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Risk of wheezing associated with house-dust mite allergens and indoor air quality among three-year-old children. Kraków inner city study.
Int J Occup Med Environ Health 2007; 20(2):117-26IJ

Abstract

OBJECTIVES

The aim of the study was to describe the distribution of house-dust mite (HDM) allergens in homes of three-year-old children and to test the hypothesis whether the content of HDM allergens exceeding 2 microg/g of dust may be regarded as a risk level possibly affecting respiratory health in early childhood.

MATERIALS AND METHODS

House-dust samples were collected in 275 dwellings from mattresses, children's bedrooms and kitchen floors. In the laboratory, dust samples were analyzed for Der f 1 and Der p 1 using monoclonal antibody enzyme-linked immunosorbent assays (ELISA). At the time of the house-dust collection, mothers were interviewed on the household characteristics and their children's respiratory health. Respiratory outcome variables included wheezing or whistling in the chest irrespective of respiratory infections. The number of the wheezing episodes and their duration in days over the last 6 months were recorded in the questionnaire. In the multivariate Poisson regression analysis on the association between the occurrence of wheezing and exposure, a set of potential confounders, such as child's gender, maternal education, maternal allergy, older siblings, presence of moulds, house dampness, and environmental tobacco smoke (ETS) was taken into account.

RESULTS

The adjusted incidence rate ratios (IRR) of wheezing ascribed to a higher HDM level (> 2.0 microg/g dust) were 1.84 (95% CI: 1.45-2.34) for duration of wheezing and 1.56 (95% CI: 0.88-2.75) for episodes. Of the confounders taken into consideration, the presence of moulds had the strongest impact on the risk of wheezing (IRR = 4.24; 95% CI: 3.08-5.84).

CONCLUSION

The data support the view that exposure to a higher level of HDM allergens increases the burden of respiratory diseases in the early childhood and the effect is independent of maternal atopy, ETS, and moulds in homes.

Authors+Show Affiliations

Chair of Epidemiology and Preventive Medicine College of Medicine, Jagiellonian University, Kraków, Poland. myjedryc@cyf-kr.edu.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17638678

Citation

Jeedrychowski, Wiesław, et al. "Risk of Wheezing Associated With House-dust Mite Allergens and Indoor Air Quality Among Three-year-old Children. Kraków Inner City Study." International Journal of Occupational Medicine and Environmental Health, vol. 20, no. 2, 2007, pp. 117-26.
Jeedrychowski W, Maugeri U, Zembala M, et al. Risk of wheezing associated with house-dust mite allergens and indoor air quality among three-year-old children. Kraków inner city study. Int J Occup Med Environ Health. 2007;20(2):117-26.
Jeedrychowski, W., Maugeri, U., Zembala, M., Perzanowski, M. S., Hajto, B., Flak, E., ... Perera, F. P. (2007). Risk of wheezing associated with house-dust mite allergens and indoor air quality among three-year-old children. Kraków inner city study. International Journal of Occupational Medicine and Environmental Health, 20(2), pp. 117-26.
Jeedrychowski W, et al. Risk of Wheezing Associated With House-dust Mite Allergens and Indoor Air Quality Among Three-year-old Children. Kraków Inner City Study. Int J Occup Med Environ Health. 2007;20(2):117-26. PubMed PMID: 17638678.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of wheezing associated with house-dust mite allergens and indoor air quality among three-year-old children. Kraków inner city study. AU - Jeedrychowski,Wiesław, AU - Maugeri,Umberto, AU - Zembala,Marek, AU - Perzanowski,Mattew S, AU - Hajto,Barbara, AU - Flak,Elzbieta, AU - Mróz,Elzbieta, AU - Jacek,Ryszard, AU - Sowa,Agata, AU - Perera,Frederica P, PY - 2007/7/20/pubmed PY - 2007/11/14/medline PY - 2007/7/20/entrez SP - 117 EP - 26 JF - International journal of occupational medicine and environmental health JO - Int J Occup Med Environ Health VL - 20 IS - 2 N2 - OBJECTIVES: The aim of the study was to describe the distribution of house-dust mite (HDM) allergens in homes of three-year-old children and to test the hypothesis whether the content of HDM allergens exceeding 2 microg/g of dust may be regarded as a risk level possibly affecting respiratory health in early childhood. MATERIALS AND METHODS: House-dust samples were collected in 275 dwellings from mattresses, children's bedrooms and kitchen floors. In the laboratory, dust samples were analyzed for Der f 1 and Der p 1 using monoclonal antibody enzyme-linked immunosorbent assays (ELISA). At the time of the house-dust collection, mothers were interviewed on the household characteristics and their children's respiratory health. Respiratory outcome variables included wheezing or whistling in the chest irrespective of respiratory infections. The number of the wheezing episodes and their duration in days over the last 6 months were recorded in the questionnaire. In the multivariate Poisson regression analysis on the association between the occurrence of wheezing and exposure, a set of potential confounders, such as child's gender, maternal education, maternal allergy, older siblings, presence of moulds, house dampness, and environmental tobacco smoke (ETS) was taken into account. RESULTS: The adjusted incidence rate ratios (IRR) of wheezing ascribed to a higher HDM level (> 2.0 microg/g dust) were 1.84 (95% CI: 1.45-2.34) for duration of wheezing and 1.56 (95% CI: 0.88-2.75) for episodes. Of the confounders taken into consideration, the presence of moulds had the strongest impact on the risk of wheezing (IRR = 4.24; 95% CI: 3.08-5.84). CONCLUSION: The data support the view that exposure to a higher level of HDM allergens increases the burden of respiratory diseases in the early childhood and the effect is independent of maternal atopy, ETS, and moulds in homes. SN - 1232-1087 UR - https://www.unboundmedicine.com/medline/citation/17638678/Risk_of_wheezing_associated_with_house_dust_mite_allergens_and_indoor_air_quality_among_three_year_old_children__Kraków_inner_city_study_ L2 - https://medlineplus.gov/indoorairpollution.html DB - PRIME DP - Unbound Medicine ER -