopic eczema, but better trials are needed.

Authors+Show Affiliations

McGill University, Faculty of Medicine, 1020 Pine Avenue West, Montreal, Quebec, Canada, H3A 1A2. michael.kramer@mcgill.ca

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

17636599

Citation

Kramer, M S.. "WITHDRAWN: Maternal Antigen Avoidance During Lactation for Preventing Atopic Disease in Infants of Women at High Risk." The Cochrane Database of Systematic Reviews, 2007, p. CD000132.
Kramer MS. WITHDRAWN: Maternal antigen avoidance during lactation for preventing atopic disease in infants of women at high risk. Cochrane Database Syst Rev. 2007.
Kramer, M. S. (2007). WITHDRAWN: Maternal antigen avoidance during lactation for preventing atopic disease in infants of women at high risk. The Cochrane Database of Systematic Reviews, (4), p. CD000132.
Kramer MS. WITHDRAWN: Maternal Antigen Avoidance During Lactation for Preventing Atopic Disease in Infants of Women at High Risk. Cochrane Database Syst Rev. 2007 Jul 18;(4)CD000132. PubMed PMID: 17636599.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - WITHDRAWN: Maternal antigen avoidance during lactation for preventing atopic disease in infants of women at high risk. A1 - Kramer,M S, Y1 - 2007/07/18/ PY - 2007/7/20/pubmed PY - 2007/10/19/medline PY - 2007/7/20/entrez SP - CD000132 EP - CD000132 JF - The Cochrane database of systematic reviews JO - Cochrane Database Syst Rev IS - 4 N2 - BACKGROUND: Background pending. OBJECTIVES: To assess the effects of prescribing an antigen avoidance diet during lactation on the nutritional status of the mother and newborn and on the development of atopic disease in the child. The main focus is on women whose infants are at high risk for developing an atopic condition, based on a history of atopic disease in the mother, father, or a previous child. SEARCH STRATEGY: The register of clinical trials maintained and updated by the Cochrane Pregnancy and Childbirth Group. Date of last search: October 2001. SELECTION CRITERIA: All acceptably controlled comparisons of maternal antigen avoidance prescribed to lactating women at high risk, regardless of the degree of antigen avoidance (number of foods eliminated from the diet) or its duration. Trials of multimodal interventions that include manipulation of the infant's diet other than breast milk or of other nondietary aspects of the infant's environment (eg, exposure to inhaled allergens) have been excluded from the review. DATA COLLECTION AND ANALYSIS: Data were extracted by the author from published reports, and supplemented by additional information from trialists contacted by the author. MAIN RESULTS: Three trials involving 209 women were included. The combined data from the three available trials suggest a strong protective effect of maternal antigen avoidance on the incidence of atopic eczema during the child's first 12-18 months of life. Methodologic shortcomings in all three trials, however, argue for caution in applying these encouraging results. In particular, the high incidence of atopic eczema in the control groups of all three trials might be explained by nonblinding or de-blinding of the examining physicians. AUTHORS' CONCLUSIONS: Prescription of an antigen avoidance diet to a high-risk woman during lactation may substantially reduce her child's risk of developing atopic eczema, but better trials are needed. SN - 1469-493X UR - https://www.unboundmedicine.com/medline/citation/17636599/WITHDRAWN:_Maternal_antigen_avoidance_during_lactation_for_preventing_atopic_disease_in_infants_of_women_at_high_risk_ L2 - https://doi.org/10.1002/14651858.CD000132 DB - PRIME DP - Unbound Medicine ER -