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Further studies on antioxidant potential and protection of pancreatic beta-cells by Embelia ribes in experimental diabetes.
Exp Diabetes Res. 2007; 2007:15803.ED

Abstract

This study was designed to examine the antioxidant defense by ethanolic extract of Embelia ribes on streptozotocin-(40 mg/kg, intravenously, single-injection) induced diabetes in Wistar rats. Forty days of oral feeding the extract (100 mg/kg and 200 mg/kg) to diabetic rats resulted in significant (P < .01) decrease in blood glucose, blood glycosylated haemoglobin, serum lactate dehydrogenase, creatine kinase, and increase in blood glutathione levels as compared to pathogenic diabetic rats. Further, the extract also significantly (P < .01) decreased the pancreatic thiobarbituric acid-reactive substances (TBARS) levels and significantly (P < .01) increased the superoxide dismutase, catalase, and glutathione levels as compared to above levels in pancreatic tissue of pathogenic diabetic rats. The islets were shrunken in diabetic rats in comparison to normal rats. In the drug-treated diabetic rats, there was expansion of islets. The results of test drug were comparable to gliclazide (25 mg/kg, daily), a standard antihyperglycemic agent. The study concludes that Embelia ribes enhances the antioxidant defense against reactive oxygen species produced under hyperglycemic condition and this protects beta-cells against loss, and exhibit antidiabetic property.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Pharmacy, Hamdard University, New Delhi 110062, India. uma_bora@hotmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17641739

Citation

Bhandari, Uma, et al. "Further Studies On Antioxidant Potential and Protection of Pancreatic Beta-cells By Embelia Ribes in Experimental Diabetes." Experimental Diabetes Research, vol. 2007, 2007, p. 15803.
Bhandari U, Jain N, Pillai KK. Further studies on antioxidant potential and protection of pancreatic beta-cells by Embelia ribes in experimental diabetes. Exp Diabetes Res. 2007;2007:15803.
Bhandari, U., Jain, N., & Pillai, K. K. (2007). Further studies on antioxidant potential and protection of pancreatic beta-cells by Embelia ribes in experimental diabetes. Experimental Diabetes Research, 2007, 15803.
Bhandari U, Jain N, Pillai KK. Further Studies On Antioxidant Potential and Protection of Pancreatic Beta-cells By Embelia Ribes in Experimental Diabetes. Exp Diabetes Res. 2007;2007:15803. PubMed PMID: 17641739.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Further studies on antioxidant potential and protection of pancreatic beta-cells by Embelia ribes in experimental diabetes. AU - Bhandari,Uma, AU - Jain,Neeti, AU - Pillai,K K, PY - 2006/07/14/received PY - 2007/01/10/revised PY - 2007/02/20/accepted PY - 2007/7/21/pubmed PY - 2008/2/21/medline PY - 2007/7/21/entrez SP - 15803 EP - 15803 JF - Experimental diabetes research JO - Exp Diabetes Res VL - 2007 N2 - This study was designed to examine the antioxidant defense by ethanolic extract of Embelia ribes on streptozotocin-(40 mg/kg, intravenously, single-injection) induced diabetes in Wistar rats. Forty days of oral feeding the extract (100 mg/kg and 200 mg/kg) to diabetic rats resulted in significant (P < .01) decrease in blood glucose, blood glycosylated haemoglobin, serum lactate dehydrogenase, creatine kinase, and increase in blood glutathione levels as compared to pathogenic diabetic rats. Further, the extract also significantly (P < .01) decreased the pancreatic thiobarbituric acid-reactive substances (TBARS) levels and significantly (P < .01) increased the superoxide dismutase, catalase, and glutathione levels as compared to above levels in pancreatic tissue of pathogenic diabetic rats. The islets were shrunken in diabetic rats in comparison to normal rats. In the drug-treated diabetic rats, there was expansion of islets. The results of test drug were comparable to gliclazide (25 mg/kg, daily), a standard antihyperglycemic agent. The study concludes that Embelia ribes enhances the antioxidant defense against reactive oxygen species produced under hyperglycemic condition and this protects beta-cells against loss, and exhibit antidiabetic property. SN - 1687-5303 UR - https://www.unboundmedicine.com/medline/citation/17641739/Further_studies_on_antioxidant_potential_and_protection_of_pancreatic_beta_cells_by_Embelia_ribes_in_experimental_diabetes_ L2 - https://doi.org/10.1155/2007/15803 DB - PRIME DP - Unbound Medicine ER -