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COMT Val158Met moderation of stress-induced psychosis.
Psychol Med. 2007 Nov; 37(11):1651-6.PM

Abstract

BACKGROUND

Exposure to stressful life events increases the risk of developing a psychotic disorder. Moreover, increased reactivity to stress seems to represent part of the vulnerability for psychosis. This study aimed to investigate whether a functional polymorphism in the catechol-O-methyltransferase (COMT Val(158)Met) gene moderates the psychosis-inducing effects of stress.

METHOD

A semi-experimental stress exposure paradigm was used in a sample of 306 genotyped young men (aged 19-24 years), in whom measures of psychotic symptoms were obtained at recruitment in the Greek army (exposed condition) and again after 18 months of military training (unexposed condition).

RESULTS

Stress exposure at army induction was associated with an increased level of psychotic symptoms. In addition, carriers of the COMT Val(158)Met Val allele were more susceptible to the effect of stress on the psychosis outcome than those with the Met/Met genotype (test for interaction: chi2 = 5.02, df = 1, p = 0.025).

CONCLUSION

The COMT Val(158)Met genotype may moderate the effect of stress on psychotic symptoms.

Authors+Show Affiliations

Division of Psychological Medicine, Institute of Psychiatry, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17640440

Citation

Stefanis, Nicholas C., et al. "COMT Val158Met Moderation of Stress-induced Psychosis." Psychological Medicine, vol. 37, no. 11, 2007, pp. 1651-6.
Stefanis NC, Henquet C, Avramopoulos D, et al. COMT Val158Met moderation of stress-induced psychosis. Psychol Med. 2007;37(11):1651-6.
Stefanis, N. C., Henquet, C., Avramopoulos, D., Smyrnis, N., Evdokimidis, I., Myin-Germeys, I., Stefanis, C. N., & Van Os, J. (2007). COMT Val158Met moderation of stress-induced psychosis. Psychological Medicine, 37(11), 1651-6.
Stefanis NC, et al. COMT Val158Met Moderation of Stress-induced Psychosis. Psychol Med. 2007;37(11):1651-6. PubMed PMID: 17640440.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - COMT Val158Met moderation of stress-induced psychosis. AU - Stefanis,Nicholas C, AU - Henquet,Cécile, AU - Avramopoulos,Dimitrios, AU - Smyrnis,Nikolaos, AU - Evdokimidis,Ioannis, AU - Myin-Germeys,Inez, AU - Stefanis,Costas N, AU - Van Os,Jim, Y1 - 2007/07/20/ PY - 2007/7/21/pubmed PY - 2008/3/1/medline PY - 2007/7/21/entrez SP - 1651 EP - 6 JF - Psychological medicine JO - Psychol Med VL - 37 IS - 11 N2 - BACKGROUND: Exposure to stressful life events increases the risk of developing a psychotic disorder. Moreover, increased reactivity to stress seems to represent part of the vulnerability for psychosis. This study aimed to investigate whether a functional polymorphism in the catechol-O-methyltransferase (COMT Val(158)Met) gene moderates the psychosis-inducing effects of stress. METHOD: A semi-experimental stress exposure paradigm was used in a sample of 306 genotyped young men (aged 19-24 years), in whom measures of psychotic symptoms were obtained at recruitment in the Greek army (exposed condition) and again after 18 months of military training (unexposed condition). RESULTS: Stress exposure at army induction was associated with an increased level of psychotic symptoms. In addition, carriers of the COMT Val(158)Met Val allele were more susceptible to the effect of stress on the psychosis outcome than those with the Met/Met genotype (test for interaction: chi2 = 5.02, df = 1, p = 0.025). CONCLUSION: The COMT Val(158)Met genotype may moderate the effect of stress on psychotic symptoms. SN - 0033-2917 UR - https://www.unboundmedicine.com/medline/citation/17640440/COMT_Val158Met_moderation_of_stress_induced_psychosis_ L2 - https://www.cambridge.org/core/product/identifier/S0033291707001080/type/journal_article DB - PRIME DP - Unbound Medicine ER -