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Skin manifestations of biotin deficiency.

Abstract

This article reviews current knowledge concerning the dermatologic manifestations of biotin deficiency. Biotin is a water-soluble vitamin that acts as an essential cofactor for four carboxylases, each of which catalyzes an essential step in intermediary metabolism. For example, acetyl-CoA carboxylase catalyzes the rate-limiting step in fatty acid elongation. In infants, children, and adults, deficiency of biotin causes alopecia and a characteristic scaly, erythematous dermatitis distributed around body orifices. The rash closely resembles that of zinc deficiency. Candida albicans often can be cultured from the skin lesions. Biotinidase deficiency, an inborn error, causes biotin deficiency, probably as a consequence of unpaired intestinal absorption, cellular salvage, and renal reclamation of biotin; biotinidase deficiency causes dermatologic manifestations similar to biotin deficiency. There is evidence that impaired fatty acid metabolism secondary to reduced activities of the biotin-dependent carboxylases (especially acetyl-CoA carboxylase) plays an etiologic role in the dermatologic manifestations of biotin deficiency. Candida infections secondary to impaired immune function might also contribute to the dermatitis of biotin deficiency.

Authors+Show Affiliations

Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City 52242.

Source

Seminars in dermatology 10:4 1991 Dec pg 296-302

MeSH

Adult
Biotin
Child
Humans
Infant
Metabolism, Inborn Errors
Skin Diseases

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

1764357

Citation

Mock, D M.. "Skin Manifestations of Biotin Deficiency." Seminars in Dermatology, vol. 10, no. 4, 1991, pp. 296-302.
Mock DM. Skin manifestations of biotin deficiency. Semin Dermatol. 1991;10(4):296-302.
Mock, D. M. (1991). Skin manifestations of biotin deficiency. Seminars in Dermatology, 10(4), pp. 296-302.
Mock DM. Skin Manifestations of Biotin Deficiency. Semin Dermatol. 1991;10(4):296-302. PubMed PMID: 1764357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Skin manifestations of biotin deficiency. A1 - Mock,D M, PY - 1991/12/1/pubmed PY - 1991/12/1/medline PY - 1991/12/1/entrez SP - 296 EP - 302 JF - Seminars in dermatology JO - Semin Dermatol VL - 10 IS - 4 N2 - This article reviews current knowledge concerning the dermatologic manifestations of biotin deficiency. Biotin is a water-soluble vitamin that acts as an essential cofactor for four carboxylases, each of which catalyzes an essential step in intermediary metabolism. For example, acetyl-CoA carboxylase catalyzes the rate-limiting step in fatty acid elongation. In infants, children, and adults, deficiency of biotin causes alopecia and a characteristic scaly, erythematous dermatitis distributed around body orifices. The rash closely resembles that of zinc deficiency. Candida albicans often can be cultured from the skin lesions. Biotinidase deficiency, an inborn error, causes biotin deficiency, probably as a consequence of unpaired intestinal absorption, cellular salvage, and renal reclamation of biotin; biotinidase deficiency causes dermatologic manifestations similar to biotin deficiency. There is evidence that impaired fatty acid metabolism secondary to reduced activities of the biotin-dependent carboxylases (especially acetyl-CoA carboxylase) plays an etiologic role in the dermatologic manifestations of biotin deficiency. Candida infections secondary to impaired immune function might also contribute to the dermatitis of biotin deficiency. SN - 0278-145X UR - https://www.unboundmedicine.com/medline/citation/1764357/Skin_manifestations_of_biotin_deficiency_ L2 - https://medlineplus.gov/skinconditions.html DB - PRIME DP - Unbound Medicine ER -