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Osteoporosis: prevention and treatment in anorexia nervosa.
Eat Weight Disord 2002; 7(2):72-81EW

Abstract

One of the most serious and potentially permanently disabling medical complications of anorexia nervosa is osteoporosis, which greatly increases the long-term risk of bone fractures. The decreased bone density in patients with anorexia nervosa (AN) is due to the many effects on bone metabolism of amenorrhea, reduced levels of insulin growth factor-1 (IGF-1), high cortisol levels and weight loss. Although estrogen replacement therapy is clearly efficacious in preventing postmenopausal osteoporosis, its efficacy in AN is uncertain. Clinicians caring for patients with AN need to be aware of this because, despite such therapy, there may be an inexorable decline in bone mineral density in what is a relatively young group of patients. AN frequently has its onset during adolescence, when peak bone mass is normally reached, and an anorectic episode in youth may permanently impair skeletal integrity and lead to debilitating fractures and pain. It is important to recognise this formidable risk, counsel AN patients about the longterm and possibly permanent sequelae of low body weight, use densitometry to screen for bone loss and treat it accordingly. The most effective treatment is still early weight restoration and the resumption of menses.

Authors+Show Affiliations

Division of Internal Medicine, Denver Health, Denver, CO, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17644861

Citation

Wolfert, A, and P S. Mehler. "Osteoporosis: Prevention and Treatment in Anorexia Nervosa." Eating and Weight Disorders : EWD, vol. 7, no. 2, 2002, pp. 72-81.
Wolfert A, Mehler PS. Osteoporosis: prevention and treatment in anorexia nervosa. Eat Weight Disord. 2002;7(2):72-81.
Wolfert, A., & Mehler, P. S. (2002). Osteoporosis: prevention and treatment in anorexia nervosa. Eating and Weight Disorders : EWD, 7(2), pp. 72-81.
Wolfert A, Mehler PS. Osteoporosis: Prevention and Treatment in Anorexia Nervosa. Eat Weight Disord. 2002;7(2):72-81. PubMed PMID: 17644861.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Osteoporosis: prevention and treatment in anorexia nervosa. AU - Wolfert,A, AU - Mehler,P S, PY - 2007/7/25/pubmed PY - 2007/8/19/medline PY - 2007/7/25/entrez SP - 72 EP - 81 JF - Eating and weight disorders : EWD JO - Eat Weight Disord VL - 7 IS - 2 N2 - One of the most serious and potentially permanently disabling medical complications of anorexia nervosa is osteoporosis, which greatly increases the long-term risk of bone fractures. The decreased bone density in patients with anorexia nervosa (AN) is due to the many effects on bone metabolism of amenorrhea, reduced levels of insulin growth factor-1 (IGF-1), high cortisol levels and weight loss. Although estrogen replacement therapy is clearly efficacious in preventing postmenopausal osteoporosis, its efficacy in AN is uncertain. Clinicians caring for patients with AN need to be aware of this because, despite such therapy, there may be an inexorable decline in bone mineral density in what is a relatively young group of patients. AN frequently has its onset during adolescence, when peak bone mass is normally reached, and an anorectic episode in youth may permanently impair skeletal integrity and lead to debilitating fractures and pain. It is important to recognise this formidable risk, counsel AN patients about the longterm and possibly permanent sequelae of low body weight, use densitometry to screen for bone loss and treat it accordingly. The most effective treatment is still early weight restoration and the resumption of menses. SN - 1124-4909 UR - https://www.unboundmedicine.com/medline/citation/17644861/Osteoporosis:_prevention_and_treatment_in_anorexia_nervosa_ L2 - http://www.diseaseinfosearch.org/result/9059 DB - PRIME DP - Unbound Medicine ER -