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Single muscle fiber function with concurrent exercise or nutrition countermeasures during 60 days of bed rest in women.
J Appl Physiol (1985). 2007 Oct; 103(4):1242-50.JA

Abstract

There is limited information on skeletal muscle properties in women with unloading and countermeasure programs to protect the unloading-induced atrophy. The current investigation tested the hypothesis that a concurrent aerobic and resistance exercise training program would preserve size and contractile function of slow- and fast-twitch muscle fibers. A secondary objective was to test the hypothesis that a leucine-enriched high-protein diet would partially attenuate single fiber characteristics. Vastus lateralis muscle biopsies were obtained before and on day 59 of bed rest from a control (BR; n = 8), nutrition (BRN; n = 8), or exercise (BRE; n = 8) group. Single muscle fibers were studied for diameter, peak force (P(o)), contractile velocity, and power. Those in the BR group had a decrease (P < 0.05) in myosin heavy chain (MHC) I diameter (-14%), P(o) (-35%), and power (-42%) and MHC IIa diameter (-16%) and P(o) (-31%; P = 0.06) and an increase (P < 0.05) in MHC hybrid fibers. Changes in size and function of MHC I (-19 to -44%) and IIa (-21% to -30%) fibers and MHC distribution in BRN individuals were similar to results in the BR group. In BRE conditions, MHC I and IIa size and contractile function were preserved during bed rest. These data show that the concurrent exercise program preserved the myocellular profile of the vastus lateralis muscle during 60-day bed rest. To combat muscle atrophy and function with long-term unloading, the exercise prescription program used in this study should be considered as a viable training program for the upper leg muscles, whereas the nutritional intervention used cannot be recommended as a countermeasure for skeletal muscle.

Authors+Show Affiliations

Human Performance Laboratory, Ball State University, Muncie, IN 47306, USA. strappe@bsu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

17641219

Citation

Trappe, Scott, et al. "Single Muscle Fiber Function With Concurrent Exercise or Nutrition Countermeasures During 60 Days of Bed Rest in Women." Journal of Applied Physiology (Bethesda, Md. : 1985), vol. 103, no. 4, 2007, pp. 1242-50.
Trappe S, Creer A, Slivka D, et al. Single muscle fiber function with concurrent exercise or nutrition countermeasures during 60 days of bed rest in women. J Appl Physiol (1985). 2007;103(4):1242-50.
Trappe, S., Creer, A., Slivka, D., Minchev, K., & Trappe, T. (2007). Single muscle fiber function with concurrent exercise or nutrition countermeasures during 60 days of bed rest in women. Journal of Applied Physiology (Bethesda, Md. : 1985), 103(4), 1242-50.
Trappe S, et al. Single Muscle Fiber Function With Concurrent Exercise or Nutrition Countermeasures During 60 Days of Bed Rest in Women. J Appl Physiol (1985). 2007;103(4):1242-50. PubMed PMID: 17641219.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Single muscle fiber function with concurrent exercise or nutrition countermeasures during 60 days of bed rest in women. AU - Trappe,Scott, AU - Creer,Andrew, AU - Slivka,Dustin, AU - Minchev,Kiril, AU - Trappe,Todd, Y1 - 2007/07/19/ PY - 2007/7/21/pubmed PY - 2007/12/7/medline PY - 2007/7/21/entrez SP - 1242 EP - 50 JF - Journal of applied physiology (Bethesda, Md. : 1985) JO - J Appl Physiol (1985) VL - 103 IS - 4 N2 - There is limited information on skeletal muscle properties in women with unloading and countermeasure programs to protect the unloading-induced atrophy. The current investigation tested the hypothesis that a concurrent aerobic and resistance exercise training program would preserve size and contractile function of slow- and fast-twitch muscle fibers. A secondary objective was to test the hypothesis that a leucine-enriched high-protein diet would partially attenuate single fiber characteristics. Vastus lateralis muscle biopsies were obtained before and on day 59 of bed rest from a control (BR; n = 8), nutrition (BRN; n = 8), or exercise (BRE; n = 8) group. Single muscle fibers were studied for diameter, peak force (P(o)), contractile velocity, and power. Those in the BR group had a decrease (P < 0.05) in myosin heavy chain (MHC) I diameter (-14%), P(o) (-35%), and power (-42%) and MHC IIa diameter (-16%) and P(o) (-31%; P = 0.06) and an increase (P < 0.05) in MHC hybrid fibers. Changes in size and function of MHC I (-19 to -44%) and IIa (-21% to -30%) fibers and MHC distribution in BRN individuals were similar to results in the BR group. In BRE conditions, MHC I and IIa size and contractile function were preserved during bed rest. These data show that the concurrent exercise program preserved the myocellular profile of the vastus lateralis muscle during 60-day bed rest. To combat muscle atrophy and function with long-term unloading, the exercise prescription program used in this study should be considered as a viable training program for the upper leg muscles, whereas the nutritional intervention used cannot be recommended as a countermeasure for skeletal muscle. SN - 8750-7587 UR - https://www.unboundmedicine.com/medline/citation/17641219/Single_muscle_fiber_function_with_concurrent_exercise_or_nutrition_countermeasures_during_60_days_of_bed_rest_in_women_ L2 - https://journals.physiology.org/doi/10.1152/japplphysiol.00560.2007?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -