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Cholecalciferol enhances the anticonvulsant effect of conventional antiepileptic drugs in the mouse model of maximal electroshock.
Eur J Pharmacol. 2007 Nov 14; 573(1-3):111-5.EJ

Abstract

The interactions between cholecalciferol, a precursor of the active form of Vitamin D(3), and conventional antiepileptic drugs (valproate, carbamazepine, phenytoin, and phenobarbital) were studied in the maximal electroshock test in mice. Vitamin D(3) applied i.p. at doses of 37.5 and 75 mug/kg, but not at 18.75 mug/kg, significantly raised the electroconvulsive threshold. Furthermore, cholecalciferol (at its highest subthreshold dose of 18.75 mug) potentiated the anticonvulsant activity of phenytoin and valproate. The action of carbamazepine and phenobarbital was also enhanced by Vitamin D(3), but when it was given at the higher dose of 37.5 mug/kg. Cholecalciferol, antiepileptic drugs, and their combinations did not produce significant adverse effects evaluated in the chimney test (motor coordination) and passive-avoidance task (long-term memory). Cholecalciferol did not significantly increase the brain concentrations of conventional antiepileptics, indicating a pharmacodynamic nature of revealed interactions. Our findings show that cholecalciferol may play an anticonvulsant role in the brain and can influence the efficacy of antiepileptic drugs, at least in experimental conditions.

Authors+Show Affiliations

Department of Pathophysiology, Medical University, Lublin, Poland. kinga.borowics@am.lublin.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17643415

Citation

Borowicz, Kinga K., et al. "Cholecalciferol Enhances the Anticonvulsant Effect of Conventional Antiepileptic Drugs in the Mouse Model of Maximal Electroshock." European Journal of Pharmacology, vol. 573, no. 1-3, 2007, pp. 111-5.
Borowicz KK, Morawska M, Furmanek-Karwowska K, et al. Cholecalciferol enhances the anticonvulsant effect of conventional antiepileptic drugs in the mouse model of maximal electroshock. Eur J Pharmacol. 2007;573(1-3):111-5.
Borowicz, K. K., Morawska, M., Furmanek-Karwowska, K., Luszczki, J. J., & Czuczwar, S. J. (2007). Cholecalciferol enhances the anticonvulsant effect of conventional antiepileptic drugs in the mouse model of maximal electroshock. European Journal of Pharmacology, 573(1-3), 111-5.
Borowicz KK, et al. Cholecalciferol Enhances the Anticonvulsant Effect of Conventional Antiepileptic Drugs in the Mouse Model of Maximal Electroshock. Eur J Pharmacol. 2007 Nov 14;573(1-3):111-5. PubMed PMID: 17643415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cholecalciferol enhances the anticonvulsant effect of conventional antiepileptic drugs in the mouse model of maximal electroshock. AU - Borowicz,Kinga K, AU - Morawska,Marta, AU - Furmanek-Karwowska,Kamila, AU - Luszczki,Jarogniew J, AU - Czuczwar,Stanislaw J, Y1 - 2007/07/10/ PY - 2007/04/16/received PY - 2007/06/20/revised PY - 2007/07/04/accepted PY - 2007/7/24/pubmed PY - 2008/3/14/medline PY - 2007/7/24/entrez SP - 111 EP - 5 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 573 IS - 1-3 N2 - The interactions between cholecalciferol, a precursor of the active form of Vitamin D(3), and conventional antiepileptic drugs (valproate, carbamazepine, phenytoin, and phenobarbital) were studied in the maximal electroshock test in mice. Vitamin D(3) applied i.p. at doses of 37.5 and 75 mug/kg, but not at 18.75 mug/kg, significantly raised the electroconvulsive threshold. Furthermore, cholecalciferol (at its highest subthreshold dose of 18.75 mug) potentiated the anticonvulsant activity of phenytoin and valproate. The action of carbamazepine and phenobarbital was also enhanced by Vitamin D(3), but when it was given at the higher dose of 37.5 mug/kg. Cholecalciferol, antiepileptic drugs, and their combinations did not produce significant adverse effects evaluated in the chimney test (motor coordination) and passive-avoidance task (long-term memory). Cholecalciferol did not significantly increase the brain concentrations of conventional antiepileptics, indicating a pharmacodynamic nature of revealed interactions. Our findings show that cholecalciferol may play an anticonvulsant role in the brain and can influence the efficacy of antiepileptic drugs, at least in experimental conditions. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/17643415/Cholecalciferol_enhances_the_anticonvulsant_effect_of_conventional_antiepileptic_drugs_in_the_mouse_model_of_maximal_electroshock_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(07)00777-7 DB - PRIME DP - Unbound Medicine ER -