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Predictors of low bone mineral density in the elderly: the role of dietary intake, nutritional status and sarcopenia.
Eur J Clin Nutr 2008; 62(6):802-9EJ

Abstract

OBJECTIVES

The aims of this study were to investigate the relationship between sarcopenia, dietary intake, nutritional indices and hip bone mineral density (BMD) in the elderly, and to estimate the risk of low BMD due to specific independent predictor thresholds.

SUBJECTS AND METHODS

Body mass index (BMI), serum albumin, energy and protein intake were studied in 352 elderly outpatients (216 women aged 73.5+/-5.3 years and 136 men aged 73.9+/-5.6 years). BMD at different hip sites and appendicular skeletal muscle mass (ASMM) were assessed by dual-energy X-ray absorptiometry.

RESULTS

The prevalence of osteoporosis was 13% in men and 45% in women, while the prevalence of sarcopenia (50%) and hypoalbuminemia (5%) were similar in both genders. BMI, albumin and ASMM were significantly associated with BMD in both genders: so was protein intake, but only in men. By multiple regression analysis, the variables that retained their independent explanatory role on total hip BMD, were BMI and protein intake in men, and BMI and albumin in women. By logistic regression analysis, men risked having a low BMD with a BMI <22 (OR=12) and a protein intake <65.7 g/day (OR=3.7). Women carried some risk already in the BMI 25-30 class (OR=5), and a much greater risk in the BMI <22 class (OR=26). Albumin <40 g/l also emerged as an independent risk factor (OR=2.6).

CONCLUSIONS

BMI in both genders, albumin in women and protein intake in men have an independent effect on BMD. BMI values <22 are normal for younger adults but carry a higher risk of osteoporosis in the elderly, particularly in women. Age-related sarcopenia does not seem to be involved in bone mass loss.

Authors+Show Affiliations

Department of Medical and Surgical Sciences, Geriatrics Unit, University of Padova, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17637603

Citation

Coin, A, et al. "Predictors of Low Bone Mineral Density in the Elderly: the Role of Dietary Intake, Nutritional Status and Sarcopenia." European Journal of Clinical Nutrition, vol. 62, no. 6, 2008, pp. 802-9.
Coin A, Perissinotto E, Enzi G, et al. Predictors of low bone mineral density in the elderly: the role of dietary intake, nutritional status and sarcopenia. Eur J Clin Nutr. 2008;62(6):802-9.
Coin, A., Perissinotto, E., Enzi, G., Zamboni, M., Inelmen, E. M., Frigo, A. C., ... Sergi, G. (2008). Predictors of low bone mineral density in the elderly: the role of dietary intake, nutritional status and sarcopenia. European Journal of Clinical Nutrition, 62(6), pp. 802-9.
Coin A, et al. Predictors of Low Bone Mineral Density in the Elderly: the Role of Dietary Intake, Nutritional Status and Sarcopenia. Eur J Clin Nutr. 2008;62(6):802-9. PubMed PMID: 17637603.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predictors of low bone mineral density in the elderly: the role of dietary intake, nutritional status and sarcopenia. AU - Coin,A, AU - Perissinotto,E, AU - Enzi,G, AU - Zamboni,M, AU - Inelmen,E M, AU - Frigo,A C, AU - Manzato,E, AU - Busetto,L, AU - Buja,A, AU - Sergi,G, Y1 - 2007/07/18/ PY - 2007/7/20/pubmed PY - 2008/10/24/medline PY - 2007/7/20/entrez SP - 802 EP - 9 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 62 IS - 6 N2 - OBJECTIVES: The aims of this study were to investigate the relationship between sarcopenia, dietary intake, nutritional indices and hip bone mineral density (BMD) in the elderly, and to estimate the risk of low BMD due to specific independent predictor thresholds. SUBJECTS AND METHODS: Body mass index (BMI), serum albumin, energy and protein intake were studied in 352 elderly outpatients (216 women aged 73.5+/-5.3 years and 136 men aged 73.9+/-5.6 years). BMD at different hip sites and appendicular skeletal muscle mass (ASMM) were assessed by dual-energy X-ray absorptiometry. RESULTS: The prevalence of osteoporosis was 13% in men and 45% in women, while the prevalence of sarcopenia (50%) and hypoalbuminemia (5%) were similar in both genders. BMI, albumin and ASMM were significantly associated with BMD in both genders: so was protein intake, but only in men. By multiple regression analysis, the variables that retained their independent explanatory role on total hip BMD, were BMI and protein intake in men, and BMI and albumin in women. By logistic regression analysis, men risked having a low BMD with a BMI <22 (OR=12) and a protein intake <65.7 g/day (OR=3.7). Women carried some risk already in the BMI 25-30 class (OR=5), and a much greater risk in the BMI <22 class (OR=26). Albumin <40 g/l also emerged as an independent risk factor (OR=2.6). CONCLUSIONS: BMI in both genders, albumin in women and protein intake in men have an independent effect on BMD. BMI values <22 are normal for younger adults but carry a higher risk of osteoporosis in the elderly, particularly in women. Age-related sarcopenia does not seem to be involved in bone mass loss. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/17637603/Predictors_of_low_bone_mineral_density_in_the_elderly:_the_role_of_dietary_intake_nutritional_status_and_sarcopenia_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602779 DB - PRIME DP - Unbound Medicine ER -