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Grooming, scratching and feeding: role of response competition in acute anorectic response to rimonabant in male rats.
Psychopharmacology (Berl). 2007 Nov; 195(1):27-39.P

Abstract

RATIONALE

Although the CB1 receptor antagonist/inverse agonist rimonabant acutely suppresses food intake in rodents, the behavioural specificity of this effect remains unclear.

OBJECTIVES

To profile the behavioural effects of rimonabant in a free-feeding context.

MATERIALS AND METHODS

Videoanalysis was employed to characterise the effects of acute rimonabant (1.5 and 3.0 mg/kg, IP) on the behaviour of non-deprived male rats exposed to palatable mash. Data were also collected on post-treatment weight gain, and, as prolonged appetite suppression has been found after single dosing with compounds of this series, rats were reassessed (drug-free) for food intake 7 days after initial testing.

RESULTS

Both doses of rimonabant not only decreased mash consumption (44-55%) but also reduced 24-h weight gain. Although videoanalysis confirmed the inhibitory effects of rimonabant on feeding behaviour, it also revealed concurrent reductions in locomotion, rearing and sniffing as well as substantial (up to tenfold) and dose-dependent increases in grooming and scratching. Timecourse analyses further revealed that rimonabant dose-dependently induced frequent episodes of atypical scratching that waned over the test but which were succeeded by prolonged and behaviourally disruptive grooming. Finally, as groups did not differ in mash consumption on retest, any prolonged anorectic effect of acute rimonabant dissipates within 7 days of treatment.

CONCLUSIONS

The anorectic response to rimonabant in male rats would appear to be due largely to response competition. This parsimonious conclusion is supported by the less profound (although still significant) increases in scratching and grooming observed in rats treated with a sub-anorectic dose (0.5 mg/kg) of the compound.

Authors+Show Affiliations

Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17639351

Citation

Tallett, A J., et al. "Grooming, Scratching and Feeding: Role of Response Competition in Acute Anorectic Response to Rimonabant in Male Rats." Psychopharmacology, vol. 195, no. 1, 2007, pp. 27-39.
Tallett AJ, Blundell JE, Rodgers RJ. Grooming, scratching and feeding: role of response competition in acute anorectic response to rimonabant in male rats. Psychopharmacology (Berl). 2007;195(1):27-39.
Tallett, A. J., Blundell, J. E., & Rodgers, R. J. (2007). Grooming, scratching and feeding: role of response competition in acute anorectic response to rimonabant in male rats. Psychopharmacology, 195(1), 27-39.
Tallett AJ, Blundell JE, Rodgers RJ. Grooming, Scratching and Feeding: Role of Response Competition in Acute Anorectic Response to Rimonabant in Male Rats. Psychopharmacology (Berl). 2007;195(1):27-39. PubMed PMID: 17639351.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Grooming, scratching and feeding: role of response competition in acute anorectic response to rimonabant in male rats. AU - Tallett,A J, AU - Blundell,J E, AU - Rodgers,R J, Y1 - 2007/07/19/ PY - 2007/03/23/received PY - 2007/06/24/accepted PY - 2007/7/20/pubmed PY - 2008/3/18/medline PY - 2007/7/20/entrez SP - 27 EP - 39 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 195 IS - 1 N2 - RATIONALE: Although the CB1 receptor antagonist/inverse agonist rimonabant acutely suppresses food intake in rodents, the behavioural specificity of this effect remains unclear. OBJECTIVES: To profile the behavioural effects of rimonabant in a free-feeding context. MATERIALS AND METHODS: Videoanalysis was employed to characterise the effects of acute rimonabant (1.5 and 3.0 mg/kg, IP) on the behaviour of non-deprived male rats exposed to palatable mash. Data were also collected on post-treatment weight gain, and, as prolonged appetite suppression has been found after single dosing with compounds of this series, rats were reassessed (drug-free) for food intake 7 days after initial testing. RESULTS: Both doses of rimonabant not only decreased mash consumption (44-55%) but also reduced 24-h weight gain. Although videoanalysis confirmed the inhibitory effects of rimonabant on feeding behaviour, it also revealed concurrent reductions in locomotion, rearing and sniffing as well as substantial (up to tenfold) and dose-dependent increases in grooming and scratching. Timecourse analyses further revealed that rimonabant dose-dependently induced frequent episodes of atypical scratching that waned over the test but which were succeeded by prolonged and behaviourally disruptive grooming. Finally, as groups did not differ in mash consumption on retest, any prolonged anorectic effect of acute rimonabant dissipates within 7 days of treatment. CONCLUSIONS: The anorectic response to rimonabant in male rats would appear to be due largely to response competition. This parsimonious conclusion is supported by the less profound (although still significant) increases in scratching and grooming observed in rats treated with a sub-anorectic dose (0.5 mg/kg) of the compound. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/17639351/Grooming_scratching_and_feeding:_role_of_response_competition_in_acute_anorectic_response_to_rimonabant_in_male_rats_ L2 - https://dx.doi.org/10.1007/s00213-007-0880-2 DB - PRIME DP - Unbound Medicine ER -