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Elevated plasma homocysteine concentration in elderly patients with mental illness is mainly related to the presence of vascular disease and not the diagnosis.
Dement Geriatr Cogn Disord. 2007; 24(3):162-8.DG

Abstract

BACKGROUND

Plasma total homocysteine (tHcy) is often elevated in patients with mental illness. Since patients with mental illness and vascular disease exhibit a higher plasma tHcy concentration than patients without vascular disease, it is possible that elevated plasma tHcy in mental illness is mainly due to concomitant vascular disease.

METHODS

We have investigated plasma tHcy, cobalamin/folate status, renal function and the presence of vascular disease in patients with vascular dementia (VaD, n = 501), Alzheimer's disease (AD, n = 300), depression (n = 259) and in healthy subjects (n = 144) stratified according to age (below and above 75 years).

RESULTS

Plasma tHcy concentration showed the highest increase in patients with VaD compared to patients with AD or depression. After the exclusion of patients with cobalamin/folate deficiencies and increased serum creatinine, patients with AD or depression above 75 years with vascular disease showed a similar elevation of plasma tHcy concentration as patients with VaD. Furthermore, patients with AD and depression without vascular disease showed a similar plasma tHcy concentration to healthy subjects.

CONCLUSION

The findings imply that elevated plasma tHcy concentration in elderly patients with mental illness is mainly associated with the presence of vascular disease and is not related to the specific psychogeriatric diagnosis.

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Authors+Show Affiliations

Nilsson K
Department of Psychogeriatrics, Clinical Science, Division of Clinical Chemistry, Lund University Hospital, Lund, Sweden.
Gustafson L
No affiliation info available
Hultberg B
No affiliation info available

MeSH

AgedAged, 80 and overAgingCreatinineFemaleFolic AcidFolic Acid DeficiencyHomocysteineHumansKidney Function TestsMaleMental DisordersPsychiatric Status Rating ScalesVascular DiseasesVitamin B 12Vitamin B 12 Deficiency

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17641526

Citation

Nilsson, Karin, et al. "Elevated Plasma Homocysteine Concentration in Elderly Patients With Mental Illness Is Mainly Related to the Presence of Vascular Disease and Not the Diagnosis." Dementia and Geriatric Cognitive Disorders, vol. 24, no. 3, 2007, pp. 162-8.
Nilsson K, Gustafson L, Hultberg B. Elevated plasma homocysteine concentration in elderly patients with mental illness is mainly related to the presence of vascular disease and not the diagnosis. Dement Geriatr Cogn Disord. 2007;24(3):162-8.
Nilsson, K., Gustafson, L., & Hultberg, B. (2007). Elevated plasma homocysteine concentration in elderly patients with mental illness is mainly related to the presence of vascular disease and not the diagnosis. Dementia and Geriatric Cognitive Disorders, 24(3), 162-8.
Nilsson K, Gustafson L, Hultberg B. Elevated Plasma Homocysteine Concentration in Elderly Patients With Mental Illness Is Mainly Related to the Presence of Vascular Disease and Not the Diagnosis. Dement Geriatr Cogn Disord. 2007;24(3):162-8. PubMed PMID: 17641526.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated plasma homocysteine concentration in elderly patients with mental illness is mainly related to the presence of vascular disease and not the diagnosis. AU - Nilsson,Karin, AU - Gustafson,Lars, AU - Hultberg,Björn, Y1 - 2007/07/17/ PY - 2007/05/08/accepted PY - 2007/7/21/pubmed PY - 2007/10/30/medline PY - 2007/7/21/entrez SP - 162 EP - 8 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 24 IS - 3 N2 - BACKGROUND: Plasma total homocysteine (tHcy) is often elevated in patients with mental illness. Since patients with mental illness and vascular disease exhibit a higher plasma tHcy concentration than patients without vascular disease, it is possible that elevated plasma tHcy in mental illness is mainly due to concomitant vascular disease. METHODS: We have investigated plasma tHcy, cobalamin/folate status, renal function and the presence of vascular disease in patients with vascular dementia (VaD, n = 501), Alzheimer's disease (AD, n = 300), depression (n = 259) and in healthy subjects (n = 144) stratified according to age (below and above 75 years). RESULTS: Plasma tHcy concentration showed the highest increase in patients with VaD compared to patients with AD or depression. After the exclusion of patients with cobalamin/folate deficiencies and increased serum creatinine, patients with AD or depression above 75 years with vascular disease showed a similar elevation of plasma tHcy concentration as patients with VaD. Furthermore, patients with AD and depression without vascular disease showed a similar plasma tHcy concentration to healthy subjects. CONCLUSION: The findings imply that elevated plasma tHcy concentration in elderly patients with mental illness is mainly associated with the presence of vascular disease and is not related to the specific psychogeriatric diagnosis. SN - 1420-8008 UR - https://www.unboundmedicine.com/medline/citation/17641526/Elevated_plasma_homocysteine_concentration_in_elderly_patients_with_mental_illness_is_mainly_related_to_the_presence_of_vascular_disease_and_not_the_diagnosis_ L2 - https://www.karger.com?DOI=10.1159/000105562 DB - PRIME DP - Unbound Medicine ER -