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Impact of restless legs syndrome and iron deficiency on attention-deficit/hyperactivity disorder in children.
Sleep Med 2007; 8(7-8):711-5SM

Abstract

OBJECTIVE

Increasing evidence suggests a significant comorbidity between attention-deficit/hyperactivity disorder (ADHD) and restless legs syndrome (RLS). Iron deficiency may underlie common pathophysiological mechanisms in subjects with ADHD plus RLS (ADHD+RLS). To date, the impact of iron deficiency, RLS and familial history of RLS on ADHD severity has been scarcely examined in children. These issues are addressed in the present study.

METHODS

Serum ferritin levels, familial history of RLS (diagnosed using National Institutes of Health (NIH) criteria) and previous iron supplementation in infancy were assessed in 12 ADHD+RLS children, 10 ADHD children and 10 controls. RLS was diagnosed using NIH-specific pediatric criteria, and ADHD severity was assessed using the Conners' Parent Rating scale.

RESULTS

ADHD symptom severity was higher, although not significantly, in children with ADHD+RLS compared to ADHD. The mean serum ferritin levels were significantly lower in children with ADHD than in the control group (p<0.0005). There was a trend for lower ferritin levels in ADHD+RLS subjects versus ADHD. Both a positive family history of RLS and previous iron supplementation in infancy were associated with more severe ADHD scores.

CONCLUSIONS

Children with ADHD and a positive family history of RLS appear to represent a subgroup particularly at risk for severe ADHD symptoms. Iron deficiency may contribute to the severity of symptoms. We suggest that clinicians consider assessing children with ADHD for RLS, a family history of RLS, and iron deficiency.

Authors+Show Affiliations

Service de Psychopathologie de l'Enfant et de l'Adolescent, Hôpital Robert Debré, 48 boulevard Sérurier, 75019 Paris, France. eric.konofal@rdb.aphp.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17644481

Citation

Konofal, Eric, et al. "Impact of Restless Legs Syndrome and Iron Deficiency On Attention-deficit/hyperactivity Disorder in Children." Sleep Medicine, vol. 8, no. 7-8, 2007, pp. 711-5.
Konofal E, Cortese S, Marchand M, et al. Impact of restless legs syndrome and iron deficiency on attention-deficit/hyperactivity disorder in children. Sleep Med. 2007;8(7-8):711-5.
Konofal, E., Cortese, S., Marchand, M., Mouren, M. C., Arnulf, I., & Lecendreux, M. (2007). Impact of restless legs syndrome and iron deficiency on attention-deficit/hyperactivity disorder in children. Sleep Medicine, 8(7-8), pp. 711-5.
Konofal E, et al. Impact of Restless Legs Syndrome and Iron Deficiency On Attention-deficit/hyperactivity Disorder in Children. Sleep Med. 2007;8(7-8):711-5. PubMed PMID: 17644481.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of restless legs syndrome and iron deficiency on attention-deficit/hyperactivity disorder in children. AU - Konofal,Eric, AU - Cortese,Samuele, AU - Marchand,Martine, AU - Mouren,Marie-Christine, AU - Arnulf,Isabelle, AU - Lecendreux,Michel, Y1 - 2007/07/20/ PY - 2007/02/25/received PY - 2007/04/10/revised PY - 2007/04/24/accepted PY - 2007/7/24/pubmed PY - 2008/2/5/medline PY - 2007/7/24/entrez SP - 711 EP - 5 JF - Sleep medicine JO - Sleep Med. VL - 8 IS - 7-8 N2 - OBJECTIVE: Increasing evidence suggests a significant comorbidity between attention-deficit/hyperactivity disorder (ADHD) and restless legs syndrome (RLS). Iron deficiency may underlie common pathophysiological mechanisms in subjects with ADHD plus RLS (ADHD+RLS). To date, the impact of iron deficiency, RLS and familial history of RLS on ADHD severity has been scarcely examined in children. These issues are addressed in the present study. METHODS: Serum ferritin levels, familial history of RLS (diagnosed using National Institutes of Health (NIH) criteria) and previous iron supplementation in infancy were assessed in 12 ADHD+RLS children, 10 ADHD children and 10 controls. RLS was diagnosed using NIH-specific pediatric criteria, and ADHD severity was assessed using the Conners' Parent Rating scale. RESULTS: ADHD symptom severity was higher, although not significantly, in children with ADHD+RLS compared to ADHD. The mean serum ferritin levels were significantly lower in children with ADHD than in the control group (p<0.0005). There was a trend for lower ferritin levels in ADHD+RLS subjects versus ADHD. Both a positive family history of RLS and previous iron supplementation in infancy were associated with more severe ADHD scores. CONCLUSIONS: Children with ADHD and a positive family history of RLS appear to represent a subgroup particularly at risk for severe ADHD symptoms. Iron deficiency may contribute to the severity of symptoms. We suggest that clinicians consider assessing children with ADHD for RLS, a family history of RLS, and iron deficiency. SN - 1389-9457 UR - https://www.unboundmedicine.com/medline/citation/17644481/Impact_of_restless_legs_syndrome_and_iron_deficiency_on_attention_deficit/hyperactivity_disorder_in_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1389-9457(07)00187-6 DB - PRIME DP - Unbound Medicine ER -