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The GSTP1 gene is a susceptibility gene for childhood asthma and the GSTM1 gene is a modifier of the GSTP1 gene.
Int Arch Allergy Immunol. 2007; 144(4):275-86.IA

Abstract

BACKGROUND

Bronchial asthma is a chronic airway disorder characterized by bronchial inflammation. Oxidative stress is a key component of inflammation. Glutathione S-transferase P1 (GSTP1), the abundant isoform of glutathione S-transferases (GSTs) in lung epithelium, plays a key role in cellular protection against oxidative stress. Several studies have shown that the GSTP1 geneis involved in the pathogenesis of asthma and a gene-gene interaction may occur within the GST gene superfamily.

METHODS

We screened single-nucleotide polymorphisms (SNPs) at the GSTP1 locus and performed an association study in the Japanese population using two independent case-control groups (group 1: 391 pediatric patients with asthma, 462 adult patients with asthma, and 639 controls, and group 2: 115 pediatric patients with asthma and 184 controls). The effect of GSTM1 null/present genotype on the association between GSTP1 Ile105Val and asthma was also investigated.

RESULTS

We identified 20 SNPs at this locus and found this region consisted of one linkage disequilibrium block represented by four SNPs (tag SNPs). The association between the Ile105Val polymorphism in the GSTP1 gene and childhood asthma was significant in both groups (p = 0.047 in group 1, and p = 0.021 in group 2). This association was only significant in patients with GSTM1-positive genotype in both groups (group 1: GSTM1 present p = 0.013 and GSTM1 null p = 0.925, and group 2: GSTM1 present p = 0.015 and GSTM1 null p = 0.362).

CONCLUSIONS

These findings suggest that the GSTP1 gene is a childhood asthma susceptible gene, and the GSTM1 gene is a modifier gene of GSTP1 for the risk of childhood asthma in the Japanese population.

Authors+Show Affiliations

Department of Medical Genetics, Tohoku University School of Medicine, Sendai, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17643058

Citation

Kamada, Fumiaki, et al. "The GSTP1 Gene Is a Susceptibility Gene for Childhood Asthma and the GSTM1 Gene Is a Modifier of the GSTP1 Gene." International Archives of Allergy and Immunology, vol. 144, no. 4, 2007, pp. 275-86.
Kamada F, Mashimo Y, Inoue H, et al. The GSTP1 gene is a susceptibility gene for childhood asthma and the GSTM1 gene is a modifier of the GSTP1 gene. Int Arch Allergy Immunol. 2007;144(4):275-86.
Kamada, F., Mashimo, Y., Inoue, H., Shao, C., Hirota, T., Doi, S., Kameda, M., Fujiwara, H., Fujita, K., Enomoto, T., Sasaki, S., Endo, H., Takayanagi, R., Nakazawa, C., Morikawa, T., Morikawa, M., Miyabayashi, S., Chiba, Y., Tamura, G., ... Suzuki, Y. (2007). The GSTP1 gene is a susceptibility gene for childhood asthma and the GSTM1 gene is a modifier of the GSTP1 gene. International Archives of Allergy and Immunology, 144(4), 275-86.
Kamada F, et al. The GSTP1 Gene Is a Susceptibility Gene for Childhood Asthma and the GSTM1 Gene Is a Modifier of the GSTP1 Gene. Int Arch Allergy Immunol. 2007;144(4):275-86. PubMed PMID: 17643058.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The GSTP1 gene is a susceptibility gene for childhood asthma and the GSTM1 gene is a modifier of the GSTP1 gene. AU - Kamada,Fumiaki, AU - Mashimo,Yoichi, AU - Inoue,Hiroki, AU - Shao,Chenchen, AU - Hirota,Tomomitsu, AU - Doi,Satoru, AU - Kameda,Makoto, AU - Fujiwara,Hiroshi, AU - Fujita,Kimie, AU - Enomoto,Tadao, AU - Sasaki,Sei, AU - Endo,Hiroko, AU - Takayanagi,Reiko, AU - Nakazawa,Chifuyu, AU - Morikawa,Toshio, AU - Morikawa,Miki, AU - Miyabayashi,Shigeaki, AU - Chiba,Yasushi, AU - Tamura,Gen, AU - Shirakawa,Taro, AU - Matsubara,Yoichi, AU - Hata,Akira, AU - Tamari,Mayumi, AU - Suzuki,Yoichi, Y1 - 2007/07/20/ PY - 2006/10/06/received PY - 2007/04/11/accepted PY - 2007/7/24/pubmed PY - 2007/12/19/medline PY - 2007/7/24/entrez SP - 275 EP - 86 JF - International archives of allergy and immunology JO - Int Arch Allergy Immunol VL - 144 IS - 4 N2 - BACKGROUND: Bronchial asthma is a chronic airway disorder characterized by bronchial inflammation. Oxidative stress is a key component of inflammation. Glutathione S-transferase P1 (GSTP1), the abundant isoform of glutathione S-transferases (GSTs) in lung epithelium, plays a key role in cellular protection against oxidative stress. Several studies have shown that the GSTP1 geneis involved in the pathogenesis of asthma and a gene-gene interaction may occur within the GST gene superfamily. METHODS: We screened single-nucleotide polymorphisms (SNPs) at the GSTP1 locus and performed an association study in the Japanese population using two independent case-control groups (group 1: 391 pediatric patients with asthma, 462 adult patients with asthma, and 639 controls, and group 2: 115 pediatric patients with asthma and 184 controls). The effect of GSTM1 null/present genotype on the association between GSTP1 Ile105Val and asthma was also investigated. RESULTS: We identified 20 SNPs at this locus and found this region consisted of one linkage disequilibrium block represented by four SNPs (tag SNPs). The association between the Ile105Val polymorphism in the GSTP1 gene and childhood asthma was significant in both groups (p = 0.047 in group 1, and p = 0.021 in group 2). This association was only significant in patients with GSTM1-positive genotype in both groups (group 1: GSTM1 present p = 0.013 and GSTM1 null p = 0.925, and group 2: GSTM1 present p = 0.015 and GSTM1 null p = 0.362). CONCLUSIONS: These findings suggest that the GSTP1 gene is a childhood asthma susceptible gene, and the GSTM1 gene is a modifier gene of GSTP1 for the risk of childhood asthma in the Japanese population. SN - 1423-0097 UR - https://www.unboundmedicine.com/medline/citation/17643058/The_GSTP1_gene_is_a_susceptibility_gene_for_childhood_asthma_and_the_GSTM1_gene_is_a_modifier_of_the_GSTP1_gene_ L2 - https://www.karger.com?DOI=10.1159/000106316 DB - PRIME DP - Unbound Medicine ER -