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Roadside oral fluid testing: comparison of the results of drugwipe 5 and drugwipe benzodiazepines on-site tests with laboratory confirmation results of oral fluid and whole blood.
Forensic Sci Int. 2008 Mar 05; 175(2-3):140-8.FS

Abstract

Drugged drivers pose a serious threat to other people in traffic as well as to themselves. Reliable oral fluid screening devices for on-site screening of drugged drivers would be both a useful and convenient means for traffic control. In this study we evaluated the appropriateness of Drugwipe 5 and Drugwipe Benzodiazepines oral fluid on-site tests for roadside drug screening. Drivers suspected of driving under the influence of drugs were screened with the Drugwipe tests. Oral fluid and whole blood samples were collected from the drivers and tested for amphetamine-type stimulant drugs, cannabis, opiates, cocaine and benzodiazepines by immunological methods, GC and GC-MS. The performance evaluations of the tests were made by comparing the results of the Drugwipe tests with laboratory GC-MS confirmation results of oral fluid or whole blood. In addition to the performance evaluations of the Drugwipe tests based on laboratory results, a questionnaire on the practical aspects of the tests was written for the police officers who performed the tests. The aim of the questionnaire was to obtain user comments on the practicality of the tests as well as the advantages and weak points of the tests. The results of the performance evaluations were: for oral fluid (sensitivity; specificity; accuracy) amphetamines (95.5%; 92.9%; 95.3%), cannabis (52.2%; 91.2%; 85.1%), cocaine (50.0%; 99.3%; 98.6%), opiates (100%; 95.8%; 95.9%), benzodiazepines (74.4%; 84.2%; 79.2%) and for whole blood accordingly, amphetamines (97.7%; 86.7%; 95.9%), cannabis (68.3%; 87.9%; 84.9%), cocaine (50.0%; 98.5%; 97.7%), opiates (87.5%; 96.9%; 96.6%) and benzodiazepines (66.7%; 87.0%; 74.4%). Although the Drugwipe 5 successfully detected amphetamine-type stimulant drugs and the police officers were quite pleased with the current features of the Drugwipe tests, improvements must still be made regarding the detection of cannabis and benzodiazepines.

Authors+Show Affiliations

National Public Health Institute, Drug Research Unit, Mannerheimintie 166, FI-00300 Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17640837

Citation

Pehrsson, Anna, et al. "Roadside Oral Fluid Testing: Comparison of the Results of Drugwipe 5 and Drugwipe Benzodiazepines On-site Tests With Laboratory Confirmation Results of Oral Fluid and Whole Blood." Forensic Science International, vol. 175, no. 2-3, 2008, pp. 140-8.
Pehrsson A, Gunnar T, Engblom C, et al. Roadside oral fluid testing: comparison of the results of drugwipe 5 and drugwipe benzodiazepines on-site tests with laboratory confirmation results of oral fluid and whole blood. Forensic Sci Int. 2008;175(2-3):140-8.
Pehrsson, A., Gunnar, T., Engblom, C., Seppä, H., Jama, A., & Lillsunde, P. (2008). Roadside oral fluid testing: comparison of the results of drugwipe 5 and drugwipe benzodiazepines on-site tests with laboratory confirmation results of oral fluid and whole blood. Forensic Science International, 175(2-3), 140-8.
Pehrsson A, et al. Roadside Oral Fluid Testing: Comparison of the Results of Drugwipe 5 and Drugwipe Benzodiazepines On-site Tests With Laboratory Confirmation Results of Oral Fluid and Whole Blood. Forensic Sci Int. 2008 Mar 5;175(2-3):140-8. PubMed PMID: 17640837.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Roadside oral fluid testing: comparison of the results of drugwipe 5 and drugwipe benzodiazepines on-site tests with laboratory confirmation results of oral fluid and whole blood. AU - Pehrsson,Anna, AU - Gunnar,Teemu, AU - Engblom,Charlotta, AU - Seppä,Heikki, AU - Jama,Ahlam, AU - Lillsunde,Pirjo, Y1 - 2007/07/20/ PY - 2006/09/19/received PY - 2007/05/24/revised PY - 2007/05/31/accepted PY - 2007/7/21/pubmed PY - 2008/4/11/medline PY - 2007/7/21/entrez SP - 140 EP - 8 JF - Forensic science international JO - Forensic Sci. Int. VL - 175 IS - 2-3 N2 - Drugged drivers pose a serious threat to other people in traffic as well as to themselves. Reliable oral fluid screening devices for on-site screening of drugged drivers would be both a useful and convenient means for traffic control. In this study we evaluated the appropriateness of Drugwipe 5 and Drugwipe Benzodiazepines oral fluid on-site tests for roadside drug screening. Drivers suspected of driving under the influence of drugs were screened with the Drugwipe tests. Oral fluid and whole blood samples were collected from the drivers and tested for amphetamine-type stimulant drugs, cannabis, opiates, cocaine and benzodiazepines by immunological methods, GC and GC-MS. The performance evaluations of the tests were made by comparing the results of the Drugwipe tests with laboratory GC-MS confirmation results of oral fluid or whole blood. In addition to the performance evaluations of the Drugwipe tests based on laboratory results, a questionnaire on the practical aspects of the tests was written for the police officers who performed the tests. The aim of the questionnaire was to obtain user comments on the practicality of the tests as well as the advantages and weak points of the tests. The results of the performance evaluations were: for oral fluid (sensitivity; specificity; accuracy) amphetamines (95.5%; 92.9%; 95.3%), cannabis (52.2%; 91.2%; 85.1%), cocaine (50.0%; 99.3%; 98.6%), opiates (100%; 95.8%; 95.9%), benzodiazepines (74.4%; 84.2%; 79.2%) and for whole blood accordingly, amphetamines (97.7%; 86.7%; 95.9%), cannabis (68.3%; 87.9%; 84.9%), cocaine (50.0%; 98.5%; 97.7%), opiates (87.5%; 96.9%; 96.6%) and benzodiazepines (66.7%; 87.0%; 74.4%). Although the Drugwipe 5 successfully detected amphetamine-type stimulant drugs and the police officers were quite pleased with the current features of the Drugwipe tests, improvements must still be made regarding the detection of cannabis and benzodiazepines. SN - 1872-6283 UR - https://www.unboundmedicine.com/medline/citation/17640837/Roadside_oral_fluid_testing:_comparison_of_the_results_of_drugwipe_5_and_drugwipe_benzodiazepines_on_site_tests_with_laboratory_confirmation_results_of_oral_fluid_and_whole_blood_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0379-0738(07)00574-9 DB - PRIME DP - Unbound Medicine ER -