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The association between isoflavone and lower urinary tract symptoms in elderly men.
Br J Nutr. 2007 Dec; 98(6):1237-42.BJ

Abstract

The objective of the present study is to explore the association between lower urinary tract symptoms (LUTS) and dietary isoflavone in elderly men. In a large prospective cohort of 2000 Chinese men, the association between dietary isoflavone and LUTS were studied using standardized structured questionnaires. Dietary intake was assessed by a modified version of the Block FFQ. LUTS were assessed by the Chinese version of the International Prostatic Symptoms Score. Demographic, lifestyle and other medical information were also collected and were adjusted for in the analysis. After excluding 299 men with history of bladder surgery, bladder or prostate cancer or who were current users of medication for urinary problems, the association between LUTS and dietary isoflavone was explored. A total of 96.2 % of subjects reported some consumption of genistein, glycitein or daidzein. In ordinal multinominal logistic regression, subjects with dietary total isoflavone of more than 5.1 mg were significantly less likely to suffer from more severe LUTS (dietary intake from 5.1 to 9.5 mg: OR 0.59; 95 % CI 0.44, 0.80; from 9.6 to 14.3 mg: OR 0.81; 95 % CI 0.61, 1.09; from 14.4 to 21.7 mg: OR 0.68; 95 % CI 0.51, 0.92; 21.8 mg and above: OR 0.73; 95 % CI 0.54, 0.98) after adjustment for covariates. In this cross-sectional study, we showed a strong inverse association between dietary intake of isoflavone and the risk of LUTS.

Authors+Show Affiliations

Department of Community and Family Medicine, School of Public Health, Prince of Wales Hospital, Shatin, N.T., Hong Kong. yeungshanwong@cuhk.edu.hkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17640419

Citation

Wong, Samuel Y S., et al. "The Association Between Isoflavone and Lower Urinary Tract Symptoms in Elderly Men." The British Journal of Nutrition, vol. 98, no. 6, 2007, pp. 1237-42.
Wong SY, Lau WW, Leung PC, et al. The association between isoflavone and lower urinary tract symptoms in elderly men. Br J Nutr. 2007;98(6):1237-42.
Wong, S. Y., Lau, W. W., Leung, P. C., Leung, J. C., & Woo, J. (2007). The association between isoflavone and lower urinary tract symptoms in elderly men. The British Journal of Nutrition, 98(6), 1237-42.
Wong SY, et al. The Association Between Isoflavone and Lower Urinary Tract Symptoms in Elderly Men. Br J Nutr. 2007;98(6):1237-42. PubMed PMID: 17640419.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between isoflavone and lower urinary tract symptoms in elderly men. AU - Wong,Samuel Y S, AU - Lau,Winny W Y, AU - Leung,Ping C, AU - Leung,Jason C S, AU - Woo,Jean, Y1 - 2007/07/19/ PY - 2007/7/21/pubmed PY - 2008/3/14/medline PY - 2007/7/21/entrez SP - 1237 EP - 42 JF - The British journal of nutrition JO - Br J Nutr VL - 98 IS - 6 N2 - The objective of the present study is to explore the association between lower urinary tract symptoms (LUTS) and dietary isoflavone in elderly men. In a large prospective cohort of 2000 Chinese men, the association between dietary isoflavone and LUTS were studied using standardized structured questionnaires. Dietary intake was assessed by a modified version of the Block FFQ. LUTS were assessed by the Chinese version of the International Prostatic Symptoms Score. Demographic, lifestyle and other medical information were also collected and were adjusted for in the analysis. After excluding 299 men with history of bladder surgery, bladder or prostate cancer or who were current users of medication for urinary problems, the association between LUTS and dietary isoflavone was explored. A total of 96.2 % of subjects reported some consumption of genistein, glycitein or daidzein. In ordinal multinominal logistic regression, subjects with dietary total isoflavone of more than 5.1 mg were significantly less likely to suffer from more severe LUTS (dietary intake from 5.1 to 9.5 mg: OR 0.59; 95 % CI 0.44, 0.80; from 9.6 to 14.3 mg: OR 0.81; 95 % CI 0.61, 1.09; from 14.4 to 21.7 mg: OR 0.68; 95 % CI 0.51, 0.92; 21.8 mg and above: OR 0.73; 95 % CI 0.54, 0.98) after adjustment for covariates. In this cross-sectional study, we showed a strong inverse association between dietary intake of isoflavone and the risk of LUTS. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/17640419/The_association_between_isoflavone_and_lower_urinary_tract_symptoms_in_elderly_men_ L2 - https://www.cambridge.org/core/product/identifier/S0007114507787433/type/journal_article DB - PRIME DP - Unbound Medicine ER -