Tags

Type your tag names separated by a space and hit enter

Gastric cancer susceptibility is not linked to pro-and anti-inflammatory cytokine gene polymorphisms in whites: a Nationwide Multicenter Study in Spain.
Am J Gastroenterol. 2007 Sep; 102(9):1878-92.AJ

Abstract

BACKGROUND AND AIMS

Recent studies have reported an association between cytokine gene polymorphisms and GC risk. However, results are inconsistent among studies from different geographic regions and ethnic groups. Our goal was to evaluate the influence of Helicobacter pylori (H. pylori) infection and host genetic factors on GC susceptibility in a population of Spanish white GC patients.

METHODS

DNA from 404 unrelated patients with GC and 404 sex- and age-matched healthy controls was typed for several functional polymorphisms in pro- (IL-1B, TNFA, LTA, IL-12p40) and anti-inflammatory (IL-4, IL-1RN, IL-10, TGFB1) genes by PCR, RFLP, and TaqMan assays. H. pylori infection and CagA/VacA antibody status were also determined by western blot serology.

RESULTS

Logistic regression analysis identified H. pylori infection with cagA strains (OR 2.54, 95% CI 1.77-3.66), smoking habit (OR 1.91, 95% CI 1.25-2.93), and positive family history of GC (OR 3.67, 95% CI 2.01-6.71) as independent risk factors for GC. None of the cytokine gene polymorphisms analyzed in this study were associated with susceptibility to GC development, whether GC patients were analyzed as a group or categorized according to anatomic location or histological subtype. Some simultaneous combinations of proinflammatory genotypes reportedly associated with greater GC risk yielded no significant differences between patients and controls.

CONCLUSIONS

Our results show that, at least in some white populations, the contribution of the cytokine gene polymorphisms evaluated in this study (IL-1B, IL-1RN, IL-12p40, LTA, IL-10, IL-4, and TGF-B1) to GC susceptibility may be less relevant than previously reported.

Authors+Show Affiliations

Instituto Aragonés de Ciencias de la Salud, Zaragoza, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17640324

Citation

García-González, María Asunción, et al. "Gastric Cancer Susceptibility Is Not Linked to Pro-and Anti-inflammatory Cytokine Gene Polymorphisms in Whites: a Nationwide Multicenter Study in Spain." The American Journal of Gastroenterology, vol. 102, no. 9, 2007, pp. 1878-92.
García-González MA, Lanas A, Quintero E, et al. Gastric cancer susceptibility is not linked to pro-and anti-inflammatory cytokine gene polymorphisms in whites: a Nationwide Multicenter Study in Spain. Am J Gastroenterol. 2007;102(9):1878-92.
García-González, M. A., Lanas, A., Quintero, E., Nicolás, D., Parra-Blanco, A., Strunk, M., Benito, R., Angel Simón, M., Santolaria, S., Sopeña, F., Piazuelo, E., Jiménez, P., Pascual, C., Mas, E., Irún, P., Espinel, J., Campo, R., Manzano, M., Geijo, F., ... Zaballa, M. (2007). Gastric cancer susceptibility is not linked to pro-and anti-inflammatory cytokine gene polymorphisms in whites: a Nationwide Multicenter Study in Spain. The American Journal of Gastroenterology, 102(9), 1878-92.
García-González MA, et al. Gastric Cancer Susceptibility Is Not Linked to Pro-and Anti-inflammatory Cytokine Gene Polymorphisms in Whites: a Nationwide Multicenter Study in Spain. Am J Gastroenterol. 2007;102(9):1878-92. PubMed PMID: 17640324.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastric cancer susceptibility is not linked to pro-and anti-inflammatory cytokine gene polymorphisms in whites: a Nationwide Multicenter Study in Spain. AU - García-González,María Asunción, AU - Lanas,Angel, AU - Quintero,Enrique, AU - Nicolás,David, AU - Parra-Blanco,Adolfo, AU - Strunk,Mark, AU - Benito,Rafael, AU - Angel Simón,Miguel, AU - Santolaria,Santos, AU - Sopeña,Federico, AU - Piazuelo,Elena, AU - Jiménez,Pilar, AU - Pascual,Cristina, AU - Mas,Eva, AU - Irún,Pilar, AU - Espinel,Jesús, AU - Campo,Rafael, AU - Manzano,Marisa, AU - Geijo,Fernando, AU - Pellisé,Maria, AU - González-Huix,Ferrán, AU - Nieto,Miguel, AU - Espinós,Jorge, AU - Titó,Llúcia, AU - Bujanda,Luis, AU - Zaballa,Manuel, AU - ,, Y1 - 2007/07/19/ PY - 2007/7/21/pubmed PY - 2007/10/31/medline PY - 2007/7/21/entrez SP - 1878 EP - 92 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 102 IS - 9 N2 - BACKGROUND AND AIMS: Recent studies have reported an association between cytokine gene polymorphisms and GC risk. However, results are inconsistent among studies from different geographic regions and ethnic groups. Our goal was to evaluate the influence of Helicobacter pylori (H. pylori) infection and host genetic factors on GC susceptibility in a population of Spanish white GC patients. METHODS: DNA from 404 unrelated patients with GC and 404 sex- and age-matched healthy controls was typed for several functional polymorphisms in pro- (IL-1B, TNFA, LTA, IL-12p40) and anti-inflammatory (IL-4, IL-1RN, IL-10, TGFB1) genes by PCR, RFLP, and TaqMan assays. H. pylori infection and CagA/VacA antibody status were also determined by western blot serology. RESULTS: Logistic regression analysis identified H. pylori infection with cagA strains (OR 2.54, 95% CI 1.77-3.66), smoking habit (OR 1.91, 95% CI 1.25-2.93), and positive family history of GC (OR 3.67, 95% CI 2.01-6.71) as independent risk factors for GC. None of the cytokine gene polymorphisms analyzed in this study were associated with susceptibility to GC development, whether GC patients were analyzed as a group or categorized according to anatomic location or histological subtype. Some simultaneous combinations of proinflammatory genotypes reportedly associated with greater GC risk yielded no significant differences between patients and controls. CONCLUSIONS: Our results show that, at least in some white populations, the contribution of the cytokine gene polymorphisms evaluated in this study (IL-1B, IL-1RN, IL-12p40, LTA, IL-10, IL-4, and TGF-B1) to GC susceptibility may be less relevant than previously reported. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/17640324/Gastric_cancer_susceptibility_is_not_linked_to_pro_and_anti_inflammatory_cytokine_gene_polymorphisms_in_whites:_a_Nationwide_Multicenter_Study_in_Spain_ L2 - https://Insights.ovid.com/pubmed?pmid=17640324 DB - PRIME DP - Unbound Medicine ER -