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Pre-exposure rabies vaccination using purified chick embryo cell rabies vaccine intradermally is immunogenic and safe.
J Pediatr. 2007 Aug; 151(2):173-7.JPed

Abstract

OBJECTIVE

To demonstrate the safety and immunogenicity of intradermal rabies pre-exposure prophylaxis with purified chick embryo cell vaccine (PCECV) in schoolchildren age 5 to 8 years in Thailand.

STUDY DESIGN

In a randomized, open-label, phase II clinical trial, 2 or 3 intradermal doses of 0.1 mL PCECV (Rabipur) were administered to 703 schoolchildren on days 0 and 28 or on days 0, 7, and 28. In 206 children, 2 simulated post-exposure booster doses were given 1 year after the primary vaccination series. Rabies virus- neutralizing antibody (RVNA) titers were determined by the rapid fluorescent focus inhibition test.

RESULTS

In school-age children in Thailand, a pre-exposure immunization regimen of 3 intradermal doses of PCECV produced adequate immune responses. After primary vaccination, all subjects developed RVNA titers > or =0.5 IU/mL and demonstrated a rapid increase in RVNA titer after 2 simulated post-exposure booster immunizations 1 year after the primary vaccination series. No serious adverse drug reactions occurred.

CONCLUSIONS

Rabies pre-exposure immunization with PCECV is safe and immunogenic, and its implementation could save the lives of many children in rabies-endemic areas.

Authors+Show Affiliations

Provincial Health Office of Phetchabun, Ministry of Health, Phetchabun, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial, Phase II
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17643772

Citation

Kamoltham, Thavatchai, et al. "Pre-exposure Rabies Vaccination Using Purified Chick Embryo Cell Rabies Vaccine Intradermally Is Immunogenic and Safe." The Journal of Pediatrics, vol. 151, no. 2, 2007, pp. 173-7.
Kamoltham T, Thinyounyong W, Phongchamnaphai P, et al. Pre-exposure rabies vaccination using purified chick embryo cell rabies vaccine intradermally is immunogenic and safe. J Pediatr. 2007;151(2):173-7.
Kamoltham, T., Thinyounyong, W., Phongchamnaphai, P., Phraisuwan, P., Khawplod, P., Banzhoff, A., & Malerczyk, C. (2007). Pre-exposure rabies vaccination using purified chick embryo cell rabies vaccine intradermally is immunogenic and safe. The Journal of Pediatrics, 151(2), 173-7.
Kamoltham T, et al. Pre-exposure Rabies Vaccination Using Purified Chick Embryo Cell Rabies Vaccine Intradermally Is Immunogenic and Safe. J Pediatr. 2007;151(2):173-7. PubMed PMID: 17643772.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pre-exposure rabies vaccination using purified chick embryo cell rabies vaccine intradermally is immunogenic and safe. AU - Kamoltham,Thavatchai, AU - Thinyounyong,Wirawan, AU - Phongchamnaphai,Phana, AU - Phraisuwan,Phran, AU - Khawplod,Pakamatz, AU - Banzhoff,Angelika, AU - Malerczyk,Claudius, PY - 2006/09/08/received PY - 2006/12/12/revised PY - 2007/02/15/accepted PY - 2007/7/24/pubmed PY - 2007/8/23/medline PY - 2007/7/24/entrez SP - 173 EP - 7 JF - The Journal of pediatrics JO - J Pediatr VL - 151 IS - 2 N2 - OBJECTIVE: To demonstrate the safety and immunogenicity of intradermal rabies pre-exposure prophylaxis with purified chick embryo cell vaccine (PCECV) in schoolchildren age 5 to 8 years in Thailand. STUDY DESIGN: In a randomized, open-label, phase II clinical trial, 2 or 3 intradermal doses of 0.1 mL PCECV (Rabipur) were administered to 703 schoolchildren on days 0 and 28 or on days 0, 7, and 28. In 206 children, 2 simulated post-exposure booster doses were given 1 year after the primary vaccination series. Rabies virus- neutralizing antibody (RVNA) titers were determined by the rapid fluorescent focus inhibition test. RESULTS: In school-age children in Thailand, a pre-exposure immunization regimen of 3 intradermal doses of PCECV produced adequate immune responses. After primary vaccination, all subjects developed RVNA titers > or =0.5 IU/mL and demonstrated a rapid increase in RVNA titer after 2 simulated post-exposure booster immunizations 1 year after the primary vaccination series. No serious adverse drug reactions occurred. CONCLUSIONS: Rabies pre-exposure immunization with PCECV is safe and immunogenic, and its implementation could save the lives of many children in rabies-endemic areas. SN - 1097-6833 UR - https://www.unboundmedicine.com/medline/citation/17643772/Pre_exposure_rabies_vaccination_using_purified_chick_embryo_cell_rabies_vaccine_intradermally_is_immunogenic_and_safe_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(07)00170-9 DB - PRIME DP - Unbound Medicine ER -