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Examination of encapsulated phytosterol ester supplementation on lipid indices associated with cardiovascular disease.

Abstract

OBJECTIVE

As opposed to traditional food based delivery we examined the efficacy of ingesting encapsulated phytosterol esters on indices of lipid health in hypercholesterolemic adults.

METHODS

We performed a randomized, double-blinded, parallel-group, placebo-controlled, clinical intervention examining 54 men and women (20-70 y of age) with a low-density lipoprotein cholesterol (LDL-C) level > or =3.33 mmol/L. Participants were not taking cholesterol-lowering medications. Treatment consisted of ingesting 2.6 g of encapsulated phytosterol esters (n = 25) or a matching placebo (n = 29) for 12 wk.

RESULTS

Total cholesterol (TC) levels at baseline (mean +/- SD) were 6.29 +/- 0.7 mmol/L in the phytosterol group and 6.00 +/- 0.7 mmol/L in the placebo group. Baseline LDL-C levels were 4.27 +/- 0.7 mmol/L in the treatment group and 4.00 +/- 0.8 mmol/L in the placebo group. Analysis of variance and Tukey's least significant difference post hoc analyses revealed a significant within-group reduction in TC (-0.23 +/- 0.4 mmol/L, P < 0.05) and LDL-C (-0.22 +/- 0.5 mmol/L, P < 0.05) for the phytosterol treatment group. Mean reductions in TC and LDL-C were greater than placebo (P < 0.05). Percentages of change from baseline for TC were -3.52% (95% confidence interval -6.44 to -0.40) for phytosterol treatment and 2.64% (95% confidence interval 0.30-5.60) for placebo. Those for LDL-C were -5.00% (95% confidence interval -9.92 to -0.08) for phytosterol and 4.89 (95% confidence interval 0.24-9.5) for placebo. No other significant effects were observed.

CONCLUSION

Encapsulated phytosterol ester ingestion appears to positively modulate LDL-C. Given that the reduction in LDL-C was not as extensive as in food-based trials, future investigations should examine potential timing and dose issues relative to encapsulated delivery.

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  • Authors+Show Affiliations

    ,

    Pennington Biomedical Research Center, Preventive Medicine Laboratory, Baton Rouge, Louisiana, USA. conrad.earnest@pbrc.edu

    , , ,

    Source

    MeSH

    Adult
    Aged
    Analysis of Variance
    Anticholesteremic Agents
    Cardiovascular Diseases
    Cholesterol
    Cholesterol, HDL
    Cholesterol, LDL
    Dietary Supplements
    Double-Blind Method
    Female
    Humans
    Hypercholesterolemia
    Male
    Middle Aged
    Phytosterols

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    17644340

    Citation

    Earnest, Conrad P., et al. "Examination of Encapsulated Phytosterol Ester Supplementation On Lipid Indices Associated With Cardiovascular Disease." Nutrition (Burbank, Los Angeles County, Calif.), vol. 23, no. 9, 2007, pp. 625-33.
    Earnest CP, Mikus CR, Lemieux I, et al. Examination of encapsulated phytosterol ester supplementation on lipid indices associated with cardiovascular disease. Nutrition. 2007;23(9):625-33.
    Earnest, C. P., Mikus, C. R., Lemieux, I., Arsenault, B. J., & Church, T. S. (2007). Examination of encapsulated phytosterol ester supplementation on lipid indices associated with cardiovascular disease. Nutrition (Burbank, Los Angeles County, Calif.), 23(9), pp. 625-33.
    Earnest CP, et al. Examination of Encapsulated Phytosterol Ester Supplementation On Lipid Indices Associated With Cardiovascular Disease. Nutrition. 2007;23(9):625-33. PubMed PMID: 17644340.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Examination of encapsulated phytosterol ester supplementation on lipid indices associated with cardiovascular disease. AU - Earnest,Conrad P, AU - Mikus,Catherine R, AU - Lemieux,Isabelle, AU - Arsenault,Benoit J, AU - Church,Timothy S, Y1 - 2007/07/20/ PY - 2007/03/21/received PY - 2007/06/04/revised PY - 2007/06/05/accepted PY - 2007/7/24/pubmed PY - 2007/10/12/medline PY - 2007/7/24/entrez SP - 625 EP - 33 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 23 IS - 9 N2 - OBJECTIVE: As opposed to traditional food based delivery we examined the efficacy of ingesting encapsulated phytosterol esters on indices of lipid health in hypercholesterolemic adults. METHODS: We performed a randomized, double-blinded, parallel-group, placebo-controlled, clinical intervention examining 54 men and women (20-70 y of age) with a low-density lipoprotein cholesterol (LDL-C) level > or =3.33 mmol/L. Participants were not taking cholesterol-lowering medications. Treatment consisted of ingesting 2.6 g of encapsulated phytosterol esters (n = 25) or a matching placebo (n = 29) for 12 wk. RESULTS: Total cholesterol (TC) levels at baseline (mean +/- SD) were 6.29 +/- 0.7 mmol/L in the phytosterol group and 6.00 +/- 0.7 mmol/L in the placebo group. Baseline LDL-C levels were 4.27 +/- 0.7 mmol/L in the treatment group and 4.00 +/- 0.8 mmol/L in the placebo group. Analysis of variance and Tukey's least significant difference post hoc analyses revealed a significant within-group reduction in TC (-0.23 +/- 0.4 mmol/L, P < 0.05) and LDL-C (-0.22 +/- 0.5 mmol/L, P < 0.05) for the phytosterol treatment group. Mean reductions in TC and LDL-C were greater than placebo (P < 0.05). Percentages of change from baseline for TC were -3.52% (95% confidence interval -6.44 to -0.40) for phytosterol treatment and 2.64% (95% confidence interval 0.30-5.60) for placebo. Those for LDL-C were -5.00% (95% confidence interval -9.92 to -0.08) for phytosterol and 4.89 (95% confidence interval 0.24-9.5) for placebo. No other significant effects were observed. CONCLUSION: Encapsulated phytosterol ester ingestion appears to positively modulate LDL-C. Given that the reduction in LDL-C was not as extensive as in food-based trials, future investigations should examine potential timing and dose issues relative to encapsulated delivery. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/17644340/Examination_of_encapsulated_phytosterol_ester_supplementation_on_lipid_indices_associated_with_cardiovascular_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(07)00180-3 DB - PRIME DP - Unbound Medicine ER -