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Electroencephalographic sleep profiles and hypothalamic-pituitary-adrenocortical (HPA)-activity in kindergarten children: early indication of poor sleep quality associated with increased cortisol secretion.
J Psychiatr Res. 2008 Jun; 42(7):532-43.JP

Abstract

OBJECTIVES

In children, objective data carried out from sleep EEG monitoring are scarce. Furthermore, results associating the hypothalamic-pituitary-adrenocortical (HPA)-activity with sleep EEG measurements in children are missing. Therefore, our study aimed to investigate in preschool-children the association between sleep patterns and endocrine activity. Furthermore, children's behavioral/emotional difficulties and competences were assessed in order to correlate psychological strain with sleep measures.

PARTICIPANTS AND METHODS

Sixty-seven kindergarten children (35 boys and 32 girls) aged 5.34 underwent EEG-monitoring for one night. For baseline HPA-activity assessment, saliva samples were collected immediately after awakening, whereas saliva samples before, while and after a psychological challenge were used to assess the HPA-activity under stress conditions.

RESULTS

Compared to girls, boys showed significantly more REM sleep time. After cluster analysis, children labeled as 'poor' sleepers (n=27; 40,30%) showed significantly increased morning cortisol values, as compared to 'good' sleepers (n=22; 32,83%). Furthermore, increased cortisol AUC values under stress conditions were significantly associated with an elevated number of awakenings after sleep onset, and more sleep time in stages 1 and 2. In addition, an increased sleep efficiency was significantly correlated with self-reported emotional/behavioral difficulties, i.e. with low degrees of impulsivity (r=-.31; p<.05) and lower degrees of social inhibition and peer victimiziation (r=-.26, p<.05).

CONCLUSIONS

Our results underlined that already in preschool years, associations between objectively examined unfavorable sleep patterns, increased HPA-system activity and more difficult behavioral and psychosocial dimensions may be observed.

Authors+Show Affiliations

Psychiatric Out-Patient Department, University Hospital Basel, Switzerland. christine.haselbach@upkbs.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17645894

Citation

Hatzinger, Martin, et al. "Electroencephalographic Sleep Profiles and Hypothalamic-pituitary-adrenocortical (HPA)-activity in Kindergarten Children: Early Indication of Poor Sleep Quality Associated With Increased Cortisol Secretion." Journal of Psychiatric Research, vol. 42, no. 7, 2008, pp. 532-43.
Hatzinger M, Brand S, Perren S, et al. Electroencephalographic sleep profiles and hypothalamic-pituitary-adrenocortical (HPA)-activity in kindergarten children: early indication of poor sleep quality associated with increased cortisol secretion. J Psychiatr Res. 2008;42(7):532-43.
Hatzinger, M., Brand, S., Perren, S., Stadelmann, S., von Wyl, A., von Klitzing, K., & Holsboer-Trachsler, E. (2008). Electroencephalographic sleep profiles and hypothalamic-pituitary-adrenocortical (HPA)-activity in kindergarten children: early indication of poor sleep quality associated with increased cortisol secretion. Journal of Psychiatric Research, 42(7), 532-43.
Hatzinger M, et al. Electroencephalographic Sleep Profiles and Hypothalamic-pituitary-adrenocortical (HPA)-activity in Kindergarten Children: Early Indication of Poor Sleep Quality Associated With Increased Cortisol Secretion. J Psychiatr Res. 2008;42(7):532-43. PubMed PMID: 17645894.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electroencephalographic sleep profiles and hypothalamic-pituitary-adrenocortical (HPA)-activity in kindergarten children: early indication of poor sleep quality associated with increased cortisol secretion. AU - Hatzinger,Martin, AU - Brand,Serge, AU - Perren,Sonja, AU - Stadelmann,Stephanie, AU - von Wyl,Agnes, AU - von Klitzing,Kai, AU - Holsboer-Trachsler,Edith, Y1 - 2007/07/23/ PY - 2007/03/23/received PY - 2007/05/15/revised PY - 2007/05/22/accepted PY - 2007/7/25/pubmed PY - 2008/8/8/medline PY - 2007/7/25/entrez SP - 532 EP - 43 JF - Journal of psychiatric research JO - J Psychiatr Res VL - 42 IS - 7 N2 - OBJECTIVES: In children, objective data carried out from sleep EEG monitoring are scarce. Furthermore, results associating the hypothalamic-pituitary-adrenocortical (HPA)-activity with sleep EEG measurements in children are missing. Therefore, our study aimed to investigate in preschool-children the association between sleep patterns and endocrine activity. Furthermore, children's behavioral/emotional difficulties and competences were assessed in order to correlate psychological strain with sleep measures. PARTICIPANTS AND METHODS: Sixty-seven kindergarten children (35 boys and 32 girls) aged 5.34 underwent EEG-monitoring for one night. For baseline HPA-activity assessment, saliva samples were collected immediately after awakening, whereas saliva samples before, while and after a psychological challenge were used to assess the HPA-activity under stress conditions. RESULTS: Compared to girls, boys showed significantly more REM sleep time. After cluster analysis, children labeled as 'poor' sleepers (n=27; 40,30%) showed significantly increased morning cortisol values, as compared to 'good' sleepers (n=22; 32,83%). Furthermore, increased cortisol AUC values under stress conditions were significantly associated with an elevated number of awakenings after sleep onset, and more sleep time in stages 1 and 2. In addition, an increased sleep efficiency was significantly correlated with self-reported emotional/behavioral difficulties, i.e. with low degrees of impulsivity (r=-.31; p<.05) and lower degrees of social inhibition and peer victimiziation (r=-.26, p<.05). CONCLUSIONS: Our results underlined that already in preschool years, associations between objectively examined unfavorable sleep patterns, increased HPA-system activity and more difficult behavioral and psychosocial dimensions may be observed. SN - 0022-3956 UR - https://www.unboundmedicine.com/medline/citation/17645894/Electroencephalographic_sleep_profiles_and_hypothalamic_pituitary_adrenocortical__HPA__activity_in_kindergarten_children:_early_indication_of_poor_sleep_quality_associated_with_increased_cortisol_secretion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3956(07)00095-7 DB - PRIME DP - Unbound Medicine ER -