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Association of serum uric acid with cardiovascular disease in rheumatoid arthritis.
Rheumatology (Oxford). 2007 Sep; 46(9):1466-70.R

Abstract

OBJECTIVES

Elevated serum uric acid (SUA) levels have been associated with cardiovascular disease (CVD) in the general population. Rheumatoid arthritis (RA) is not thought to associate with high SUA but is characterized by increased CVD morbidity and mortality. We aimed to explore a potential association of SUA with CVD in RA patients and to evaluate whether such an association is present when the traditional CVD risk factors are taken into account.

METHODS

. 400 consecutive RA patients were recruited in this cross-sectional study and had all traditional CVD risk factors and SUA assessed. The association of SUA levels with other variables was assessed using bivariate correlations. Subsequent binary logistic models with appropriate adjustments were used to test the independence of the association between SUA and CVD.

RESULTS

SUA levels were significantly higher in RA patients with CVD (RA + CVD) compared with RA patients without CVD (RA - CVD) (5.68 +/- 1.81 mg dl(-1) vs 5.06 +/- 1.41 mg dl(-1), P = 0.001). After adjusting for CVD risk factors, physical function (health assessment questionnaire, HAQ) and use of diuretics and/or statins the association between SUA and CVD in RA patients remained significant [Odds ratio (OR) = 1.36, 95% confidence interval (CI) 1.04-1.79, P = 0.025]. Compared with subjects with SUA levels in the lowest quintile (<3.86 mg dl(-1)), those within the highest quintile (>/=6.38 mg dl(-1)) had a 6-fold increase in the odds of having CVD (adjusted OR 6.46, 95% CI 1.66-25.05, P = 0.007).

CONCLUSIONS

This cross-sectional study suggests that SUA may be independently associated with CVD in RA patients. This needs to be confirmed in prospective studies.

Authors+Show Affiliations

Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Pensnett Road, Dudley, West Midlands, DY1 2HQ, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17644822

Citation

Panoulas, V F., et al. "Association of Serum Uric Acid With Cardiovascular Disease in Rheumatoid Arthritis." Rheumatology (Oxford, England), vol. 46, no. 9, 2007, pp. 1466-70.
Panoulas VF, Milionis HJ, Douglas KM, et al. Association of serum uric acid with cardiovascular disease in rheumatoid arthritis. Rheumatology (Oxford). 2007;46(9):1466-70.
Panoulas, V. F., Milionis, H. J., Douglas, K. M., Nightingale, P., Kita, M. D., Klocke, R., Elisaf, M. S., & Kitas, G. D. (2007). Association of serum uric acid with cardiovascular disease in rheumatoid arthritis. Rheumatology (Oxford, England), 46(9), 1466-70.
Panoulas VF, et al. Association of Serum Uric Acid With Cardiovascular Disease in Rheumatoid Arthritis. Rheumatology (Oxford). 2007;46(9):1466-70. PubMed PMID: 17644822.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of serum uric acid with cardiovascular disease in rheumatoid arthritis. AU - Panoulas,V F, AU - Milionis,H J, AU - Douglas,K M J, AU - Nightingale,P, AU - Kita,M D, AU - Klocke,R, AU - Elisaf,M S, AU - Kitas,G D, Y1 - 2007/07/21/ PY - 2007/7/24/pubmed PY - 2007/10/25/medline PY - 2007/7/24/entrez SP - 1466 EP - 70 JF - Rheumatology (Oxford, England) JO - Rheumatology (Oxford) VL - 46 IS - 9 N2 - OBJECTIVES: Elevated serum uric acid (SUA) levels have been associated with cardiovascular disease (CVD) in the general population. Rheumatoid arthritis (RA) is not thought to associate with high SUA but is characterized by increased CVD morbidity and mortality. We aimed to explore a potential association of SUA with CVD in RA patients and to evaluate whether such an association is present when the traditional CVD risk factors are taken into account. METHODS: . 400 consecutive RA patients were recruited in this cross-sectional study and had all traditional CVD risk factors and SUA assessed. The association of SUA levels with other variables was assessed using bivariate correlations. Subsequent binary logistic models with appropriate adjustments were used to test the independence of the association between SUA and CVD. RESULTS: SUA levels were significantly higher in RA patients with CVD (RA + CVD) compared with RA patients without CVD (RA - CVD) (5.68 +/- 1.81 mg dl(-1) vs 5.06 +/- 1.41 mg dl(-1), P = 0.001). After adjusting for CVD risk factors, physical function (health assessment questionnaire, HAQ) and use of diuretics and/or statins the association between SUA and CVD in RA patients remained significant [Odds ratio (OR) = 1.36, 95% confidence interval (CI) 1.04-1.79, P = 0.025]. Compared with subjects with SUA levels in the lowest quintile (<3.86 mg dl(-1)), those within the highest quintile (>/=6.38 mg dl(-1)) had a 6-fold increase in the odds of having CVD (adjusted OR 6.46, 95% CI 1.66-25.05, P = 0.007). CONCLUSIONS: This cross-sectional study suggests that SUA may be independently associated with CVD in RA patients. This needs to be confirmed in prospective studies. SN - 1462-0324 UR - https://www.unboundmedicine.com/medline/citation/17644822/Association_of_serum_uric_acid_with_cardiovascular_disease_in_rheumatoid_arthritis_ L2 - https://academic.oup.com/rheumatology/article-lookup/doi/10.1093/rheumatology/kem159 DB - PRIME DP - Unbound Medicine ER -