Abstract
OBJECTIVE
The purpose of this study was to evaluate the usefulness of sensory nerve conduction studies in comparison and in combination with motor conductions in diagnosing chronic inflammatory demyelinating polyneuropathy (CIDP).
METHODS
We retrospectively compared the electrophysiology of 20 patients with CIDP to that of 20 controls with axonal polyneuropathy, and 20 controls with myopathy. Five sensory abnormality patterns were evaluated.
RESULTS
The "abnormal radial normal sural" ("ARNS") pattern showed a sensitivity of 25% for CIDP and specificity of 100% versus axonal neuropathies (p=0.047). The "abnormal sural normal radial" ("ASNR") pattern had a sensitivity of 75% for axonal neuropathy with a specificity of 80% versus CIDP (p=0.0012). Presence of ARNS or absence of ASNR patterns showed equivalent or superior sensitivity and specificity to most individual motor demyelinating defects for CIDP. Presence of ARNS or absence of ASNR patterns, integrated within three different sets of electrodiagnostic criteria for CIDP, increased sensitivity in all without significantly altering specificity. Effects were most remarkable with the American Academy of Neurology criteria (1991), which showed significantly improved sensitivity (50-85%; p=0.041), with preserved specificity of 100%.
CONCLUSIONS
The use of sensory abnormality patterns appears justified in comparison and combination with motor defects in diagnosing CIDP.
SIGNIFICANCE
Sensory studies may be useful in contributing to the electrodiagnosis of CIDP and their inclusion in existing electrodiagnostic criteria deserves consideration.
TY - JOUR
T1 - The value of sensory electrophysiology in chronic inflammatory demyelinating polyneuropathy.
AU - Rajabally,Yusuf A,
AU - Narasimhan,Manisha,
Y1 - 2007/07/23/
PY - 2007/04/09/received
PY - 2007/05/13/revised
PY - 2007/06/10/accepted
PY - 2007/7/24/pubmed
PY - 2007/10/3/medline
PY - 2007/7/24/entrez
SP - 1999
EP - 2004
JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
JO - Clin Neurophysiol
VL - 118
IS - 9
N2 - OBJECTIVE: The purpose of this study was to evaluate the usefulness of sensory nerve conduction studies in comparison and in combination with motor conductions in diagnosing chronic inflammatory demyelinating polyneuropathy (CIDP). METHODS: We retrospectively compared the electrophysiology of 20 patients with CIDP to that of 20 controls with axonal polyneuropathy, and 20 controls with myopathy. Five sensory abnormality patterns were evaluated. RESULTS: The "abnormal radial normal sural" ("ARNS") pattern showed a sensitivity of 25% for CIDP and specificity of 100% versus axonal neuropathies (p=0.047). The "abnormal sural normal radial" ("ASNR") pattern had a sensitivity of 75% for axonal neuropathy with a specificity of 80% versus CIDP (p=0.0012). Presence of ARNS or absence of ASNR patterns showed equivalent or superior sensitivity and specificity to most individual motor demyelinating defects for CIDP. Presence of ARNS or absence of ASNR patterns, integrated within three different sets of electrodiagnostic criteria for CIDP, increased sensitivity in all without significantly altering specificity. Effects were most remarkable with the American Academy of Neurology criteria (1991), which showed significantly improved sensitivity (50-85%; p=0.041), with preserved specificity of 100%. CONCLUSIONS: The use of sensory abnormality patterns appears justified in comparison and combination with motor defects in diagnosing CIDP. SIGNIFICANCE: Sensory studies may be useful in contributing to the electrodiagnosis of CIDP and their inclusion in existing electrodiagnostic criteria deserves consideration.
SN - 1388-2457
UR - https://www.unboundmedicine.com/medline/citation/17644033/The_value_of_sensory_electrophysiology_in_chronic_inflammatory_demyelinating_polyneuropathy_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388-2457(07)00316-1
DB - PRIME
DP - Unbound Medicine
ER -
